Profile Response Detail

Molecular Profile BRAF V600E
Therapy RAF265
Indication/Tumor Type Advanced Solid Tumor
Response Type sensitive
Create By c-seddy
Update By c-seddy

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E Advanced Solid Tumor sensitive RAF265 Preclinical Actionable In a preclinical study, RAF265 inhibited Erk phosphorylation and cell proliferation in BRAF V600E expressing cells in culture (PMID: 20538618). 20538618
PubMed Id Reference Title Details
(20538618) Gatekeeper mutations mediate resistance to BRAF-targeted therapies. Full reference...