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Ref Type
Authors Brad S Kahl, Mehdi Hamadani, Paolo Caimi, Carmelo Carlo-Stella, Erin Reid, Jay Feingold, Kirit M Ardeshna, John Radford, Melhem M Solh, Ki-Young Chung, Leonard Heffner, Shui He, Joseph Boni and Owen Anthony O'Connor
Title Encouraging Early Results from the First in-Human Clinical Trial of ADCT-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Based Antibody Drug Conjugate, in Relapsed/Refractory B-Cell Lineage Non-Hodgkin Lymphoma
Journal Blood
Abstract Text Blood 2017 130(Suppl 1):187


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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Drug Name Trade Name Synonyms Drug Classes Drug Description
Loncastuximab tesirine Lonca ADCT-402 CD19 Antibody 10 Loncastuximab tesirine (ADCT-402) is a human anti-CD19 antibody in conjugation with a pyrrolobenzodiazepine (PBD) dimer toxin, which may specifically target CD19-positive tumor cells (Blood 2017 130(Suppl 1):187, PMID: 32012214).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown diffuse large B-cell lymphoma not applicable Loncastuximab tesirine Phase I Actionable In a Phase I trial, Loncastuximab tesirine treatment resulted in an objective response rate of 57.1% (20/35) with a complete response rate of 34.3% (12/35) in patients with diffuse large B-cell lymphoma (Blood 2017 130(Suppl 1):187, NCT02669017). detail...