Reference Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Ref Type Journal Article
PMID (17124058)
Authors Small D
Title FLT3 mutations: biology and treatment.
Journal Hematology / the Education Program of the American Society of Hematology.
Vol
Issue
Date 2006
URL
Abstract Text FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is mutated in about 1/3 of acute myeloid leukemia (AML) patients, either by internal tandem duplications (ITD) of the juxtamembrane domain or by point mutations usually involving the kinase domain (KD). Both types of mutation constitutively activate FLT3. Many studies have shown that AML patients with FLT3/ITD mutations have poor cure rates due to relapse. This has led to the development of a number of small molecule tyrosine kinase inhibitors (TKI) with activity against FLT3. Many of these are still in preclinical development, but several have entered clinical phase I and II trials as monotherapy in patients with relapsed AML. Patients with FLT3 mutations in these trials have shown clinical responses, most often a clearing of peripheral blasts, but rarely major reductions of bone marrow blasts. Several studies have shown that FLT3 was successfully inhibited in most patients. However, complete remissions have rarely been achieved in these trials. The difference in responses of chronic myeloid leukemia (CML) patients to BCR-ABL inhibitors compared to FLT3 mutant AML patients to FLT3 inhibitors may be reflective of treating a single gene disease in CML versus multiply altered gene disease in AML. This has led to clinical testing of FLT3 TKI in combination with conventional chemotherapy, with trial designs based on preclinical testing showing synergistic effects between these agents in inducing cytotoxic responses. Several combination trials are ongoing or planned in both relapsed and newly diagnosed FLT3-mutant AML patients.

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Treatment Approach
FLT3 Y599_D600insSTDNEYFYVDFREYEY FLT3 Inhibitor
FLT3 V592A FLT3 Inhibitor
FLT3 V592G FLT3 Inhibitor
FLT3 act mut FLT3 Inhibitor
FLT3 F594_D600dup FLT3 Inhibitor
FLT3 Y599_D600insPAPQIMSTSTLISENMNIA FLT3 Inhibitor
FLT3 N841I FLT3 Inhibitor
FLT3 D835A FLT3 Inhibitor
FLT3 A680V FLT3 Inhibitor
FLT3 D835G FLT3 Inhibitor
FLT3 Y842C FLT3 Inhibitor
FLT3 W603_E604insDREYEYDLKW FLT3 Inhibitor
FLT3 D835N FLT3 Inhibitor
FLT3 D835V FLT3 Inhibitor
FLT3 amp FLT3 Inhibitor
FLT3 D835del FLT3 Inhibitor
FLT3 S451F FLT3 Inhibitor
FLT3 S585_F594dup FLT3 Inhibitor
FLT3 N676K FLT3 Inhibitor
FLT3 F594C FLT3 Inhibitor
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE FLT3 Inhibitor
FLT3 D835Y FLT3 Inhibitor
FLT3 I836del FLT3 Inhibitor
FLT3 R834Q FLT3 Inhibitor
FLT3 D593_D600dup FLT3 Inhibitor
FLT3 E598_Y599insDVDFREYE FLT3 Inhibitor
FLT3 over exp FLT3 Inhibitor
FLT3 V579A FLT3 Inhibitor
FLT3 Y599_D600insGLYVDFREYEY FLT3 Inhibitor
FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLEF FLT3 Inhibitor
FLT3 Y842H FLT3 Inhibitor
FLT3 L576R FLT3 Inhibitor
FLT3 D835H FLT3 Inhibitor
FLT3 D835E FLT3 Inhibitor
FLT3 F594L FLT3 Inhibitor
FLT3 D839G FLT3 Inhibitor
FLT3 Y599_D600insEYEYEYEY FLT3 Inhibitor
FLT3 F594Y FLT3 Inhibitor
FLT3 S840_N841insGS FLT3 Inhibitor
FLT3 I867S FLT3 Inhibitor
FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL FLT3 Inhibitor
FLT3 D835X FLT3 Inhibitor
FLT3 F590_F605dup FLT3 Inhibitor
FLT3 exon 14 ins FLT3 Inhibitor
FLT3 Y572C FLT3 Inhibitor
FLT3 R595_L601dup FLT3 Inhibitor
FLT3 Y597_K602dup FLT3 Inhibitor
FLT3 F590_Y591delinsGD FLT3 Inhibitor
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References