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Therapy Name | Cetuximab + Effi-DEM + Ezabenlimab |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Cetuximab | Erbitux | IMC-C225 | EGFR Antibody 58 | Erbitux (cetuximab) is a monoclonal antibody directed against EGFR, which inhibits signal transduction and cell proliferation (PMID: 28695301). Erbitux (cetuximab) is FDA approved for use in head and neck squamous cell carcinoma and KRAS wild-type, EGFR positive colorectal cancer (FDA.gov). |
Effi-DEM | OSE-172|BI 765063|BI-765063|OSE 172|BI765063 | Immune Checkpoint Inhibitor 148 | Effi-DEM (OSE-172) is a monoclonal antibody to the SIRPa receptor that blocks the CD47-SIRPa interaction to promote macrophage phagocytosis of tumor cells and may stimulate cytotoxic T-cells (PMID: 29873856). | |
Ezabenlimab | BI754091|BI-754091|BI 754091 | Immune Checkpoint Inhibitor 148 PD-L1/PD-1 antibody 119 | Ezabenlimab (BI 754091) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (J Clin Oncol. 36, no. 5_suppl (February 2018) 212-212). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05249426 | Phase I | Cetuximab + Effi-DEM + Ezabenlimab BI 836880 + Effi-DEM + Ezabenlimab Effi-DEM + Ezabenlimab | A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer | Active, not recruiting | USA | GBR | FRA | ESP | 7 |