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|Therapy Name||BGB-A425 + LBL-007 + Tislelizumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|BGB-A425||BGBA425|BGB A425||BGB-A425 is an antibody that targets Tim-3, potentially resulting in enhanced anti-tumor immune response and decreased tumor growth (Cancer Res July 1 2017 (77) (13 Supplement) 2628).|
|LBL-007||LBL007|LBL 007||LAG3 Antibody 18||LBL-007 targets LAG3 and prevents its interaction with MHC II molecules and liver sinusoidal endothelial cell lectin, potentially leading to relief of LAG-3 mediated immunosuppression and decreased tumor growth (PMID: 31242068).|
|Tislelizumab||BGB-A317||Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 112||Tislelizumab (BGB-A317) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05909904||Phase II||LBL-007 + Tislelizumab Tislelizumab BGB-A425 + Tislelizumab BGB-A425 + LBL-007 + Tislelizumab||Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma||Recruiting||USA | AUS||4|