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Therapy Name thioureidobutyronitrile
Synonyms
Therapy Description

Kevetrin (thioureidobutyronitrile) leads to stabilization of wild-type p53 and degradation of mutant p53, resulting in apoptosis and decreased growth of tumors with wild-type and mutant p53 (J Clin Oncol 31, 2013 (suppl; abstr TPS2627)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
thioureidobutyronitrile Kevetrin|NSC-525990 p53 Activator 11 Kevetrin (thioureidobutyronitrile) leads to stabilization of wild-type Tp53 and degradation of mutant Tp53, resulting in apoptosis and decreased growth of tumors with wild-type and mutant Tp53 (J Clin Oncol 31, 2013 (suppl; abstr TPS2627)).

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 del ovarian clear cell carcinoma predicted - sensitive thioureidobutyronitrile Preclinical - Cell line xenograft Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in Tp53-independent increase of Cdkn1a expression and apoptosis of ovarian clear cell carcinoma cells harboring TP53 deletion in culture and in cell line xenograft models (Proceedings of the AACR, Vol 58, Apr 2017, abstract # 3221). detail...
TP53 R248Q acute myeloid leukemia predicted - sensitive thioureidobutyronitrile Preclinical - Cell culture Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in apoptosis, decreased cell viability, elevated expression of Tp53 target genes, and increased Tp53 nuclear localization in an acute myeloid leukemia cell line harboring TP53 R248Q in culture (PMID: 32945487). 32945487
TP53 C242fs acute myeloid leukemia predicted - sensitive thioureidobutyronitrile Preclinical - Cell culture Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in apoptosis, decreased cell viability, altered cell cycle progression, elevated expression of Tp53 target genes, and increased Tp53 nuclear localization in an acute myeloid leukemia cell line harboring TP53 C242fs in culture (PMID: 32945487). 32945487
TP53 I255N acute myeloid leukemia predicted - sensitive thioureidobutyronitrile Preclinical - Patient cell culture Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment resulted in apoptosis of leukemic blast cells and decreased cell viability in patient-derived acute myeloid leukemia cells harboring TP53 I255N in culture (PMID: 32945487). 32945487
TP53 wild-type endometrioid ovary carcinoma sensitive thioureidobutyronitrile Preclinical - Cell line xenograft Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment increased Tp53 and Cdkn1a protein levels, resulted in growth inhibition of TP53 wild-type endometrioid ovary carcinoma cells in culture and in cell line xenograft models (Proceedings of the AACR, Vol 58, Apr 2017, abstract # 3221). detail...
TP53 mutant ovarian serous carcinoma sensitive thioureidobutyronitrile Preclinical - Cell culture Actionable In a preclinical study, Kevetrin (thioureidobutyronitrile) treatment decreased mutant Tp53 level, resulted in apoptosis of ovarian serous carcinoma cells harboring TP53 mutations in culture (Proceedings of the AACR, Vol 58, Apr 2017, abstract # 3221). detail...

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01664000 Phase I thioureidobutyronitrile A Safety, Pharmacokinetic and Pharmacodynamic Study of Kevetrin in Patients With Advanced Solid Tumors Completed USA 0
NCT03042702 Phase II thioureidobutyronitrile A Phase 2 Study of Kevetrin in Subjects With Ovarian Cancer Completed USA 0


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