Therapy Detail

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Therapy Name Cisplatin + Fluorouracil + Tislelizumab
Synonyms
Therapy Description

Tislelizumab (BGB-A317) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cisplatin Platinol CDDP Chemotherapy - Platinum 6 Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Fluorouracil Adrucil 5-FU Chemotherapy - Antimetabolite 12 Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov).
Tislelizumab BGB-A317 Immune Checkpoint Inhibitor 98 PD-L1/PD-1 antibody 68 Tislelizumab (BGB-A317) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown esophagus squamous cell carcinoma not applicable Cisplatin + Fluorouracil + Tislelizumab Phase II Actionable In a Phase II trial, Tislelizumab (BGB-A317) in combination with Platinol (cisplatin) and Adrucil (fluorouracil) demonstrated tolerability in patients with advanced esophageal squamous cell carcinoma and resulted in an objective response rate of 46.7% (7/15, all partial responses), disease control rate of 80% (12/15), median time to response of 10.0 weeks, and median progression-free survival of 10.4 months (PMID: 32561664; NCT03469557). 32561664

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03777657 Phase III Capecitabine + Oxaliplatin Cisplatin + Fluorouracil Capecitabine + Oxaliplatin + Tislelizumab Cisplatin + Fluorouracil + Tislelizumab Tislelizumab in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Gastric, or Gastroesophageal Junction Carcinoma Recruiting USA 13


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