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|Therapy Name||Paclitaxel + Y27632|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Paclitaxel||Taxol||7-Epipaclitaxel||Antimicrotubule Agent 12 BCL2 Family Inhibitor 6||Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).|
|Y27632||Y27632 is an inhibitor of Rho-associated protein kinase (ROCK1), which may block cellular adhesion, and lead to inhibition of colony formation and enhancement of cell detachment when combined with chemotherapeutic agents (PMID: 31160603, PMID: 23392171).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|