Disease Detail


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ID DOID:80630
Name B-lymphoblastic leukemia/lymphoma
Definition A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow.
Source DiseaseOntology.org
Alt Ids DOID:7061
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia lymphoid leukemia acute leukemia acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia B-lymphoblastic leukemia/lymphoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
NRAS G12D Anti-CD19 CAR-T cells B-lymphoblastic leukemia/lymphoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02328014 Phase Ib/II ACP-319 Acalabrutinib ACP-196 in Combination With ACP-319, for Treatment of B-Cell Malignancies Active, not recruiting USA 0
NCT02883049 Phase III Dasatinib Dexamethasone + Doxorubicin Prednisone Vincristine Sulfate Thioguanine Cytarabine Mercaptopurine Leucovorin Methotrexate Pegaspargase Etoposide Clofarabine Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Active, not recruiting USA | NZL | CAN | AUS 3
NCT02981628 Phase II Inotuzumab ozogamicin Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia Recruiting USA 1
NCT04690595 Phase I BAFFR-CAR T cells BAFFR Targeting CAR-T Cells for the Treatment of Relapsed or Refractory B-cell ALL Recruiting USA 0
NCT05327894 Phase III Blinatumomab Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia (Interfant-21) Recruiting NLD | ITA | FRA | DEU | BEL | AUT | AUS 11
NCT05674175 Phase Ib/II CART22-65s cells + huCART19 Co-administration of CART22-65s and huCART19 for B-ALL Recruiting USA 0