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ID DOID:80854
Name anaplastic pleomorphic xanthoastrocytoma
Definition A malignant astrocytoma that is characterized by the presence of five or more mitoses per 10 high-power fields.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer cell type cancer high grade glioma malignant astrocytoma anaplastic pleomorphic xanthoastrocytoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
BRAF V600E Dabrafenib + Trametinib anaplastic pleomorphic xanthoastrocytoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05429502 Phase Ib/II Ribociclib + Temozolomide + Topotecan Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors Recruiting USA | ITA | FRA | ESP | DEU | AUS 1
NCT05503797 Phase II Cobicistat + PLX8394 PLX8394 A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations Recruiting USA | GBR | FRA | ESP 2
NCT05887882 Phase I TGF-beta-imprinted NK cells Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Brain Tumors (PNOC028) Not yet recruiting USA 0