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Drug Name BGBA1217
Trade Name
Synonyms BGB-A1217|BGB A1217|Ociperlimab
Drug Descriptions

BGBA1217 is a monoclonal antibody that binds to TIGIT and blocks its interaction with Nectin-2 (CD112) and Nectin-like protein 5 (CD155), which results in increased interaction of CD112 and CD155 with the co-stimulatory receptor CD226 and activation of downstream signaling, potentially inducing immune response against tumor cells (NCI Thesaurus).

DrugClasses TIGIT Antibody 10
CAS Registry Number NA
NCIT ID C170906

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BGBA1217 BGBA1217 0 0
BGBA1217 + Carboplatin + Etoposide + Tislelizumab BGBA1217 Carboplatin Etoposide Tislelizumab 0 1
BGBA1217 + Carboplatin + Nab-paclitaxel + Tislelizumab BGBA1217 Carboplatin Nab-paclitaxel Tislelizumab 0 1
BGBA1217 + Carboplatin + Paclitaxel + Tislelizumab BGBA1217 Carboplatin Paclitaxel Tislelizumab 0 1
BGBA1217 + Carboplatin + Pemetrexed Disodium + Tislelizumab BGBA1217 Carboplatin Pemetrexed Disodium Tislelizumab 0 1
BGBA1217 + Cisplatin + Etoposide + Tislelizumab BGBA1217 Cisplatin Etoposide Tislelizumab 0 1
BGBA1217 + Cisplatin + Pemetrexed Disodium + Tislelizumab BGBA1217 Cisplatin Pemetrexed Disodium Tislelizumab 0 1
BGBA1217 + Tislelizumab BGBA1217 Tislelizumab 0 6


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