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Gene | BRIP1 |
Variant | G690R |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | BRIP1 G690R does not lie within any known functional domains of the Brip1 protein (UniProt.org). G690R does not confer resistance to interstrand crosslinking agents in a BRIP1-deficient cell line in culture (PMID: 33619228), and therefore, is predicted to lead to a loss of Brip1 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
BRIP1 mutant BRIP1 inact mut BRIP1 G690R |
Transcript | NM_032043.3 |
gDNA | chr17:g.61776430C>T |
cDNA | c.2068G>A |
Protein | p.G690R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_047436896.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_047436891.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_047436897.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_011525335.4 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_047436899.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_011525335.3 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
NM_032043.2 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_047436892.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
NM_032043.3 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_047436900.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
XM_047436901.1 | chr17:g.61776430C>T | c.2068G>A | p.G690R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRIP1 inact mut | prostate cancer | sensitive | Olaparib | Guideline | Actionable | Lynparza (olaparib) is included in guidelines as second-line therapy post androgen receptor-directed therapy for patients with metastatic castration-resistant prostate cancer harboring pathogenic mutations in BRIP1 (NCCN.org). | detail... |
BRIP1 inact mut | prostate cancer | sensitive | Olaparib | FDA approved - On Companion Diagnostic | Actionable | In a Phase III trial (PROfound) that supported FDA approval, Lynparza (olaparib) treatment significantly improved median imaging-based progression-free survival (5.8 vs 3.5 mo, HR 0.49, p<0.001) compared to control in patients with metastatic castration-resistant prostate cancer who progressed on hormone therapy and harbored deleterious or suspected deleterious mutations in homologous recombination repair genes, including BRIP1 (PMID: 32343890; NCT02987543). | detail... 32343890 detail... |
BRIP1 inact mut | prostate cancer | predicted - sensitive | Abiraterone + Niraparib + Prednisone | Phase III | Actionable | In a Phase III trial (MAGNITUDE), Zejula (niraparib) in combination with Zytiga (abiraterone) and Adasone (prednisone) (AAP) improved radiographic progression-free survival (HR 0.59) compared to placebo and AAP in patients with metastatic castration-resistant prostate cancer harboring inactivating mutations in the homologous recombination repair (HRR)-Fanconi pathway (BRIP1, FANCA, PALB2), with a HR of 0.23 in patients with BRIP1 mutations (J Clin Oncol 40, no. 16_suppl (June 01, 2022) 5020; NCT03748641). | detail... |
BRIP1 inact mut | prostate cancer | predicted - sensitive | Rucaparib | Case Reports/Case Series | Actionable | In a Phase II trial (TRITON2), 1 of 2 patients with metastatic castrate-resistant prostate cancer harboring deleterious BRIP1 alterations demonstrated a PSA response and partial radiographic response after treatment with Rubraca (rucaparib), which were ongoing at the time of visit cutoff (PMID: 32086346; NCT02952534). | 32086346 |
BRIP1 mutant | ovarian cancer | not applicable | N/A | Guideline | Risk Factor | Germline BRIP1 mutations are associated with increased risk of developing ovarian cancer (NCCN.org). | detail... |