Therapy Detail

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Therapy Name Cisplatin + Docetaxel + Fluorouracil + Toripalimab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cisplatin Platinol CDDP Chemotherapy - Platinum 6 Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Docetaxel Taxotere RP56976 Antimicrotubule Agent 12 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558).
Fluorouracil Adrucil 5-FU Chemotherapy - Antimetabolite 11 Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov).
Toripalimab JS001|JS-001|TAB001 Immune Checkpoint Inhibitor 94 PD-L1/PD-1 antibody 63 Toripalimab (JS001) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response and decreased tumor growth (PMID: 28317872; PMID: 32277740, PMID: 32406293).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown head and neck squamous cell carcinoma not applicable Cisplatin + Docetaxel + Fluorouracil + Toripalimab Phase II Actionable In a Phase II trial, Toripalimab (JS001) in combination with Taxotere (docetaxel), Adrucil (fluorouracil), and Platinol (cisplatin) resulted in an objective response rate of 33.3% (1/3) and a disease control rate of 100% (3/3) in patients with metastatic head and neck squamous cell carcinoma, with a median duration of response of 7.1 months (J Clin Oncol 38: 2020 (suppl; abstr e15083); NCT02915432). detail...

Filtering

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status


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