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|Therapy Name||Navitoclax + PLX4720|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Navitoclax||ABT-263||BCL-XL inhibitor 11 BCL2 inhibitor 18||Navitoclax (ABT-263) is a BCL2, BCL-XL, and BCL-W inhibitor, which may enhance the efficacy of chemotherapeutics (PMID: 25787766, PMID: 32513939).|
|PLX4720||PLX-4720|PLX 4720||BRAF Inhibitor 20||PLX4720 is a 7-azaindole derivative and RAF kinase inhibitor with greater affinity for BRAF V600E than BRAF wild-type, which may induce cell cycle arrest and apoptosis, and lead to tumor growth inhibition and regression (PMID: 18287029).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E||melanoma||sensitive||Navitoclax + PLX4720||Preclinical - Cell line xenograft||Actionable||In a preclinical study, PLX4720 and navitoclax (ABT-263) worked synergistically to inhibit growth and increase apoptosis of BRAF V600E mutant melanoma cells in culture and in xenografts (PMID: 24983357).||24983357|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|