Therapy Detail

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Therapy Name HL-085
Synonyms
Therapy Description

HL-085 is a MEK inhibitor that may inhibit proliferation of tumor cells (Cancer Res 2019;79(13 Suppl):Abstract nr 4753).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
HL-085 HL085|HL 085 MEK inhibitor (Pan) 23 HL-085 is a MEK inhibitor that may inhibit proliferation of tumor cells (Cancer Res 2019;79(13 Suppl):Abstract nr 4753).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G12S melanoma predicted - sensitive HL-085 Case Reports/Case Series Actionable In a Phase I trial, HL-085 treatment demonstrated safety and preliminary efficacy in patients with advanced melanoma harboring NRAS mutations, resulting in a partial response in a patient harboring NRAS G12S who remained on treatment for 36 weeks (PMID: 36600247; NCT03973151). 36600247
NRAS act mut melanoma predicted - sensitive HL-085 Phase I Actionable In a Phase I trial, HL-085 treatment demonstrated acceptable tolerability and resulted in an objective response rate (ORR) of 14.3% (6/42; all partial responses), a disease control rate (DCR) of 78.6%, and a median progression-free survival (PFS) of 3.0 months in patients with advanced melanoma harboring NRAS mutations, and an ORR of 26.7% (4/15), a DCR of 86.7%, and median PFS of 3.6 months at the recommended Phase II dose (PMID: 36600247; NCT03973151). 36600247
NRAS Q61R melanoma predicted - sensitive HL-085 Case Reports/Case Series Actionable In a Phase I trial, HL-085 treatment demonstrated safety and preliminary efficacy in patients with advanced melanoma harboring NRAS mutations, resulting in an objective response rate of 37.5% (3/8), a disease control rate of 75% (6/8), and a median progression-free survival of 114.0 days in patients harboring NRAS Q61R at the recommended Phase II dose (PMID: 36600247; NCT03973151). 36600247

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04683354 Phase I HL-085 Phase I Study of HL-085 in Patients With Advanced Solid Tumor Tumors Completed USA 0
NCT03976050 Phase I HL-085 Phase I Study of HL-085 in Patients With Advanced Solid Tumors Terminated USA 0


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