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ID DOID:50523
Name adult T-cell leukemia
Definition A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia lymphoid leukemia acute leukemia acute lymphoblastic leukemia T-cell acute lymphoblastic leukemia T-cell lymphoblastic leukemia/lymphoma adult T-cell leukemia

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Alemtuzumab adult T-cell leukemia not applicable detail...
NRAS G13V 3144 adult T-cell leukemia sensitive detail...
NRAS G13D 3144 adult T-cell leukemia sensitive detail...
FBXW7 positive JQ1 adult T-cell leukemia predicted - sensitive detail...
Unknown unknown JQ1 adult T-cell leukemia not applicable detail...
Unknown unknown Birabresib adult T-cell leukemia not applicable detail...
FBXW7 W425R JQ1 adult T-cell leukemia resistant detail...
FBXW7 W425R Birabresib adult T-cell leukemia resistant detail...
FBXW7 S462P JQ1 adult T-cell leukemia resistant detail...
FBXW7 S462P Birabresib adult T-cell leukemia resistant detail...
FBXW7 H468R JQ1 adult T-cell leukemia resistant detail...
FBXW7 H468R Birabresib adult T-cell leukemia resistant detail...
Unknown unknown Dinaciclib adult T-cell leukemia no benefit detail...
Unknown unknown Sorafenib adult T-cell leukemia no benefit detail...
FBXW7 S462P JQ1 + PLX8394 adult T-cell leukemia sensitive detail...
FBXW7 S462P JQ1 + Ulixertinib adult T-cell leukemia sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01712659 Phase II Ruxolitinib Ruxolitinib for Adult T-Cell Leukemia Recruiting USA 0
NCT02580552 Phase I MRG-106 Safety, Tolerability and Pharmacokinetics of MRG-106 in Patients With Mycosis Fungoides (MF), CLL, DLBCL or ATLL Completed USA 0
NCT02588651 Phase II Brentuximab vedotin A Phase II Study of Single Agent Brentuximab Vedotin in Relapsed/Refractory CD30 Low (<10%) Mature T Cell Lymphoma (TCL) Recruiting USA 0
NCT02689453 Phase I Alemtuzumab + rhIL-15 Subcutaneous Recombinant Human IL-15 (s.c. rhIL-15) and Alemtuzumab for People With Refractory or Relapsed Chronic and Acute Adult T-cell Leukemia (ATL) Active, not recruiting USA 0
NCT02732275 Phase I DS-3201b DS-3201b in Participants With Lymphomas Recruiting USA 1
NCT02737046 Phase II Interferon alpha-2b Peginterferon alfa-2b Belinostat + Zidovudine Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Recruiting USA 0
NCT03075553 Phase II Nivolumab Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Terminated USA 0
NCT03081910 Phase I CD5 CAR T cells Cyclophosphamide + Fludarabine Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen (MAGENTA) Recruiting USA 0
NCT03264131 Phase II Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Etoposide + Prednisone BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma Recruiting USA 0
NCT03829540 Phase I CD4CAR CD4CAR for CD4+ Leukemia and Lymphoma Recruiting USA 0
NCT04185220 Phase I Mogamulizumab + rhIL-15 Phase I Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for People With Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome Active, not recruiting USA 0
NCT04283097 Phase I KPG-818 Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects Recruiting USA 0
NCT04639843 Phase I Azacitidine + Doxorubicin + Duvelisib + Romidepsin Doxorubicin, CC-(486) (5-azacitidine), Romidepsin, and Duvelisib (hARD) for T-cell Lymphoma Not yet recruiting USA 0
NCT04747236 Phase II Pralatrexate Belinostat Azacitidine + Romidepsin Gemcitabine Romidepsin A Randomized, Phase IIB, Multicenter, Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in Patients With Relapse or Refractory Peripheral T-cell Lymphoma (PTCL) Recruiting USA 0
NCT04848064 Phase I Cyclophosphamide + Fludarabine Mogamulizumab Third-Party Natural Killer Cells and Mogamulizumab for the Treatment of Relapsed or Refractory Cutaneous T-cell Lymphomas or Adult T-Cell Leukemia/Lymphoma Not yet recruiting USA 0