Disease Detail


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ID DOID:5289
Name uterus leiomyosarcoma
Definition A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer organ system cancer reproductive organ cancer female reproductive organ cancer uterine cancer uterine corpus cancer uterine corpus sarcoma uterus leiomyosarcoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FGFR1 over exp PD173074 uterus leiomyosarcoma sensitive detail...
FGFR1 over exp AZD4547 uterus leiomyosarcoma sensitive detail...
FGFR1 over exp Infigratinib uterus leiomyosarcoma sensitive detail...
FGFR1 positive PD173074 uterus leiomyosarcoma decreased response detail...
FGFR1 positive AZD4547 uterus leiomyosarcoma decreased response detail...
FGFR1 positive Infigratinib uterus leiomyosarcoma decreased response detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02203760 Phase II Pazopanib Gemcitabine + Pazopanib Pazopanib vs. Pazopanib Plus Gemcitabine (PazoDoble) Recruiting DEU 0
NCT02428192 Phase II Nivolumab Nivolumab in Treating Patients With Advanced Uterine Leiomyosarcoma Active, not recruiting USA 0
NCT02963831 Phase Ib/II Durvalumab + ONCOS-102 A Phase 1/2 Study to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Completed USA 0
NCT03241745 Phase II Nivolumab A Study of Nivolumab in Selected Uterine Cancer Patients Active, not recruiting USA 0
NCT03548428 Phase II Atezolizumab Stereotaxic Body Irradiation of Oligometastase in Sarcoma (Stereosarc) (Stereosarc) Recruiting FRA 0
NCT03880019 Phase II Olaparib + Temozolomide Olaparib and Temozolomide in Treating Patients With Advanced, Metastatic, or Unresectable Uterine Leiomyosarcoma Active, not recruiting USA 0
NCT03926936 Phase II Fulvestrant FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study (FUCHSia) Recruiting BEL 0
NCT04028063 Phase II Balstilimab + Doxorubicin + Zalifrelimab Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas Recruiting USA 0
NCT04200443 Phase II Cabozantinib + Temozolomide Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma Active, not recruiting USA 0
NCT04969887 Phase II Ipilimumab + Nivolumab Combination Immunotherapy in Rare Cancers Under InvesTigation (MOST-CIRCUIT) Recruiting AUS 1
NCT05633381 Phase II Pazopanib + Trabectedin Olaparib + Temozolomide Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working Recruiting USA 0