Disease Detail

ID DOID:8632
Name Kaposi's sarcoma
Definition A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).
Source DiseaseOntology.org
Alt Ids DOID:12776 DOID:12770 DOID:7239 DOID:12767 DOID:12778 DOID:12766 DOID:12777 DOID:12771 DOID:12762 DOID:6480 DOID:12761 DOID:12772 DOID:12768 DOID:12764 DOID:12775 DOID:8631 DOID:12774
Path disease disease of cellular proliferation cancer organ system cancer musculoskeletal system cancer connective tissue cancer Kaposi's sarcoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Clinical Trial Phase Therapies Title Recruitment Status
NCT00092222 Phase II Sirolimus Alpha 2 Interferon Cyclophosphamide + Doxorubicin + Etoposide + Prednisone + Vincristine Rituximab Bortezomib Pegylated liposomal-doxorubicin Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity Recruiting
NCT00923936 Phase II Bevacizumab + Pegylated liposomal-doxorubicin Pilot Study of Liposomal Doxorubicin Combined With Bevacizumab Followed by Bevacizumab Monotherapy in Adults With Advanced Kaposi s Sarcoma Completed
NCT02137564 Phase II PF-03084014 Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma Withdrawn
NCT02408861 Phase I Ipilimumab + Nivolumab Nivolumab and Ipilimumab in Treating Patients With Advanced HIV Associated Solid Tumors Recruiting
NCT02595866 Phase I Pembrolizumab Pembrolizumab in Treating Patients With HIV and Relapsed, Refractory, or Disseminated Malignant Neoplasms Recruiting
NCT03316274 Phase I Nivolumab Intra-lesional Nivolumab Therapy for Limited Cutaneous Kaposi Sarcoma Recruiting
NCT03993106 Phase II sEphB4-HSA A Study of sEphB4-HSA in Kaposi Sarcoma Not yet recruiting