Gene Detail

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Gene Symbol CDKN2A
Synonyms ARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4A | MLM | MTS-1 | MTS1 | P14 | P14ARF | P16 | P16-INK4A | P16INK4 | P16INK4A | P19 | P19ARF | TP16
Gene Description CDKN2A, cyclin-dependent kinase inhibitor 2A, is a tumor suppressor (PMID: 30562755) that encodes p16 and p14ARF from alternate reading frames, which function to inhibit Cdk4 and Cdk6 and regulate Tp53 activity to promote cell-cycle arrest (PMID: 23875803, PMID: 17055429, PMID: 27428416). CDKN2A germline mutations are associated with familial atypical multiple mole melanoma and somatic mutations are highest in pancreatic (PMID: 32273725), HNSCC, NSCLC, and melanoma (PMID: 27283171), and deletion of CDKN2A may be prognostic in IDH-mutant glioma (PMID: 32385699).

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Molecular Profile Protein Effect Treatment Approaches
CDKN2A A100S no effect - predicted
CDKN2A A102fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A A102V unknown
CDKN2A A127fs unknown
CDKN2A A148T no effect
CDKN2A A20E unknown
CDKN2A A20P loss of function - predicted
CDKN2A A21P unknown
CDKN2A A36G unknown
CDKN2A A36P loss of function - predicted
CDKN2A A57T unknown
CDKN2A A57V unknown
CDKN2A A60fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A A60R loss of function
CDKN2A A60V loss of function
CDKN2A A68fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A A68T unknown
CDKN2A A73D unknown
CDKN2A A76fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A A76T unknown
CDKN2A amp no effect
CDKN2A C72* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A C72fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A C72S unknown
CDKN2A D108G unknown
CDKN2A D108H loss of function - predicted
CDKN2A D108N unknown
CDKN2A D108V unknown
CDKN2A D108Y loss of function - predicted
CDKN2A D125fs unknown
CDKN2A D14G unknown
CDKN2A D14N unknown
CDKN2A D74N loss of function - predicted
CDKN2A D74V unknown
CDKN2A D74Y loss of function - predicted
CDKN2A D84A unknown
CDKN2A D84G loss of function
CDKN2A D84H loss of function
CDKN2A D84N loss of function
CDKN2A D84V loss of function
CDKN2A D84Y loss of function
CDKN2A del loss of function CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
EML4 - ALK CDKN2A del FGFR1 T141R SMAD4 Q83*
CDKN2A del RB1 pos
CDKN2A E119* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A E119K unknown
CDKN2A E120* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A E120D unknown
CDKN2A E33fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A E69* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A E69G loss of function
CDKN2A E88* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A E88K loss of function
CDKN2A F90fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A G101V loss of function - predicted
CDKN2A G101W loss of function
CDKN2A G111D unknown
CDKN2A G23A no effect - predicted
CDKN2A G23C loss of function - predicted
CDKN2A G23D loss of function
CDKN2A G23fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A G23R loss of function - predicted
CDKN2A G23S unknown
CDKN2A G23V loss of function - predicted
CDKN2A G35A loss of function
CDKN2A G35E no effect - predicted
CDKN2A G35R no effect - predicted
CDKN2A G35V loss of function
CDKN2A G35W loss of function - predicted
CDKN2A G45S unknown
CDKN2A G67R loss of function
CDKN2A G67S unknown
CDKN2A H123Q no effect - predicted
CDKN2A H83D unknown
CDKN2A H83N loss of function - predicted
CDKN2A H83Q unknown
CDKN2A H83R unknown
CDKN2A H83Y loss of function - predicted
CDKN2A H98P loss of function
CDKN2A I49S loss of function
CDKN2A inact mut loss of function
CDKN2A L130R unknown
CDKN2A L16fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A L16P loss of function
CDKN2A L31R loss of function
CDKN2A L31V unknown
CDKN2A L32P loss of function
CDKN2A L62_E69del unknown
CDKN2A L65fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A L65P unknown
CDKN2A L78fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A L94P loss of function - predicted
CDKN2A L97R loss of function
CDKN2A LOH unknown
CDKN2A loss loss of function CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A loss NRAS mut
CDKN2A loss NRAS Q61K
CDKN2A loss PIK3CA act mut
CDKN2A loss PIK3CA E545K PIK3CA amp
CDKN2A loss PIK3CA E542K PIK3CA amp
CDKN2A M52fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A M52I unknown
CDKN2A M52L unknown
CDKN2A M52R unknown
CDKN2A M53I loss of function
CDKN2A mutant unknown
CDKN2A mut PIK3CA mut
BRAF V600E CDKN2A mut
CDKN2A mut NRAS act mut
CDKN2A N42fs loss of function - predicted
CDKN2A N42H unknown
CDKN2A N71I loss of function
CDKN2A N71K loss of function
CDKN2A N71S loss of function
CDKN2A negative loss of function
CDKN2A over exp no effect
CDKN2A over exp SMARCB1 neg
CDKN2A P114H unknown
CDKN2A P114L loss of function
CDKN2A P114S loss of function
CDKN2A P114T unknown
CDKN2A P48L loss of function - predicted
CDKN2A P48R unknown
CDKN2A P70T unknown
CDKN2A P75S unknown
CDKN2A P81fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A P81L loss of function
CDKN2A P81S unknown
CDKN2A P81T loss of function - predicted
CDKN2A positive unknown
CDKN2A pos RB1 inact mut
CDKN2A Q50* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A Q50fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A Q50H unknown
CDKN2A Q50P loss of function - predicted
CDKN2A Q50R unknown
CDKN2A R112G loss of function
CDKN2A R112P unknown
CDKN2A R124C unknown
CDKN2A R124H no effect
CDKN2A R128fs unknown
CDKN2A R128W loss of function - predicted
CDKN2A R131C unknown
CDKN2A R24P loss of function
CDKN2A R58* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A R58fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A R80* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A R80L loss of function - predicted
CDKN2A R80P unknown
CDKN2A R80Q unknown
CDKN2A R87L loss of function
CDKN2A R87P loss of function
CDKN2A R87W loss of function
CDKN2A R99P loss of function - predicted
CDKN2A rearrange unknown
CDKN2A S12* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A S43I unknown
CDKN2A S56fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A S56I loss of function
CDKN2A S56N unknown
CDKN2A T77fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A T77P loss of function
CDKN2A T79fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A V106fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A V126D loss of function - predicted
CDKN2A V51I unknown
CDKN2A V59fs loss of function - predicted
CDKN2A V82E unknown
CDKN2A V82fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A V82M unknown
CDKN2A W110* loss of function CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A W110fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A W15* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A W15fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A wild-type no effect
CDKN2A Y129* unknown
CDKN2A Y44* loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A Y44fs loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor
CDKN2A Y44Lfs*76 loss of function - predicted CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor