Gene Detail

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Gene Symbol FGFR2
Synonyms BBDS | BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | JWS | K-SAM | KGFR | TK14 | TK25
Gene Description FGFR2, fibroblast growth factor receptor 2, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR2 through activating mutations, fusions, and amplification increases cell proliferation and tumorigenesis (PMID: 22508544) and is observed in prostate (PMID: 30761180), breast, lung, uterine, and ovarian cancers (PMID: 29104507), while FGFR2 amplification (PMID: 31076567) and overexpression (PMID: 30662521) is commonly observed in gastric cancer.

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 A264T unknown
FGFR2 A314D unknown
FGFR2 A315S unknown
FGFR2 A315T unknown
FGFR2 A344G unknown
FGFR2 A344P unknown
FGFR2 A389T no effect - predicted
FGFR2 A648T loss of function
FGFR2 A97T unknown
FGFR2 act mut gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 amp no effect FGFR Inhibitor (Pan) FGFR2 Antibody FGFR2 Inhibitor
FGFR2 fusion FGFR2 amp
FGFR1 amp FGFR2 amp
FGFR2 amp FGFR2 over exp
ERBB2 amp FGFR2 amp
FGFR2 - COL14A1 FGFR2 amp
FGFR2 - GAB2 FGFR2 amp
FGFR2 amp FGFR2 rearrange
FGFR2 amp FGFR2 mut
FGFR2 C278F unknown
FGFR2 C342F unknown
FGFR2 C342R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C342S unknown
FGFR2 C342Y gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C382R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C382R FGFR2 N550K
FGFR2 C382Y no effect - predicted
FGFR2 C383R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C383R FGFR2 N550K
FGFR2 D101Y gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D138N unknown
FGFR2 D247Y unknown
FGFR2 D283N unknown
FGFR2 D304N no effect - predicted
FGFR2 D336N unknown
FGFR2 D479N unknown
FGFR2 D530N loss of function
FGFR2 D602E unknown
FGFR2 D650A gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D650G loss of function - predicted
FGFR2 D650I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D650L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D650V gain of function - predicted
FGFR2 dec exp no effect
FGFR2 E116K unknown
FGFR2 E160A unknown
FGFR2 E219K unknown
FGFR2 E470Q unknown
FGFR2 E475K unknown
FGFR2 E565A gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - ZMYM4 FGFR2 N549H FGFR2 N549K FGFR2 V564F FGFR2 E565A FGFR2 K659M
FGFR2 - OPTN FGFR2 N549H FGFR2 V564F FGFR2 E565A FGFR2 L617V FGFR2 K641R
FGFR2 - SHTN1 FGFR2 E565A
FGFR2 - SHTN1 FGFR2 E565A FGFR2 L617M
FGFR2 - TACC3 FGFR2 E565A
FGFR2 E565G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E566A gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - ZMYM4 FGFR2 N550H FGFR2 N550K FGFR2 V565F FGFR2 E566A FGFR2 K660M
FGFR2 - INA FGFR2 V565L FGFR2 E566A
FGFR2 fusion FGFR2 E566A
FGFR2 E566G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E574K unknown
FGFR2 E596K unknown
FGFR2 E636* loss of function - predicted
FGFR2 E636K unknown
FGFR2 E695K unknown
FGFR2 E718K unknown
FGFR2 E731K unknown
FGFR2 E777K unknown
FGFR2 F276C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 F276V unknown
FGFR2 F386_A389del no effect - predicted
FGFR2 - AFF3 gain of function
FGFR2 - AHCYL1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - BFSP2 unknown
FGFR2 - BICC1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - BICC1 FGFR2 V564F
FGFR2 - BICC1 FGFR2 - CASP7
FGFR2 - BICC1 FGFR2 - OFD1
FGFR2 - CASP7 gain of function
FGFR2 - CCAR2 unknown
FGFR2 - CCDC6 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - CCDC6 FGFR2 - TACC3
FGFR2 - CCDC6 FGFR3 - TACC3
FGFR2 - CIT unknown
FGFR2 - CLIP1 gain of function - predicted
FGFR2 - CLIP1 FGFR2 N549H
FGFR2 - COL14A1 unknown
FGFR2 - DDX21 unknown
FGFR2 - DNM3 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - EIF4A2 unknown
FGFR2 - FAM76A gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - FN1 unknown
FGFR2 - FRK unknown
FGFR2 - GAB2 unknown
FGFR2 - INA gain of function
FGFR2 - INA FGFR2 M538I FGFR2 N550H FGFR2 N550T FGFR2 L618V FGFR2 H683L
FGFR2 - KIAA1217 unknown
FGFR2 - MBIP unknown
FGFR2 - NRAP unknown
FGFR2 - NRAP FGFR2 N550K
FGFR2 - OFD1 gain of function
FGFR2 - OGA unknown
FGFR2 - OPTN gain of function - predicted
FGFR2 - PPHLN1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - ROCK1 unknown
FGFR2 - SH3GLB1 unknown
FGFR2 - SHTN1 gain of function - predicted
FGFR2 - SHTN1 FGFR2 L617M
FGFR2 - SORBS1 unknown
FGFR2 - SORBS1 FGFR2 K660M FGFR2 K715R
FGFR2 - SORBS1 FGFR2 V565F
FGFR2 - TACC1 unknown
FGFR2 - TACC2 unknown
FGFR2 - TACC3 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - TACC3 FGFR2 N549H
FGFR2 - TBC1D1 unknown
FGFR2 - TNS1 unknown
FGFR2 - TTC28 unknown
FGFR2 - WDR11 unknown
FGFR2 - ZMYM4 unknown
FGFR2 - ZMYM4 FGFR2 V563L
FGFR2 fusion unknown
FGFR2 fusion FGFR3 - TACC3
FGFR2 fusion FGFR2 V564F
FGFR2 fusion FGFR1 amp
FGFR2 fusion FGFR2 M538I
FGFR2 fusion FGFR2 N550H
FGFR2 fusion FGFR2 N550K
FGFR2 fusion FGFR2 V565F
FGFR2 fusion FGFR2 L618V
FGFR2 fusion FGFR2 K660M
FGFR2 fusion FGFR2 H683L
FGFR2 fusion FGFR2 K715R
FGFR2 G183fs loss of function - predicted
FGFR2 G227E unknown
FGFR2 G227R unknown
FGFR2 G271E loss of function
FGFR2 G272V unknown
FGFR2 G302W unknown
FGFR2 G305R unknown
FGFR2 G338R unknown
FGFR2 G384E unknown
FGFR2 G462E unknown
FGFR2 G583R unknown
FGFR2 G583V unknown
FGFR2 G583W unknown
FGFR2 G663E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 G690R unknown
FGFR2 G701S unknown
FGFR2 H167_N173del gain of function - predicted
FGFR2 H167_N173del FGFR2 L617F
FGFR2 H213Y unknown
FGFR2 H544Q unknown
FGFR2 H683L unknown
FGFR2 I380V unknown
FGFR2 I547D unknown
FGFR2 I547V gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I548V gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I590M unknown
FGFR2 I642T unknown
FGFR2 I642V loss of function
FGFR2 inact mut loss of function
FGFR2 K292M no effect - predicted
FGFR2 K310R no effect - predicted
FGFR2 K310R FGFR2 N549K
FGFR2 K310R FGFR2 N550K
FGFR2 K405E unknown
FGFR2 K420I unknown
FGFR2 K517R loss of function
FGFR2 K525E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K526E gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K641N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K641R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K642R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659M gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K660E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K660M unknown
FGFR2 K660N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K714R unknown
FGFR2 K715R unknown
FGFR2 L258F no effect - predicted
FGFR2 L397M unknown
FGFR2 L551I unknown
FGFR2 L617F unknown
FGFR2 L617M unknown
FGFR2 L617V gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L618M gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L618V gain of function - predicted
FGFR2 L761Tfs*55 unknown
FGFR2 L770V unknown
FGFR2 L772F unknown
FGFR2 M186T no effect - predicted
FGFR2 M391R unknown
FGFR2 M535T unknown
FGFR2 M536I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M537A loss of function - predicted
FGFR2 M537I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M538I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M538R unknown
FGFR2 M540A loss of function - predicted
FGFR2 M584V unknown
FGFR2 M640I unknown
FGFR2 mutant unknown
FGFR2 N211I unknown
FGFR2 N549D unknown
FGFR2 N549H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550S gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 over exp no effect FGFR Inhibitor (Pan) FGFR2 Inhibitor GSK3052230
FGFR2 P253L unknown
FGFR2 P253R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 P253S unknown
FGFR2 P256S unknown
FGFR2 P286S unknown
FGFR2 P303L unknown
FGFR2 P582L unknown
FGFR2 P708S unknown
FGFR2 P775L unknown
FGFR2 positive unknown
FGFR1 pos FGFR2 pos
FGFR2 pos FGFR3 pos
FGFR2 Q212K unknown
FGFR2 Q259* no effect - predicted
FGFR2 Q289P unknown
FGFR2 Q620K unknown
FGFR2 R165W unknown
FGFR2 R203C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R203H unknown
FGFR2 R210Q unknown
FGFR2 R251* loss of function - predicted
FGFR2 R251Q loss of function
FGFR2 R255Q loss of function - predicted
FGFR2 R330W unknown
FGFR2 R625Q unknown
FGFR2 R625T unknown
FGFR2 R664W loss of function - predicted
FGFR2 R678G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R6P unknown
FGFR2 R759Q unknown
FGFR2 rearrange unknown
FGFR2 S24F unknown
FGFR2 S252F unknown
FGFR2 S252L unknown
FGFR2 S252W gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S267P unknown
FGFR2 S267_D273dup gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S347C unknown
FGFR2 S354C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S372C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S372F unknown
FGFR2 S436F no effect - predicted
FGFR2 S57L unknown
FGFR2 S587C unknown
FGFR2 S688F unknown
FGFR2 S780A gain of function - predicted
FGFR2 S780D gain of function - predicted
FGFR2 S780L gain of function - predicted
FGFR2 S799A no effect - predicted
FGFR2 T341P gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 T370R unknown
FGFR2 T394A no effect - predicted
FGFR2 T730S no effect
FGFR2 T764fs unknown
FGFR2 T786K unknown
FGFR2 V248D unknown
FGFR2 V392A unknown
FGFR2 V392M no effect - predicted
FGFR2 V395D unknown
FGFR2 V514L unknown
FGFR2 V563L gain of function - predicted
FGFR2 V564F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564M unknown
FGFR2 V564T no effect - predicted
FGFR2 V565F gain of function - predicted
FGFR2 V565I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V565L gain of function - predicted
FGFR2 V755I no effect
FGFR2 V77M unknown
FGFR2 W290* loss of function - predicted
FGFR2 W290C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W290_I291delinsC gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 wild-type no effect
ERBB2 amp FGFR2 wild-type
FGFR2 Y281C unknown
FGFR2 Y340C unknown
FGFR2 Y340H unknown
FGFR2 Y375C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 Y376C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 Y588D unknown
FGFR2 Y769* unknown