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Gene Symbol FGFR2
Synonyms BBDS | BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | JWS | K-SAM | KGFR | TK14 | TK25
Gene Description FGFR2, fibroblast growth factor receptor 2, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR2 through activating mutations, fusions, and amplification increases cell proliferation and tumorigenesis (PMID: 22508544) and is observed in prostate (PMID: 30761180), breast, lung, uterine, and ovarian cancers (PMID: 29104507), while FGFR2 amplification (PMID: 31076567) and overexpression (PMID: 30662521) is commonly observed in gastric cancer.

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 A264T gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 A314D unknown
FGFR2 A315C unknown
FGFR2 A315S unknown
FGFR2 A315T unknown
FGFR2 A344G unknown
FGFR2 A344P unknown
FGFR2 A371V no effect - predicted
FGFR2 A389T unknown
FGFR2 A553D unknown
BRAF V600E FGFR2 A553D
FGFR2 A648T loss of function
FGFR2 A67V gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 A97T unknown
FGFR2 act mut gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 amp no effect FGFR Inhibitor (Pan) FGFR2 Antibody FGFR2 Inhibitor
FGFR2 fusion FGFR2 amp
FGFR1 amp FGFR2 amp
FGFR2 amp FGFR2 over exp
FGFR2 rearrange FGFR2 amp
FGFR2 amp FGFR2 mut
FGFR2 K660N FGFR2 amp
FGFR2 M537I FGFR2 V564L FGFR2 amp
FGFR2 Y375C FGFR2 amp
FGFR2 G542A FGFR2 V564L FGFR2 amp
FGFR2 C278F unknown
FGFR2 C342F unknown
FGFR2 C342R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C342S unknown
FGFR2 C342Y gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C382R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C382R FGFR2 N550K
FGFR2 C382Y no effect - predicted
FGFR2 C383R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C383R FGFR2 N550K
FGFR2 C492F unknown
FGFR2 C62Y gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D101Y gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D138N unknown
FGFR2 D247Y unknown
FGFR2 D283N unknown
FGFR2 D304N no effect - predicted
FGFR2 D336N unknown
FGFR2 D471N no effect - predicted
FGFR2 D479N unknown
FGFR2 D530N loss of function
FGFR2 D602E unknown
FGFR2 D650A gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D650G loss of function - predicted
FGFR2 D650I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D650L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D650V gain of function - predicted
FGFR2 D650Y unknown
FGFR2 dec exp no effect
FGFR2 del exon5 unknown
FGFR2 del exon7 unknown
FGFR2 dup exon9-17 unknown
FGFR2 E116K unknown
FGFR2 E160A unknown
FGFR2 E160K gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E163K gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E219K unknown
FGFR2 E470Q unknown
FGFR2 E475K unknown
FGFR2 E565A gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W72C FGFR2 E565A
FGFR2 E565G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E566A gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 fusion FGFR2 E566A
FGFR2 E566G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E574K unknown
FGFR2 E596K no effect - predicted
FGFR2 E636* unknown
FGFR2 E636K unknown
FGFR2 E695K loss of function - predicted
FGFR2 E718K gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E731K unknown
FGFR2 E768* gain of function - predicted
FGFR2 E777K unknown
FGFR2 exon 5 del unknown
FGFR2 exon 7 del unknown
FGFR2 exon5 unknown
FGFR2 exon7 unknown
FGFR2 F276C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 F276I unknown
FGFR2 F276V unknown
FGFR2 F386_A389del no effect - predicted
FGFR2 fusion unknown FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 fusion FGFR2 V564F
FGFR2 fusion FGFR1 amp
FGFR2 fusion FGFR2 M538I
FGFR2 fusion FGFR2 N550H
FGFR2 fusion FGFR2 N550K
FGFR2 fusion FGFR2 V565F
FGFR2 fusion FGFR2 L618V
FGFR2 fusion FGFR2 K660M
FGFR2 fusion FGFR2 H683L
FGFR2 fusion FGFR2 K715R
FGFR2 G183fs loss of function - predicted
FGFR2 G227E unknown
FGFR2 G227R unknown
FGFR2 G271E loss of function
FGFR2 G272V unknown
FGFR2 G302W unknown
FGFR2 G305R no effect - predicted
FGFR2 G338R unknown
FGFR2 G364E gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 G384E unknown
FGFR2 G462E unknown
FGFR2 G542A unknown
FGFR2 G542E loss of function - predicted
FGFR2 G583R unknown
FGFR2 G583V unknown
FGFR2 G583W unknown
FGFR2 G613S no effect - predicted
FGFR2 G663E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 G690R unknown
FGFR2 G701S unknown
FGFR2 H167_N173del gain of function
FGFR2 H167_N173del FGFR2 L617F
FGFR2 H167_N173del FGFR2 L618F
BRAF L597Q FGFR2 H167_N173del FGFR2 L618F
BRAF L597Q FGFR2 H167_N173del FGFR2 N550K FGFR2 L618F NRAS Q61K
FGFR2 H213Y unknown
FGFR2 H242Y no effect - predicted
FGFR2 H416R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 H544Q gain of function - predicted
FGFR2 H683L unknown
FGFR2 I288_D304del gain of function - predicted
FGFR2 I288_E295delinsT unknown
FGFR2 I291_Y308del unknown
FGFR2 I380V unknown
FGFR2 I422V gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I547D unknown
FGFR2 I547V gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I548V gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I548Wfs*8 gain of function - predicted
FGFR2 I590M unknown
FGFR2 I642T unknown
FGFR2 I642V loss of function
FGFR2 inact mut loss of function
FGFR2 K292M no effect - predicted
FGFR2 K310R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K310R FGFR2 N549K
FGFR2 K310R FGFR2 N550K
FGFR2 K405E unknown
FGFR2 K41E no effect - predicted
FGFR2 K420I unknown
FGFR2 K517R loss of function
FGFR2 K525E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K526E gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K545del gain of function - predicted
FGFR2 K641N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K641R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K642R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659M gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659Q unknown
FGFR2 K660E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K660M unknown
FGFR2 K660N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K714R unknown
FGFR2 K715R unknown
FGFR2 L258F no effect - predicted
FGFR2 L33S unknown
FGFR2 L397M unknown
FGFR2 L550F unknown
FGFR2 L551F unknown
FGFR2 L551I unknown
FGFR2 L552F unknown
FGFR2 L560F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L617F unknown
FGFR2 L617M unknown
FGFR2 L617V gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L618F unknown
FGFR2 L618M gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L618V gain of function - predicted
FGFR2 L634V unknown
FGFR2 L761Tfs*55 unknown
FGFR2 L770V unknown
FGFR2 L772F unknown
FGFR2 L776Rfs*6 gain of function - predicted
FGFR2 M121V unknown
FGFR2 M186T loss of function - predicted
FGFR2 M391R unknown
FGFR2 M535T unknown
FGFR2 M536I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M537A loss of function - predicted
FGFR2 M537I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M538I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M538L unknown
FGFR2 M538R unknown
FGFR2 M539L unknown
FGFR2 M540A loss of function - predicted
FGFR2 M584V unknown
FGFR2 M640I no effect - predicted
FGFR2 M722I loss of function - predicted
FGFR2 mutant unknown
FGFR2 N211I unknown
FGFR2 N549D gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549S gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550D unknown
FGFR2 N550H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550K PIK3CA I20M PIK3CA P539R PTEN R130Q PTEN T321fs
FGFR2 N550S gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N631_M640del gain of function - predicted
FGFR2 N652S unknown
FGFR2 N82K gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 over exp no effect FGFR Inhibitor (Pan) FGFR2 Inhibitor GSK3052230
FGFR2 P253L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 P253R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 P253S unknown
FGFR2 P256S unknown
FGFR2 P286S unknown
FGFR2 P303L no effect - predicted
FGFR2 P582L no effect - predicted
FGFR2 P708S loss of function - predicted
FGFR2 P775L unknown
FGFR2 P781* gain of function - predicted
FGFR2 positive unknown
FGFR1 pos FGFR2 pos
FGFR2 pos FGFR3 pos
FGFR2 Q212K gain of function - predicted
FGFR2 Q259* loss of function - predicted
FGFR2 Q289P unknown
FGFR2 Q620K unknown
FGFR2 Q746L unknown
FGFR2 R165W unknown
FGFR2 R178C unknown
FGFR2 R203C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R203H unknown
FGFR2 R210Q unknown
FGFR2 R251* loss of function - predicted
FGFR2 R251Q loss of function
FGFR2 R255Q loss of function - predicted
FGFR2 R255W unknown
FGFR2 R255W FGFR3 S249C FGFR3 V553M FGFR3 K650M
FGFR2 R330W no effect - predicted
FGFR2 R399* loss of function - predicted
FGFR2 R399Q gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R625Q loss of function - predicted
FGFR2 R625T unknown
FGFR2 R664W unknown
FGFR2 R678G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R6P no effect - predicted
FGFR2 R759Q unknown
FGFR2 rearrange unknown FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S24F unknown
FGFR2 S252F unknown
FGFR2 S252L unknown
FGFR2 S252W unknown FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S267P unknown
FGFR2 S267_D273dup gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S347C unknown
FGFR2 S354C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S372C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S372F unknown
FGFR2 S436F no effect - predicted
FGFR2 S57L unknown
FGFR2 S587C unknown
FGFR2 S688F unknown
FGFR2 S780A gain of function - predicted
FGFR2 S780D gain of function - predicted
FGFR2 S780L gain of function - predicted
FGFR2 S782Rfs*3 gain of function - predicted
FGFR2 S789* gain of function - predicted
FGFR2 S791T gain of function - predicted
FGFR2 S792Ffs*4 unknown
FGFR2 S799A no effect - predicted
FGFR2 T319I unknown
FGFR2 T319I PIK3CA N345K PIK3CA E453K
FGFR2 T341P gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 T370R unknown
FGFR2 T370_A371delinsC unknown
FGFR2 T370_A371delinsS unknown
FGFR2 T394A no effect - predicted
FGFR2 T730S no effect
FGFR2 T764fs unknown
FGFR2 T786K unknown
FGFR2 V248D unknown
FGFR2 V392A gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V392M no effect - predicted
FGFR2 V395D no effect - predicted
FGFR2 V514L unknown
FGFR2 V563L gain of function - predicted
FGFR2 V564F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564M unknown
FGFR2 V564T no effect - predicted
FGFR2 V565F gain of function - predicted
FGFR2 V565I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V565L gain of function - predicted
FGFR2 V755I no effect
FGFR2 V77M unknown
FGFR2 V797* unknown
FGFR2 W290* loss of function - predicted
FGFR2 W290C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W290_I291delinsC gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W72C unknown
FGFR2 wild-type no effect
FGFR2 Y281C unknown
FGFR2 Y328N gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 Y340C unknown
FGFR2 Y340H unknown
FGFR2 Y375C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 Y376C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 Y588D unknown
FGFR2 Y769* gain of function - predicted
FGFR2 Y779C unknown
FGFR2 Y812* unknown