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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
PIK3CA R88Q GDC-0980 malignant pleural mesothelioma sensitive detail...
ALK rearrange CT-707 malignant pleural mesothelioma no benefit detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00996385 Phase II Bortezomib + Oxaliplatin Velcade and Eloxatin for Patients With Malignant Pleural or Peritoneal Mesothelioma Unknown status USA 0
NCT01064648 Phase Ib/II Cediranib + Cisplatin + Pemetrexed Disodium Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma Active, not recruiting USA 0
NCT01265433 Phase II Montanide ISA 51 + Sargramostim Montanide ISA 51 + Sargramostim + WT1 vaccine WT-1 Analog Peptide Vaccine in Malignant Pleural Mesothelioma After Combined Modality Therapy Completed USA 0
NCT01769547 Phase II Dovitinib A Phase II Study of Single-agent DOVitinib in Advanced Malignant PlEural Mesothelioma Which Has Progressed Following Prior Platinum-Antifolate Chemotherapy Terminated CAN 0
NCT01868022 Phase I Docetaxel Cisplatin + Pemetrexed Disodium GSK3052230 Carboplatin + Paclitaxel Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling Completed USA 6
NCT01870609 Phase II Defactinib Placebo Controlled Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma Terminated USA | CAN 13
NCT01907100 Phase III Cisplatin + Pemetrexed Disodium Nintedanib Nintedanib (BIBF 1120) in Mesothelioma Terminated USA | CAN 25
NCT02004028 Phase II Defactinib Window of Opportunity Study of VS-6063 (Defactinib) in Participants With Surgical Resectable Malignant Pleural Mesothelioma. Terminated USA 0
NCT02399371 Phase II Pembrolizumab Pembrolizumab in Treating Patients With Malignant Mesothelioma Active, not recruiting USA 0
NCT02414269 Phase I Cyclophosphamide + iCasp9M28z T cells iCasp9M28z T cells Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin Active, not recruiting USA 0
NCT02568449 Phase II Nintedanib Nintedanib in Treating Patients With Malignant Pleural Mesothelioma That Is Recurrent Completed USA 0
NCT02592551 Phase II Durvalumab + Tremelimumab Durvalumab MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma Active, not recruiting USA 0
NCT02639091 Phase I Anetumab ravtansine + Cisplatin + Pemetrexed Disodium Phase Ib Study of Anetumab Ravtansine in Combination With Pemetrexed and Cisplatin in Mesothelin-expressing Solid Tumors Completed USA 1
NCT02707666 Phase I Pembrolizumab Cisplatin + Pemetrexed Disodium A Pilot Window-Of-Opportunity Study of the Anti-PD-1 Antibody Pembrolizumab in Patients With Resectable Malignant Pleural Mesothelioma Recruiting USA 0
NCT02709512 Phase II Cisplatin + Pemetrexed Disodium ADI-PEG 20 + Cisplatin + Pemetrexed Disodium Ph 2/3 Study in Subjects With MPM to Assess ADI-PEG 20 With Pemetrexed and Cisplatin (ATOMIC) Recruiting USA 4
NCT02723955 Phase I GSK3359609 GSK3359609 + Pembrolizumab Dose Escalation and Expansion Study of GSK3359609 in Subjects With Selected Advanced Solid Tumors (INDUCE-1) Active, not recruiting USA | CAN 7
NCT02784171 Phase II Cisplatin + Pemetrexed Disodium Pembrolizumab Pembrolizumab in Patients With Advanced Malignant Pleural Mesothelioma Active, not recruiting CAN 2
NCT02824042 Phase I Anetumab ravtansine + Itraconazole Anetumab ravtansine Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole Completed USA 5
NCT02863055 Phase II Nintedanib Nintedanib as Switch Maintenance Treatment of Pleural Malignant Mesothelioma (NEMO) Unknown status 3
NCT02899195 Phase II Cisplatin + Durvalumab + Pemetrexed Disodium Durvalumab Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma (PrE0505) Active, not recruiting USA 0
NCT02899299 Phase III Carboplatin + Cisplatin + Pemetrexed Disodium Ipilimumab + Nivolumab Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients (CheckMate743) Active, not recruiting USA 20
NCT02959463 Phase I Pembrolizumab Adjuvant Pembrolizumab After Radiation Therapy for Lung-Intact Malignant Pleural Mesothelioma Unknown status USA 0
NCT03023319 Phase I Bosutinib + Pemetrexed Disodium Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors Recruiting USA 0
NCT03074513 Phase II Atezolizumab + Bevacizumab Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors Active, not recruiting USA 0
NCT03075527 Phase II Durvalumab + Tremelimumab A Phase 2 Study of Durvalumab in Combination With Tremelimumab in Malignant Pleural Mesothelioma Suspended USA 0
NCT03126630 Phase Ib/II Pembrolizumab Anetumab ravtansine + Pembrolizumab Pembrolizumab With or Without Anetumab Ravtansine in Treating Patients With Mesothelin-Positive Pleural Mesothelioma Recruiting USA | CAN 0
NCT03175172 Phase II CRS-207 + Pembrolizumab Evaluation of CRS-207 With Pembrolizumab in Previously Treated MPM Terminated USA 0
NCT03212404 Phase I Cosibelimab Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers Recruiting 9
NCT03228537 Phase I Atezolizumab + Cisplatin + Pemetrexed Disodium Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma Active, not recruiting USA 0
NCT03319537 Phase Ib/II MLN4924 Cisplatin + MLN4924 + Pemetrexed Disodium Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma Active, not recruiting USA 0
NCT03399552 Phase Ib/II Avelumab Stereotactic Body Radiation Therapy and Avelumab Immunotherapy for Treatment of Malignant Mesothelioma Active, not recruiting USA 0
NCT03546426 Phase I Aldesleukin + Pembrolizumab Pembrolizumab Plus Autologous Dendritic Cell Vaccine in Patients With PD-L1 Negative Advanced Mesothelioma Who Have Failed Prior Therapies (MESOVAX) Recruiting 1
NCT03644550 Phase II LMB-100 + Pembrolizumab Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma Terminated USA 0
NCT03710876 Phase III Celecoxib + Gemcitabine Celecoxib + Gemcitabine + rAd-IFN Efficacy & Safety of rAd-IFN Administered With Celecoxib & Gemcitabine in Patients With Malignant Pleural Mesothelioma (INFINITE) Active, not recruiting USA | CAN 7
NCT03715933 Phase I INBRX-109 Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas Recruiting USA 0
NCT03717415 Phase Ib/II Carboplatin + Rebastinib A Study of Rebastinib (DCC-2036) in Combination With Carboplatin in Patients With Advanced or Metastatic Solid Tumors Active, not recruiting USA 0
NCT03760575 Phase I Cisplatin + Pembrolizumab + Pemetrexed Disodium Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM) Not yet recruiting USA 0
NCT03762018 Phase III Bevacizumab + Carboplatin + Pemetrexed Disodium Atezolizumab + Bevacizumab + Carboplatin + Pemetrexed Disodium BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma (BEAT-meso) Recruiting 6
NCT03918252 Phase II Ipilimumab + Nivolumab Nivolumab Neoadjuvant Immune Checkpoint Blockade in Resectable Malignant Pleural Mesothelioma Recruiting USA 0
NCT03920839 Phase I Carboplatin + Paclitaxel + Retifanlimab Cisplatin + Gemcitabine + Retifanlimab Cisplatin + Pemetrexed Disodium + Retifanlimab Carboplatin + Pemetrexed Disodium + Retifanlimab INCMGA00012 Plus Chemotherapy in Participants With Advanced Solid Tumors (POD1UM-105) Withdrawn 0
NCT04013334 Phase II MTG201 + Nivolumab MTG201 Plus Nivolumab in Patients With Relapsed Pleural Mesothelioma Unknown status USA 0
NCT04040231 Phase I Galinpepimut-S + Nivolumab + Sargramostim Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma Recruiting USA 0
NCT04042480 Phase I SGN-CD228A A Study of SGN-CD228A in Advanced Solid Tumors Recruiting USA 4
NCT04162015 Phase I Cisplatin + Nivolumab + Pemetrexed Disodium Carboplatin + Nivolumab + Pemetrexed Disodium A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma Recruiting USA 0
NCT04177953 Phase II Carboplatin + Pemetrexed Disodium Cisplatin + Nivolumab + Pemetrexed Disodium Cisplatin + Pemetrexed Disodium Carboplatin + Nivolumab + Pemetrexed Disodium Nivolumab With Chemotherapy in Pleural Mesothelioma After Surgery Recruiting 1
NCT04201145 Phase I Pembrolizumab Defactinib + Pembrolizumab Pembrolizumab + Defactinib In Pleural Mesothelioma Withdrawn USA 0
NCT04300244 Phase II Ipilimumab + Nivolumab + UV1 Telomerase peptide vaccine Ipilimumab + Nivolumab Nivolumab and Ipilimumab +/- UV1 Vaccination as Second Line Treatment in Patients With Malignant Mesothelioma (NIPU) Recruiting 5
NCT04334759 Phase III Durvalumab Cisplatin + Pemetrexed Disodium Cisplatin + Durvalumab + Pemetrexed Disodium DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma (DREAM3R) Recruiting USA 2
NCT04491942 Phase I BAY1895344 + Cisplatin BAY1895344 + Cisplatin + Gemcitabine Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer Recruiting USA 0
NCT04525859 Phase I Poly ICLC Poly-ICLC (Hiltonol) Vaccine In Malignant Pleural Mesothelioma Recruiting USA 0
NCT04665206 Phase I VT3989 Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors Enriched for Tumors With NF2 Gene Mutations Recruiting USA 1
NCT04672434 Phase I Sym021 + Sym024 Sym024 Sym024 Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies Recruiting USA | CAN 0
NCT04840615 Phase I Ipilimumab + LMB-100 Phase I Study of Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma Recruiting USA 0
NCT04857372 Phase I IAG933 A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors Recruiting 3
NCT04897022 Phase I Pembrolizumab A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma Recruiting USA 0
NCT04914897 Phase II Carboplatin + Pembrolizumab + Pemetrexed Disodium + THOR-707 Pembrolizumab + THOR-707 Nab-paclitaxel + Pembrolizumab + THOR-707 Cisplatin + Pembrolizumab + Pemetrexed Disodium + THOR-707 A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Lung Cancer or Mesothelioma Recruiting USA 8
NCT04940637 Phase II Dostarlimab-gxly + Niraparib UNITO-001-A Phase II Study Niraparib Plus Dostarlimab in HRR/PDL1 Positive MPM/NSCLC (UNITO-001) Recruiting 1
NCT04958239 Phase I BI 754091 + BI 765179 BI 765179 A Study to Test Different Doses of BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) Recruiting USA 2
NCT04996017 Phase III Atezolizumab Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso) (AtezoMeso) Recruiting 1
NCT05005429 Phase II M7824 Study of the Efficacy and Safety of the Bintrafusp Alfa in Previously Treated Advanced Malignant Pleural Mesothelioma (BIMES) Recruiting 1
NCT05071014 Phase I Pembrolizumab A Study of Pembrolizumab and Cryoablation in People With Mesothelioma Recruiting USA 0