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ID DOID:8850
Name salivary gland cancer
Definition An oral cavity cancer that is located_in the salivary gland.
Source DiseaseOntology.org
Alt Ids DOID:9148 DOID:8873
Path disease disease of cellular proliferation cancer organ system cancer gastrointestinal system cancer oral cavity cancer salivary gland cancer

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
NTRK1 fusion Entrectinib salivary gland cancer sensitive detail...
NTRK2 fusion Entrectinib salivary gland cancer sensitive detail...
NTRK2 fusion Larotrectinib salivary gland cancer sensitive detail...
NTRK1 fusion Larotrectinib salivary gland cancer sensitive detail...
BRAF V600E Vemurafenib salivary gland cancer predicted - sensitive detail...
HRAS mutant Tipifarnib salivary gland cancer predicted - sensitive detail...
RET fusion Selpercatinib salivary gland cancer sensitive detail...
BRAF V600E Dabrafenib + Trametinib salivary gland cancer sensitive detail...
EML4 - ALK Alectinib salivary gland cancer predicted - sensitive detail...
FGFR2 Y375C Erdafitinib salivary gland cancer predicted - sensitive detail...
FGFR2 W72C FGFR2 E565A Erdafitinib salivary gland cancer predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01316757 Phase II Carboplatin + Cetuximab + Erlotinib + Paclitaxel Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer Completed USA 0
NCT01969578 Phase II Bicalutamide + Triptorelin Carboplatin + Paclitaxel Cisplatin + Doxorubicin Androgen Deprivation Therapy in Advanced Salivary Gland Cancer Active, not recruiting NLD | ITA | FRA | DEU | BEL | AUT 2
NCT02091141 Phase II Erlotinib Alectinib Cobimetinib + Vemurafenib Pertuzumab + Trastuzumab Vismodegib Atezolizumab My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors Completed USA 0
NCT02538510 Phase Ib/II Pembrolizumab + Vorinostat Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer and Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery Completed USA 0
NCT02576431 Phase II Larotrectinib A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE) Active, not recruiting USA | FRA | ESP | DEU 14
NCT02628067 Phase II Pembrolizumab Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) Recruiting USA | NLD | ITA | FRA | ESP | DEU | CAN | AUS 15
NCT02636036 Phase I Enadenotucirev + Pembrolizumab Study of Enadenotucirev and Pembrolizumab in Subjects With Metastatic or Advanced Epithelial Tumors Completed USA 0
NCT02749903 Phase II Enzalutamide Enzalutamide for Patients With Androgen Receptor Positive Salivary Cancers Unknown status USA 0
NCT02795156 Phase II Cabozantinib Afatinib Regorafenib Study Assessing Activity of Molecularly Matched Targeted Therapies in Select Tumor Types Based on Genomic Alterations Completed USA 0
NCT03172624 Phase II Ipilimumab + Nivolumab Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer Active, not recruiting USA 0
NCT03319628 Phase I XMT-1536 First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b Active, not recruiting USA 0
NCT03360890 Phase II Docetaxel + Pembrolizumab Synergy of Pembrolizumab Anti-PD-1 Immunotherapy With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors Recruiting USA 0
NCT03781986 Phase Ib/II APG-115 APG-115 in Salivary Gland Cancer Trial Active, not recruiting USA 0
NCT03936959 Phase I LY3434172 A Study of LY3434172, a PD-1 and PD-L1 Bispecific Antibody, in Advanced Cancer Completed USA | FRA | BEL | AUS 1
NCT04105543 Phase I CLR 131 CLR 131 Combined With Radiation for Head and Neck Cancer Active, not recruiting USA 0
NCT04209660 Phase II Lenvatinib + Pembrolizumab Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers Recruiting USA 0
NCT04682431 Phase I Pembrolizumab + PY159 PY159 A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors Terminated USA 0
NCT04704661 Phase I Ceralasertib + Trastuzumab deruxtecan Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial Recruiting USA 0
NCT04895735 Phase II Pembrolizumab + Pemetrexed Disodium Pemetrexed and Pembrolizumab for the Treatment of Recurrent and/or Metastatic Salivary Gland Cancer Recruiting USA 0
NCT05408845 Phase II Docetaxel + Trastuzumab Ado-trastuzumab emtansine Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) for Recurrent, Metastatic, or Unresectable HER2-Positive Salivary Gland Cancer Recruiting USA 0
NCT05608876 Phase II Tigilanol tiglate A Clinical Study to Investigate the Efficacy of Tigilanol Tiglate Directly in Head and Neck Cancer Recruiting GBR | AUS 0
NCT05669664 Phase II Darolutamide + Leuprolide Testing the Anti-Cancer Drug Darolutamide in Patients With Testosterone-driven Salivary Gland Cancers Recruiting USA 0
NCT05884320 Phase II Sacituzumab govitecan-hziy Phase II Trial of Sacituzumab Govitecan in Recurrent and/or Metastatic Salivary Gland Cancers Recruiting USA 0