Disease Detail


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ID DOID:3078
Name anaplastic astrocytoma
Definition A malignant astrocytoma that is characterized by cells with regular, round to oval nuclei.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer cell type cancer high grade glioma malignant astrocytoma anaplastic astrocytoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
IDH1 R132H Azacitidine anaplastic astrocytoma sensitive detail...
IDH1 mutant N/A anaplastic astrocytoma not applicable detail...
IDH2 mutant N/A anaplastic astrocytoma not applicable detail...
BRAF V600E Dabrafenib + Trametinib anaplastic astrocytoma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib anaplastic astrocytoma sensitive detail...
BRAF V600E Vemurafenib anaplastic astrocytoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02052778 Phase Ib/II Futibatinib A Study of TAS-120 in Patients With Advanced Solid Tumors Completed USA | CAN 12
NCT02800486 Phase II Cetuximab Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA Recruiting USA 0
NCT03128047 Phase I Bevacizumab + Temozolomide HUMC 1612: Optune NovoTTF-200A System Recruiting USA 0
NCT03224104 Phase I Radiotherapy + Zotiraciclib Temozolomide + Zotiraciclib Zotiraciclib Study of TG02 in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma (STEAM) Active, not recruiting 5
NCT03581292 Phase II Temozolomide + Veliparib Veliparib Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations Active, not recruiting USA | CAN 3
NCT03657576 Phase I C134-HSV-1 Trial of C134 in Patients With Recurrent GBM (C134-HSV-1) Recruiting USA 0
NCT03893487 Phase I CUDC-907 Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016) Recruiting USA 1
NCT03911388 Phase I HSV-1 G207 HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors Recruiting USA 0
NCT04047303 Phase I CC-90010 CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma Active, not recruiting USA 1
NCT04254419 Phase I Intra-tumoral Injection of Natural Killer Cells in High-Grade Gliomas Not yet recruiting USA 0
NCT04295759 Phase I INCB7839 INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas Recruiting USA 0
NCT04482933 Phase II HSV-1 G207 HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Not yet recruiting USA 0
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04655404 Phase I Larotrectinib A Pilot Study of Larotectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion (CONNECT1903) Recruiting USA | CAN 4
NCT04691960 Phase II Metformin A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging Recruiting USA 0
NCT04704154 Phase II Nivolumab + Regorafenib A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors Recruiting USA 7
NCT04809805 Phase I BAY2666605 A Study to Learn How Safe BAY2666605 is, How it Affects the Body, How it Moves Into, Through and Out of the Body, the Maximum Amount That Can be Given and Its Action Against Tumors in Adult Participants With Skin Cancer That Has Spread to Other Parts of the Body and Other Types of Advanced Cancer Recruiting USA 0
NCT05099003 Phase Ib/II Selinexor A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma and H3 K27M-Mutant High-Grade Glioma Not yet recruiting USA 0