Disease Detail


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ID DOID:3078
Name anaplastic astrocytoma
Definition A malignant astrocytoma that is characterized by cells with regular, round to oval nuclei.
Source DiseaseOntology.org
Alt Ids
Path disease disease of cellular proliferation cancer cell type cancer high grade glioma malignant astrocytoma anaplastic astrocytoma


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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
IDH1 R132H Azacitidine anaplastic astrocytoma sensitive detail...
IDH1 mutant N/A anaplastic astrocytoma not applicable detail...
IDH2 mutant N/A anaplastic astrocytoma not applicable detail...
BRAF V600E Dabrafenib + Trametinib anaplastic astrocytoma sensitive detail...
BRAF V600E Cobimetinib + Vemurafenib anaplastic astrocytoma sensitive detail...
BRAF V600E Vemurafenib anaplastic astrocytoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02052778 Phase Ib/II Futibatinib A Study of TAS-120 in Patients With Advanced Solid Tumors Completed USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | AUS 4
NCT02062827 Phase I M032 Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma (M032-HSV-1) Active, not recruiting USA 0
NCT02800486 Phase II Cetuximab Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA Recruiting USA 0
NCT03128047 Phase I Bevacizumab + Temozolomide HUMC 1612: Optune NovoTTF-200A System Active, not recruiting USA 0
NCT03224104 Phase I Radiotherapy + Zotiraciclib Temozolomide + Zotiraciclib Zotiraciclib Study of TG02 in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma (STEAM) Completed NLD | FRA | DEU | AUT 1
NCT03581292 Phase II Temozolomide + Veliparib Veliparib Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations Active, not recruiting USA | NZL | CAN | AUS 1
NCT03657576 Phase I C134-HSV-1 Trial of C134 in Patients With Recurrent GBM (C134-HSV-1) Recruiting USA 0
NCT03893487 Phase I CUDC-907 Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016) Active, not recruiting USA 1
NCT03911388 Phase I HSV-1 G207 HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors Active, not recruiting USA 0
NCT04047303 Phase I CC-90010 CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma Active, not recruiting USA | ESP 0
NCT04254419 Phase I Intra-tumoral Injection of Natural Killer Cells in High-Grade Gliomas Not yet recruiting USA 0
NCT04295759 Phase I INCB7839 INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas Active, not recruiting USA 0
NCT04482933 Phase II HSV-1 G207 HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma Not yet recruiting USA 0
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04655404 Phase I Larotrectinib A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion Recruiting USA | DEU | CAN | AUS 0
NCT04691960 Phase II Metformin A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging Recruiting USA 0
NCT04704154 Phase II Nivolumab + Regorafenib A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors Active, not recruiting USA | ITA | GBR | FRA | BEL 3
NCT04809805 Phase I BAY2666605 A Study to Learn How Safe BAY2666605 is, How it Affects the Body, How it Moves Into, Through and Out of the Body, the Maximum Amount That Can be Given and Its Action Against Tumors in Adult Participants With Skin Cancer That Has Spread to Other Parts of the Body and Other Types of Advanced Cancer Terminated USA 0
NCT04978727 Phase I SurVaxM A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma Recruiting USA | CAN 0
NCT05084430 Phase Ib/II M032 + Pembrolizumab Study of Pembrolizumab and M032 (NSC 733972) Recruiting USA 0
NCT05099003 Phase Ib/II Selinexor A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) Recruiting USA | NZL | CAN | AUS 0
NCT05429502 Phase Ib/II Ribociclib + Temozolomide + Topotecan Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors Recruiting USA | ITA | FRA | ESP | DEU | AUS 1
NCT05503797 Phase II Cobicistat + PLX8394 PLX8394 A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations Recruiting USA | ITA | GBR | FRA | ESP | DEU | CAN 2
NCT05686798 Phase I Ad5-yCD/mutTK(SR39)rep-ADP Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma. Recruiting USA 0
NCT05698524 Phase I Abexinostat + Temozolomide A Study of Temodar With PCI-24781 for Patients With Recurrent Glioma Recruiting USA 0
NCT05887882 Phase I TGF-beta-imprinted NK cells Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Brain Tumors (PNOC028) Not yet recruiting USA 0
NCT05956821 Phase Ib/II Bevacizumab + Cetuximab Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age Recruiting USA 0
NCT06011109 Phase Ib/II Bevacizumab APG-157 Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab Recruiting USA 0
NCT06193174 Phase I C134-HSV-1 Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) Not yet recruiting USA 0
NCT06333899 Phase I Lorlatinib Cisplatin + Cyclophosphamide + Lorlatinib + Vincristine Sulfate Carboplatin + Cyclophosphamide + Etoposide + Lorlatinib + Methotrexate + Vincristine Sulfate Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion Not yet recruiting USA | NLD | DEU | CAN | AUS 0
NCT06413706 Phase II Abemaciclib + Temozolomide Temozolomide A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy Not yet recruiting 0