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ID | DOID:3078 |
Name | anaplastic astrocytoma |
Definition | A malignant astrocytoma that is characterized by cells with regular, round to oval nuclei. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer cell type cancer high grade glioma malignant astrocytoma anaplastic astrocytoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
IDH1 R132H | Azacitidine | anaplastic astrocytoma | sensitive | detail... |
IDH1 mutant | N/A | anaplastic astrocytoma | not applicable | detail... |
IDH2 mutant | N/A | anaplastic astrocytoma | not applicable | detail... |
BRAF V600E | Dabrafenib + Trametinib | anaplastic astrocytoma | sensitive | detail... |
BRAF V600E | Cobimetinib + Vemurafenib | anaplastic astrocytoma | sensitive | detail... |
BRAF V600E | Vemurafenib | anaplastic astrocytoma | predicted - sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT02052778 | Phase Ib/II | Futibatinib | A Study of TAS-120 in Patients With Advanced Solid Tumors | Active, not recruiting | USA | ITA | FRA | ESP | DEU | CAN | 7 |
NCT02062827 | Phase I | M032 | Genetically Engineered HSV-1 Phase 1 Study for the Treatment of Recurrent Malignant Glioma (M032-HSV-1) | Active, not recruiting | USA | 0 |
NCT02800486 | Phase II | Cetuximab | Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA | Recruiting | USA | 0 |
NCT03128047 | Phase I | Bevacizumab + Temozolomide | HUMC 1612: Optune NovoTTF-200A System | Recruiting | USA | 0 |
NCT03224104 | Phase I | Radiotherapy + Zotiraciclib Temozolomide + Zotiraciclib Zotiraciclib | Study of TG02 in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma (STEAM) | Completed | FRA | DEU | AUT | 2 |
NCT03581292 | Phase II | Temozolomide + Veliparib Veliparib | Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations | Active, not recruiting | USA | CAN | 3 |
NCT03657576 | Phase I | C134-HSV-1 | Trial of C134 in Patients With Recurrent GBM (C134-HSV-1) | Recruiting | USA | 0 |
NCT03893487 | Phase I | CUDC-907 | Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016) | Active, not recruiting | USA | 1 |
NCT03911388 | Phase I | HSV-1 G207 | HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors | Recruiting | USA | 0 |
NCT04047303 | Phase I | CC-90010 | CNS Penetration, PK and PD of Preoperative CC-90010 in Progressive/Recurrent Diffuse Astrocytoma, Anaplastic Astrocytoma and Glioblastoma | Active, not recruiting | USA | ESP | 0 |
NCT04254419 | Phase I | Intra-tumoral Injection of Natural Killer Cells in High-Grade Gliomas | Not yet recruiting | USA | 0 | |
NCT04295759 | Phase I | INCB7839 | INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas | Active, not recruiting | USA | 0 |
NCT04482933 | Phase II | HSV-1 G207 | HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma | Not yet recruiting | USA | 0 |
NCT04541082 | Phase I | ONC206 | Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms | Recruiting | USA | 0 |
NCT04655404 | Phase I | Larotrectinib | A Pilot Study of Larotectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion (CONNECT1903) | Recruiting | USA | DEU | CAN | 3 |
NCT04691960 | Phase II | Metformin | A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging | Recruiting | USA | 0 |
NCT04704154 | Phase II | Nivolumab + Regorafenib | A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors | Active, not recruiting | USA | ITA | FRA | BEL | 4 |
NCT04809805 | Phase I | BAY2666605 | A Study to Learn How Safe BAY2666605 is, How it Affects the Body, How it Moves Into, Through and Out of the Body, the Maximum Amount That Can be Given and Its Action Against Tumors in Adult Participants With Skin Cancer That Has Spread to Other Parts of the Body and Other Types of Advanced Cancer | Completed | USA | 0 |
NCT04978727 | Phase I | SurVaxM | A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma | Recruiting | USA | 0 |
NCT05084430 | Phase Ib/II | M032 + Pembrolizumab | Study of Pembrolizumab and M032 (NSC 733972) | Recruiting | USA | 0 |
NCT05099003 | Phase Ib/II | Selinexor | A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) | Recruiting | USA | CAN | 0 |
NCT05429502 | Phase Ib/II | Ribociclib + Temozolomide + Topotecan | Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors | Recruiting | USA | FRA | ESP | DEU | 1 |