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Gene Symbol  ATM  
Synonyms  AT1  ATA  ATC  ATD  ATDC  ATE  TEL1  TELO1  
Gene Description  ATM, ATM serine/threonine kinase, is a member of the serinethreonine kinase family and coordinates cellular responses to DNA damage through activation of distinct DNA repair and signaling pathways (PMID: 22079189). ATM germline mutations are associated with ataxia telangiectasia (PMID: 27283171) and ATM somatic mutations are commonly observed in endometrial, colon, pancreatic, breast cancers (PMID: 27283171, PMID: 27413114) and urothelial cancer (PMID: 29682192).  

Molecular Profile  Protein Effect  Treatment Approaches 

ATM A1127V  unknown  
ATM A1309T  unknown  
ATM A1505V  unknown  
ATM A1742P  loss of function  predicted  Olaparib 
ATM A1812P  unknown  
ATM A1950T  unknown  
ATM A2062V  loss of function  predicted  Olaparib 
ATM A2067D  loss of function  Olaparib 
ATM A220V  no effect  predicted  
ATM A2274T  no effect  predicted  
ATM A2308T  unknown  
ATM A2420G  unknown  
ATM A2524P  unknown  
ATM A2602fs  loss of function  predicted  Olaparib 
ATM A2622T  unknown  
ATM A2843V  unknown  
ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V  
ATM A3006T  unknown  
ATM A302fs  loss of function  Olaparib 
ATM A59S  loss of function  predicted  Olaparib 
ATM amp  no effect  
ATM C2464R  no effect  predicted  
ATM C2488Y  loss of function  predicted  Olaparib 
ATM C353fs  loss of function  predicted  Olaparib 
ATM C430S  unknown  
ATM C532Y  unknown  
ATM C540*  loss of function  predicted  Olaparib 
ATM C730Y  unknown  
ATM D126E  unknown  
ATM D1285G  unknown  
ATM D1682H  loss of function  predicted  Olaparib 
ATM D1682Y  loss of function  predicted  Olaparib 
ATM D1853N  no effect  predicted  
ATM D1853V  no effect  predicted  
ATM D1963N  unknown  
ATM D2320N  unknown  
ATM D2395V  unknown  
ATM D2448A  unknown  
ATM D2448G  unknown  
ATM D2625_A2626delinsEP  unknown  
ATM D2708N  loss of function  Olaparib 
ATM D2720H  unknown  
ATM D2720N  unknown  
ATM D2721N  unknown  
ATM D2721Y  unknown  
ATM D2725G  unknown  
ATM D2725V  unknown  
ATM D2870Y  unknown  
ATM D351Y  unknown  
ATM D639G  unknown  
ATM D983N  unknown  
ATM dec exp  no effect  Olaparib 
ATM dec exp ATM inact mut  
ATM del  loss of function  Olaparib 
ATM del ATR dec exp  
ATM E1072*  loss of function  predicted  Olaparib 
ATM E1666*  loss of function  predicted  Olaparib 
ATM E1959K  unknown  
ATM E1978*  loss of function  predicted  Olaparib 
ATM E2039*  loss of function  predicted  Olaparib 
ATM E2039K  loss of function  predicted  Olaparib 
ATM E2164G  unknown  
ATM E2187*  loss of function  Olaparib 
ATM E2272*  loss of function  predicted  Olaparib 
ATM E2294G  unknown  
ATM E2304Gfs*69  loss of function  predicted  Olaparib 
ATM E2668G  no effect  predicted  
ATM E277*  loss of function  predicted  Olaparib 
ATM E2904K  unknown  
ATM E2977Rfs*2  loss of function  predicted  Olaparib 
ATM I1294Nfs*8 ATM E2977Rfs*2  
ATM E343*  loss of function  predicted  Olaparib 
ATM E390*  loss of function  predicted  Olaparib 
ATM E473*  loss of function  predicted  Olaparib 
ATM E473* ATM loss  
ATM E518fs  loss of function  predicted  Olaparib 
ATM E522*  loss of function  predicted  Olaparib 
ATM E668*  loss of function  predicted  Olaparib 
ATM E848Q  unknown  
ATM E871K  unknown  
ATM F1025L  loss of function  predicted  Olaparib 
ATM F1683V  unknown  
ATM F168L  unknown  
ATM F2140V  unknown  
ATM F2516C  unknown  
ATM F2571Yfs*4  loss of function  predicted  Olaparib 
ATM F2732V  loss of function  predicted  Olaparib 
ATM F2827C  loss of function  Olaparib 
ATM F2839L  unknown  
ATM F570L  unknown  
ATM F582L  unknown  
ATM F858L  no effect  predicted  
ATM F897I  unknown  
ATM G1459R  unknown  
ATM G2023R  unknown  
ATM G2083*  loss of function  predicted  Olaparib 
ATM G2287A  no effect  predicted  
ATM G2694R  unknown  
ATM G2695A  unknown  
ATM G2695C  unknown  
ATM G2695S  unknown  
ATM G2718_K2756del  loss of function  Olaparib 
ATM G2765S  loss of function  Olaparib 
ATM G2772R  no effect  predicted  
ATM G2867R  loss of function  Olaparib 
ATM G2891D  unknown  
ATM G2891R  unknown  
ATM G514D  unknown  
ATM H1380Y  loss of function  predicted  Olaparib 
ATM H1436Y  unknown  
ATM H2038D  unknown  
ATM H2038R  unknown  
ATM H2038Y  loss of function  predicted  Olaparib 
ATM H2554D  loss of function  Olaparib 
ATM H2872Q  unknown  
ATM H2872R  unknown  
ATM I10fs  loss of function  predicted  Olaparib 
ATM I124V  unknown  
ATM I1294Nfs*8  loss of function  predicted  Olaparib 
ATM I1441fs  loss of function  predicted  Olaparib 
ATM Q1331H ATM I1441fs  
ATM I1453fs  loss of function  predicted  Olaparib 
ATM I1581Nfs*5  loss of function  predicted  Olaparib 
ATM I1681V  loss of function  Olaparib 
ATM I1849fs  loss of function  predicted  Olaparib 
ATM I2629fs  loss of function  predicted  Olaparib 
ATM I2629fs ATM neg  
ATM I2701Nfs*17  loss of function  predicted  Olaparib 
ATM I2888L  unknown  
ATM I2888M  unknown  
ATM I2888T  unknown  
ATM I323V  unknown  
ATM inact mut  loss of function  Olaparib 
ATM LOH ATM inact mut  
ATM inact mut ATM loss  
ATM K1410*  loss of function  predicted  Olaparib 
ATM K1773N  unknown  
ATM K1807E  loss of function  Olaparib 
ATM K1964E  unknown  
ATM K1992T  no effect  predicted  
ATM K224E  unknown  
ATM K2749I  loss of function  predicted  Olaparib 
ATM K2756*  loss of function  predicted  Olaparib 
ATM K2811fs  loss of function  predicted  Olaparib 
ATM K293*  loss of function  Olaparib 
ATM K3018Q  unknown  
ATM K3043R  unknown  
ATM K468Efs*18  loss of function  predicted  Olaparib 
ATM K468fs  loss of function  predicted  Olaparib 
ATM L100W  unknown  
ATM L1046R  unknown  
ATM L1239fs  loss of function  predicted  Olaparib 
ATM L1322I  no effect  predicted  
ATM L1408F  unknown  
ATM L1408I  unknown  
ATM L1420F  no effect  predicted  
ATM L1439I  unknown  
ATM L1449*  loss of function  predicted  Olaparib 
ATM L1465P  loss of function  Olaparib 
ATM L15fs  loss of function  predicted  Olaparib 
ATM L1675F  unknown  
ATM L1874F  loss of function  predicted  Olaparib 
ATM L1939V  unknown  
ATM L1956H  loss of function  predicted  Olaparib 
ATM L2077I  unknown  
ATM L2307F  loss of function  
ATM L2332P  unknown  
ATM L2338P  loss of function  Olaparib 
ATM L2427P  loss of function  Olaparib 
ATM L2427_R2428del  loss of function  Olaparib 
ATM L2452P  loss of function  Olaparib 
ATM L2492R  unknown  
ATM L2561M  unknown  
ATM L2572fs  loss of function  predicted  Olaparib 
ATM L259I  unknown  
ATM L2722M  unknown  
ATM L2738*  loss of function  predicted  Olaparib 
ATM L2780R  unknown  
ATM L2877F  unknown  
ATM L2890I  unknown  
ATM L2890P  unknown  
ATM L2890R  unknown  
ATM L2890V  loss of function  predicted  Olaparib 
ATM L2953Tfs*3  loss of function  predicted  Olaparib 
ATM L2995I  unknown  
ATM L348_M349insYIV  unknown  
ATM L546V  no effect  
ATM L581V  no effect  predicted  
ATM L694R  unknown  
ATM L762Qfs*4  loss of function  predicted  Olaparib 
ATM L804fs  loss of function  predicted  Olaparib 
ATM L804fs ATM S978fs RET M918T  
ATM L822V  unknown  
ATM L942I  unknown  
ATM L991S  unknown  
ATM LOH  unknown  
ATM P1069fs ATM LOH  
ATM loss  loss of function  Olaparib 
ATM S214Pfs*16 ATM loss  
ATM S214Ffs*40 ATM loss  
ATM M1484Rfs*15  loss of function  predicted  Olaparib 
ATM M2405L  unknown  
ATM M2520fs  loss of function  predicted  Olaparib 
ATM M2531T  unknown  
ATM M349K  unknown  
ATM M779I  unknown  
ATM mutant  unknown  
ATM mut NRAS Q61R  
ATM mut CHEK2 mut  
ATM N1356D  unknown  
ATM N1650S  unknown  Olaparib 
ATM N2326_K2363del  loss of function  predicted  Olaparib 
ATM N2603S  unknown  
ATM N2875H  unknown  
ATM N2875K  unknown  
ATM N2875S  unknown  
ATM N2875T  unknown  
ATM N3033*  loss of function  Olaparib 
ATM N358I  unknown  
ATM N765Kfs*12  loss of function  predicted  Olaparib 
ATM N796H  unknown  
ATM N81Tfs*20  loss of function  predicted  Olaparib 
ATM N914S  unknown  
ATM negative  loss of function  Olaparib 
ATM T2333fs ATM neg  
ATM over exp  no effect  
ATM P1054R  no effect  
ATM P1069fs  loss of function  predicted  Olaparib 
ATM P1235L  unknown  
ATM P178S  unknown  
ATM P2353H  unknown  
ATM P2353T  unknown  
ATM P2665T  unknown  
ATM P2699L  loss of function  Olaparib 
ATM P2699S  unknown  Olaparib 
ATM P2842L  unknown  
ATM P292L  loss of function  Olaparib 
ATM P2974L  loss of function  Olaparib 
ATM P604S  loss of function  predicted  Olaparib 
ATM P631S  unknown  
ATM P80S  unknown  
ATM P960H  loss of function  predicted  Olaparib 
ATM positive  unknown  
ATM Q1128R  unknown  
ATM Q1171Tfs*8  loss of function  predicted  Olaparib 
ATM Q1331H  unknown  
ATM Q1537R  unknown  
ATM Q1579fs  loss of function  predicted  Olaparib 
ATM Q1627*  loss of function  predicted  Olaparib 
ATM Q1636Rfs*10  loss of function  predicted  Olaparib 
ATM Q1906*  loss of function  predicted  Olaparib 
ATM Q1919P  unknown  
ATM Q1970*  loss of function  predicted  Olaparib 
ATM Q2066L  unknown  
ATM Q2277*  loss of function  predicted  Olaparib 
ATM Q2297*  loss of function  predicted  Olaparib 
ATM Q2397*  loss of function  predicted  Olaparib 
ATM Q2442P  unknown  
ATM Q2522fs  loss of function  predicted  Olaparib 
ATM Q2729H  unknown  
ATM Q2730P  loss of function  Olaparib 
ATM Q2730R  unknown  
ATM Q2762R  unknown  
ATM Q2800*  loss of function  predicted  Olaparib 
ATM Q2809P  unknown  
ATM Q284*  loss of function  predicted  Olaparib 
ATM Q2972*  loss of function  predicted  Olaparib 
ATM Q3038*  unknown  
ATM Q628Pfs*7  loss of function  predicted  Olaparib 
ATM R1150I  unknown  
ATM R1304*  loss of function  predicted  Olaparib 
ATM R1466*  loss of function  predicted  Olaparib 
ATM R1466P  unknown  
ATM R1466Q  unknown  
ATM R1575H  no effect  
ATM R1618*  loss of function  predicted  Olaparib 
ATM R1730*  loss of function  predicted  Olaparib 
ATM R1730Q  unknown  
ATM R1875*  loss of function  predicted  Olaparib 
ATM R1882*  loss of function  predicted  Olaparib 
ATM R1882* ATM R3008H  
ATM R1898*  loss of function  predicted  Olaparib 
ATM R1918T  unknown  
ATM R2032K  unknown  
ATM R2034*  loss of function  predicted  Olaparib 
ATM R2034P  loss of function  predicted  Olaparib 
ATM R2138Kfs*8  loss of function  predicted  Olaparib 
ATM R221I  unknown  
ATM R23Q  unknown  
ATM R2443P  unknown  
ATM R2443Q  unknown  
ATM R2459C  unknown  
ATM R248Q  unknown  
ATM R250*  loss of function  predicted  Olaparib 
ATM R2506_N2543del  loss of function  Olaparib 
ATM R250Sfs*3  loss of function  predicted  Olaparib 
ATM R2526S  unknown  
ATM R2547_S2549del  loss of function  Olaparib 
ATM R2598*  loss of function  predicted  Olaparib 
ATM R2598Q  unknown  
ATM R2691C  loss of function  predicted  Olaparib 
ATM R2832C  loss of function  Olaparib 
ATM R2832S  unknown  
ATM R2849*  loss of function  predicted  Olaparib 
ATM R2849P  loss of function  Olaparib 
ATM R2854C  unknown  
ATM R2912Efs*26  loss of function  predicted  Olaparib 
ATM R2912G  unknown  
ATM R2993*  loss of function  predicted  Olaparib 
ATM R3008C  loss of function  Olaparib 
ATM R3008H  loss of function  Olaparib 
ATM R3008L  unknown  
ATM R3008X  unknown  
ATM R3047*  loss of function  predicted  Olaparib 
ATM R337C  unknown  
ATM R337H  unknown  
ATM R337S  loss of function  Olaparib 
ATM R337X  unknown  
ATM R45Q  no effect  predicted  
ATM R805*  loss of function  predicted  Olaparib 
ATM R832C  unknown  
ATM S1135_K1192del  unknown  Olaparib 
ATM S131*  loss of function  predicted  Olaparib 
ATM S1403fs  loss of function  predicted  Olaparib 
ATM S1455R  loss of function  Olaparib 
ATM S1455Vfs*3  loss of function  predicted  Olaparib 
ATM S1691R  no effect  
ATM S1905Ifs*25  loss of function  predicted  Olaparib 
ATM S1983N  unknown  
ATM S1993fs  loss of function  predicted  Olaparib 
ATM W1058* ATM S1993fs  
ATM S1993Rfs*23  loss of function  predicted  Olaparib 
ATM S2017fs  loss of function  predicted  Olaparib 
ATM S2017T  unknown  
ATM S214Ffs*40  loss of function  predicted  
ATM S214fs  loss of function  predicted  Olaparib 
ATM S214Pfs*16  loss of function  predicted  Olaparib 
ATM S2190*  loss of function  predicted  
ATM S2394L  loss of function  Olaparib 
ATM S2407*  loss of function  predicted  Olaparib 
ATM S2489F  unknown  
ATM S2592C  loss of function  Olaparib 
ATM S2685T  no effect  
ATM S2707C  no effect  predicted  
ATM S2761Vfs*41  loss of function  predicted  Olaparib 
ATM S2812Vfs*3  loss of function  predicted  Olaparib 
ATM S2812Y  unknown  
ATM S2855_V2856delinsRI  loss of function  Olaparib 
ATM S2859F  unknown  
ATM S2860del  unknown  
ATM S3001N  unknown  
ATM S3027I  unknown  
ATM S333F  loss of function  Olaparib 
ATM S421*  loss of function  predicted  Olaparib 
ATM S49C  unknown  
ATM S707P  unknown  
ATM S719*  loss of function  predicted  Olaparib 
ATM S751*  loss of function  predicted  Olaparib 
ATM S824F  loss of function  predicted  Olaparib 
ATM S978A  unknown  
ATM S978C  unknown  
ATM S978fs  loss of function  predicted  Olaparib 
ATM S978P  unknown  
ATM S99G  unknown  
ATM T1200Lfs*7  loss of function  predicted  Olaparib 
ATM T1200Lfs*7 NRAS Q61K TP53 R213*  
ATM T1350M  unknown  
ATM T1743I  loss of function  Olaparib 
ATM T1756I  unknown  
ATM T1880R  unknown  
ATM T2031I  no effect  predicted  
ATM T2333fs  loss of function  predicted  Olaparib 
ATM T2333Nfs*40  loss of function  predicted  Olaparib 
ATM T2396S  unknown  
ATM T2666A  loss of function  Olaparib 
ATM T2743M  unknown  
ATM T2902fs  loss of function  predicted  Olaparib 
ATM T2934I  unknown  
ATM T2947S  loss of function  predicted  Olaparib 
ATM T593del  unknown  
ATM T86I  unknown  
ATM V1268*  loss of function  predicted  Olaparib 
ATM V1268fs  loss of function  predicted  Olaparib 
ATM V1538fs  loss of function  predicted  Olaparib 
ATM V1570A  unknown  
ATM V1671D  unknown  
ATM V1841I  no effect  predicted  
ATM V1941L  loss of function  Olaparib 
ATM V2119fs  loss of function  predicted  Olaparib 
ATM V2288fs  loss of function  predicted  Olaparib 
ATM V2424G  loss of function  Olaparib 
ATM V2439A  unknown  
ATM V2664del  loss of function  
ATM V2716A  loss of function  Olaparib 
ATM V2727A  unknown  
ATM V2731G  unknown  
ATM V278fs  loss of function  predicted  Olaparib 
ATM V2873I  unknown  
ATM V2951F  unknown  
ATM V410A  unknown  
ATM V519I  loss of function  predicted  Olaparib 
ATM V566Ifs*6  loss of function  predicted  Olaparib 
ATM V60F  unknown  
ATM V630M  unknown  
ATM W1058*  loss of function  predicted  Olaparib 
ATM W2104*  loss of function  predicted  Olaparib 
ATM W2109*  loss of function  predicted  Olaparib 
ATM W2300*  loss of function  predicted  Olaparib 
ATM W2845C  unknown  
ATM W3052C  unknown  
ATM W412*  loss of function  predicted  Olaparib 
ATM W412C  unknown  
ATM W524*  loss of function  predicted  Olaparib 
ATM W57*  loss of function  predicted  Olaparib 
ATM wildtype  no effect  
ATM wildtype TP53 mut  
ATM Y1124F  unknown  
ATM Y1229*  loss of function  predicted  Olaparib 
ATM Y1442*  loss of function  predicted  Olaparib 
ATM Y1961C  loss of function  Olaparib 
ATM Y2019C  loss of function  predicted  Olaparib 
ATM Y2371*  loss of function  predicted  Olaparib 
ATM Y2398C  unknown  
ATM Y2437C  unknown  
ATM Y2437S  unknown  
ATM Y2755C  unknown  
ATM Y2954C  unknown  
ATM Y54*  loss of function  predicted  Olaparib 