Gene Detail

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Gene Symbol ATM
Synonyms AT1 | ATA | ATC | ATD | ATDC | ATE | TEL1 | TELO1
Gene Description ATM, ATM serine/threonine kinase, is a member of the serine-threonine kinase family and coordinates cellular responses to DNA damage through activation of distinct DNA repair and signaling pathways (PMID: 22079189). ATM germline mutations are associated with ataxia telangiectasia (PMID: 27283171) and ATM somatic mutations are commonly observed in endometrial, colon, pancreatic, breast cancers (PMID: 27283171, PMID: 27413114) and urothelial cancer (PMID: 29682192).

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Molecular Profile Protein Effect Treatment Approaches
ATM A1127V unknown
ATM A1309T unknown
ATM A1505V unknown
ATM A1742P loss of function - predicted Olaparib
ATM A1812P unknown
ATM A1950T unknown
ATM A2062V loss of function - predicted Olaparib
ATM A2067D loss of function Olaparib
ATM A220V no effect - predicted
ATM A2274T no effect - predicted
ATM A2308T unknown
ATM A2420G unknown
ATM A2524P unknown
ATM A2602fs loss of function - predicted Olaparib
ATM A2622T unknown
ATM A2843V unknown
ATM Q628Pfs*7 ATM I1581Nfs*5 ATM A2843V
ATM A3006T unknown
ATM A302fs loss of function Olaparib
ATM A59S loss of function - predicted Olaparib
ATM amp no effect
ATM C2464R no effect - predicted
ATM C2488Y loss of function - predicted Olaparib
ATM C353fs loss of function - predicted Olaparib
ATM C430S unknown
ATM C532Y unknown
ATM C540* loss of function - predicted Olaparib
ATM C730Y unknown
ATM D126E unknown
ATM D1285G unknown
ATM D1682H loss of function - predicted Olaparib
ATM D1682Y loss of function - predicted Olaparib
ATM D1853N no effect - predicted
ATM D1853V no effect - predicted
ATM D1963N unknown
ATM D2320N unknown
ATM D2395V unknown
ATM D2448A unknown
ATM D2448G unknown
ATM D2625_A2626delinsEP unknown
ATM D2708N loss of function Olaparib
ATM D2720H unknown
ATM D2720N unknown
ATM D2721N unknown
ATM D2721Y unknown
ATM D2725G unknown
ATM D2725V unknown
ATM D2870Y unknown
ATM D351Y unknown
ATM D639G unknown
ATM D983N unknown
ATM dec exp no effect Olaparib
ATM dec exp ATM inact mut
ATM del loss of function Olaparib
ATM del ATR dec exp
ATM E1072* loss of function - predicted Olaparib
ATM E1666* loss of function - predicted Olaparib
ATM E1959K unknown
ATM E1978* loss of function - predicted Olaparib
ATM E2039* loss of function - predicted Olaparib
ATM E2039K loss of function - predicted Olaparib
ATM E2164G unknown
ATM E2187* loss of function Olaparib
ATM E2272* loss of function - predicted Olaparib
ATM E2294G unknown
ATM E2304Gfs*69 loss of function - predicted Olaparib
ATM E2668G no effect - predicted
ATM E277* loss of function - predicted Olaparib
ATM E2904K unknown
ATM E2977Rfs*2 loss of function - predicted Olaparib
ATM I1294Nfs*8 ATM E2977Rfs*2
ATM E343* loss of function - predicted Olaparib
ATM E390* loss of function - predicted Olaparib
ATM E473* loss of function - predicted Olaparib
ATM E473* ATM loss
ATM E518fs loss of function - predicted Olaparib
ATM E522* loss of function - predicted Olaparib
ATM E668* loss of function - predicted Olaparib
ATM E848Q unknown
ATM E871K unknown
ATM F1025L loss of function - predicted Olaparib
ATM F1683V unknown
ATM F168L unknown
ATM F2140V unknown
ATM F2516C unknown
ATM F2571Yfs*4 loss of function - predicted Olaparib
ATM F2732V loss of function - predicted Olaparib
ATM F2827C loss of function Olaparib
ATM F2839L unknown
ATM F570L unknown
ATM F582L unknown
ATM F858L no effect - predicted
ATM F897I unknown
ATM G1459R unknown
ATM G2023R unknown
ATM G2083* loss of function - predicted Olaparib
ATM G2287A no effect - predicted
ATM G2694R unknown
ATM G2695A unknown
ATM G2695C unknown
ATM G2695S unknown
ATM G2718_K2756del loss of function Olaparib
ATM G2765S loss of function Olaparib
ATM G2772R no effect - predicted
ATM G2867R loss of function Olaparib
ATM G2891D unknown
ATM G2891R unknown
ATM G514D unknown
ATM H1380Y loss of function - predicted Olaparib
ATM H1436Y unknown
ATM H2038D unknown
ATM H2038R unknown
ATM H2038Y loss of function - predicted Olaparib
ATM H2554D loss of function Olaparib
ATM H2872Q unknown
ATM H2872R unknown
ATM I10fs loss of function - predicted Olaparib
ATM I124V unknown
ATM I1294Nfs*8 loss of function - predicted Olaparib
ATM I1441fs loss of function - predicted Olaparib
ATM Q1331H ATM I1441fs
ATM I1453fs loss of function - predicted Olaparib
ATM I1581Nfs*5 loss of function - predicted Olaparib
ATM I1681V loss of function Olaparib
ATM I1849fs loss of function - predicted Olaparib
ATM I2629fs loss of function - predicted Olaparib
ATM I2629fs ATM neg
ATM I2701Nfs*17 loss of function - predicted Olaparib
ATM I2888L unknown
ATM I2888M unknown
ATM I2888T unknown
ATM I323V unknown
ATM inact mut loss of function Olaparib
ATM LOH ATM inact mut
ATM inact mut ATM loss
ATM K1410* loss of function - predicted Olaparib
ATM K1773N unknown
ATM K1807E loss of function Olaparib
ATM K1964E unknown
ATM K1992T no effect - predicted
ATM K224E unknown
ATM K2749I loss of function - predicted Olaparib
ATM K2756* loss of function - predicted Olaparib
ATM K2811fs loss of function - predicted Olaparib
ATM K293* loss of function Olaparib
ATM K3018Q unknown
ATM K3043R unknown
ATM K468Efs*18 loss of function - predicted Olaparib
ATM K468fs loss of function - predicted Olaparib
ATM L100W unknown
ATM L1046R unknown
ATM L1239fs loss of function - predicted Olaparib
ATM L1322I no effect - predicted
ATM L1408F unknown
ATM L1408I unknown
ATM L1420F no effect - predicted
ATM L1439I unknown
ATM L1449* loss of function - predicted Olaparib
ATM L1465P loss of function Olaparib
ATM L15fs loss of function - predicted Olaparib
ATM L1675F unknown
ATM L1874F loss of function - predicted Olaparib
ATM L1939V unknown
ATM L1956H loss of function - predicted Olaparib
ATM L2077I unknown
ATM L2307F loss of function
ATM L2332P unknown
ATM L2338P loss of function Olaparib
ATM L2427P loss of function Olaparib
ATM L2427_R2428del loss of function Olaparib
ATM L2452P loss of function Olaparib
ATM L2492R unknown
ATM L2561M unknown
ATM L2572fs loss of function - predicted Olaparib
ATM L259I unknown
ATM L2722M unknown
ATM L2738* loss of function - predicted Olaparib
ATM L2780R unknown
ATM L2877F unknown
ATM L2890I unknown
ATM L2890P unknown
ATM L2890R unknown
ATM L2890V loss of function - predicted Olaparib
ATM L2953Tfs*3 loss of function - predicted Olaparib
ATM L2995I unknown
ATM L348_M349insYIV unknown
ATM L546V no effect
ATM L581V no effect - predicted
ATM L694R unknown
ATM L762Qfs*4 loss of function - predicted Olaparib
ATM L804fs loss of function - predicted Olaparib
ATM L804fs ATM S978fs RET M918T
ATM L822V unknown
ATM L942I unknown
ATM L991S unknown
ATM LOH unknown
ATM P1069fs ATM LOH
ATM loss loss of function Olaparib
ATM S214Pfs*16 ATM loss
ATM S214Ffs*40 ATM loss
ATM M1484Rfs*15 loss of function - predicted Olaparib
ATM M2405L unknown
ATM M2520fs loss of function - predicted Olaparib
ATM M2531T unknown
ATM M349K unknown
ATM M779I unknown
ATM mutant unknown
ATM mut NRAS Q61R
ATM mut CHEK2 mut
ATM N1356D unknown
ATM N1650S unknown Olaparib
ATM N2326_K2363del loss of function - predicted Olaparib
ATM N2603S unknown
ATM N2875H unknown
ATM N2875K unknown
ATM N2875S unknown
ATM N2875T unknown
ATM N3033* loss of function Olaparib
ATM N358I unknown
ATM N765Kfs*12 loss of function - predicted Olaparib
ATM N796H unknown
ATM N81Tfs*20 loss of function - predicted Olaparib
ATM N914S unknown
ATM negative loss of function Olaparib
ATM T2333fs ATM neg
ATM over exp no effect
ATM P1054R no effect
ATM P1069fs loss of function - predicted Olaparib
ATM P1235L unknown
ATM P178S unknown
ATM P2353H unknown
ATM P2353T unknown
ATM P2665T unknown
ATM P2699L loss of function Olaparib
ATM P2699S unknown Olaparib
ATM P2842L unknown
ATM P292L loss of function Olaparib
ATM P2974L loss of function Olaparib
ATM P604S loss of function - predicted Olaparib
ATM P631S unknown
ATM P80S unknown
ATM P960H loss of function - predicted Olaparib
ATM positive unknown
ATM Q1128R unknown
ATM Q1171Tfs*8 loss of function - predicted Olaparib
ATM Q1331H unknown
ATM Q1537R unknown
ATM Q1579fs loss of function - predicted Olaparib
ATM Q1627* loss of function - predicted Olaparib
ATM Q1636Rfs*10 loss of function - predicted Olaparib
ATM Q1906* loss of function - predicted Olaparib
ATM Q1919P unknown
ATM Q1970* loss of function - predicted Olaparib
ATM Q2066L unknown
ATM Q2277* loss of function - predicted Olaparib
ATM Q2297* loss of function - predicted Olaparib
ATM Q2397* loss of function - predicted Olaparib
ATM Q2442P unknown
ATM Q2522fs loss of function - predicted Olaparib
ATM Q2729H unknown
ATM Q2730P loss of function Olaparib
ATM Q2730R unknown
ATM Q2762R unknown
ATM Q2800* loss of function - predicted Olaparib
ATM Q2809P unknown
ATM Q284* loss of function - predicted Olaparib
ATM Q2972* loss of function - predicted Olaparib
ATM Q3038* unknown
ATM Q628Pfs*7 loss of function - predicted Olaparib
ATM R1150I unknown
ATM R1304* loss of function - predicted Olaparib
ATM R1466* loss of function - predicted Olaparib
ATM R1466P unknown
ATM R1466Q unknown
ATM R1575H no effect
ATM R1618* loss of function - predicted Olaparib
ATM R1730* loss of function - predicted Olaparib
ATM R1730Q unknown
ATM R1875* loss of function - predicted Olaparib
ATM R1882* loss of function - predicted Olaparib
ATM R1882* ATM R3008H
ATM R1898* loss of function - predicted Olaparib
ATM R1918T unknown
ATM R2032K unknown
ATM R2034* loss of function - predicted Olaparib
ATM R2034P loss of function - predicted Olaparib
ATM R2138Kfs*8 loss of function - predicted Olaparib
ATM R221I unknown
ATM R23Q unknown
ATM R2443P unknown
ATM R2443Q unknown
ATM R2459C unknown
ATM R248Q unknown
ATM R250* loss of function - predicted Olaparib
ATM R2506_N2543del loss of function Olaparib
ATM R250Sfs*3 loss of function - predicted Olaparib
ATM R2526S unknown
ATM R2547_S2549del loss of function Olaparib
ATM R2598* loss of function - predicted Olaparib
ATM R2598Q unknown
ATM R2691C loss of function - predicted Olaparib
ATM R2832C loss of function Olaparib
ATM R2832S unknown
ATM R2849* loss of function - predicted Olaparib
ATM R2849P loss of function Olaparib
ATM R2854C unknown
ATM R2912Efs*26 loss of function - predicted Olaparib
ATM R2912G unknown
ATM R2993* loss of function - predicted Olaparib
ATM R3008C loss of function Olaparib
ATM R3008H loss of function Olaparib
ATM R3008L unknown
ATM R3008X unknown
ATM R3047* loss of function - predicted Olaparib
ATM R337C unknown
ATM R337H unknown
ATM R337S loss of function Olaparib
ATM R337X unknown
ATM R45Q no effect - predicted
ATM R805* loss of function - predicted Olaparib
ATM R832C unknown
ATM S1135_K1192del unknown Olaparib
ATM S131* loss of function - predicted Olaparib
ATM S1403fs loss of function - predicted Olaparib
ATM S1455R loss of function Olaparib
ATM S1455Vfs*3 loss of function - predicted Olaparib
ATM S1691R no effect
ATM S1905Ifs*25 loss of function - predicted Olaparib
ATM S1983N unknown
ATM S1993fs loss of function - predicted Olaparib
ATM W1058* ATM S1993fs
ATM S1993Rfs*23 loss of function - predicted Olaparib
ATM S2017fs loss of function - predicted Olaparib
ATM S2017T unknown
ATM S214Ffs*40 loss of function - predicted
ATM S214fs loss of function - predicted Olaparib
ATM S214Pfs*16 loss of function - predicted Olaparib
ATM S2190* loss of function - predicted
ATM S2394L loss of function Olaparib
ATM S2407* loss of function - predicted Olaparib
ATM S2489F unknown
ATM S2592C loss of function Olaparib
ATM S2685T no effect
ATM S2707C no effect - predicted
ATM S2761Vfs*41 loss of function - predicted Olaparib
ATM S2812Vfs*3 loss of function - predicted Olaparib
ATM S2812Y unknown
ATM S2855_V2856delinsRI loss of function Olaparib
ATM S2859F unknown
ATM S2860del unknown
ATM S3001N unknown
ATM S3027I unknown
ATM S333F loss of function Olaparib
ATM S421* loss of function - predicted Olaparib
ATM S49C unknown
ATM S707P unknown
ATM S719* loss of function - predicted Olaparib
ATM S751* loss of function - predicted Olaparib
ATM S824F loss of function - predicted Olaparib
ATM S978A unknown
ATM S978C unknown
ATM S978fs loss of function - predicted Olaparib
ATM S978P unknown
ATM S99G unknown
ATM T1200Lfs*7 loss of function - predicted Olaparib
ATM T1200Lfs*7 NRAS Q61K TP53 R213*
ATM T1350M unknown
ATM T1743I loss of function Olaparib
ATM T1756I unknown
ATM T1880R unknown
ATM T2031I no effect - predicted
ATM T2333fs loss of function - predicted Olaparib
ATM T2333Nfs*40 loss of function - predicted Olaparib
ATM T2396S unknown
ATM T2666A loss of function Olaparib
ATM T2743M unknown
ATM T2902fs loss of function - predicted Olaparib
ATM T2934I unknown
ATM T2947S loss of function - predicted Olaparib
ATM T593del unknown
ATM T86I unknown
ATM V1268* loss of function - predicted Olaparib
ATM V1268fs loss of function - predicted Olaparib
ATM V1538fs loss of function - predicted Olaparib
ATM V1570A unknown
ATM V1671D unknown
ATM V1841I no effect - predicted
ATM V1941L loss of function Olaparib
ATM V2119fs loss of function - predicted Olaparib
ATM V2288fs loss of function - predicted Olaparib
ATM V2424G loss of function Olaparib
ATM V2439A unknown
ATM V2664del loss of function
ATM V2716A loss of function Olaparib
ATM V2727A unknown
ATM V2731G unknown
ATM V278fs loss of function - predicted Olaparib
ATM V2873I unknown
ATM V2951F unknown
ATM V410A unknown
ATM V519I loss of function - predicted Olaparib
ATM V566Ifs*6 loss of function - predicted Olaparib
ATM V60F unknown
ATM V630M unknown
ATM W1058* loss of function - predicted Olaparib
ATM W2104* loss of function - predicted Olaparib
ATM W2109* loss of function - predicted Olaparib
ATM W2300* loss of function - predicted Olaparib
ATM W2845C unknown
ATM W3052C unknown
ATM W412* loss of function - predicted Olaparib
ATM W412C unknown
ATM W524* loss of function - predicted Olaparib
ATM W57* loss of function - predicted Olaparib
ATM wild-type no effect
ATM wild-type TP53 mut
ATM Y1124F unknown
ATM Y1229* loss of function - predicted Olaparib
ATM Y1442* loss of function - predicted Olaparib
ATM Y1961C loss of function Olaparib
ATM Y2019C loss of function - predicted Olaparib
ATM Y2371* loss of function - predicted Olaparib
ATM Y2398C unknown
ATM Y2437C unknown
ATM Y2437S unknown
ATM Y2755C unknown
ATM Y2954C unknown
ATM Y54* loss of function - predicted Olaparib