Gene Detail

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Gene Symbol BRAF
Synonyms B-raf | B-RAF1 | BRAF1 | NS7 | RAFB1
Gene Description BRAF, serine/threonine-protein kinase B-raf, is a member of the Raf family of serine/threonine protein kinases, which signals through the MAP kinase pathway to regulate cell proliferation and cell growth (PMID: 24737949, PMID: 29540830). BRAF mutations and fusions have been identified in a variety of cancers, including, colorectal (PMID: 30122982), lung (PMID: 29729495), thyroid (PMID: 12970315), and melanoma (PMID: 24737949), and a number of mutations have also been demonstrated to confer drug resistance (PMID: 27478040).

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Molecular Profile Protein Effect Treatment Approaches
BRAF A320T no effect - predicted
BRAF A598S unknown
BRAF A598T loss of function - predicted
BRAF A598V gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF A598X unknown
BRAF A598_T599insARC gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF A598_T599insV gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF A712T no effect - predicted
BRAF A728V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF A762E unknown
BRAF A762V no effect - predicted
BRAF A81_D380del gain of function - predicted
BRAF A81_M438del gain of function - predicted
BRAF act mut gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF amp no effect
BRAF V600X BRAF amp NRAS Q61K
BRAF V600E BRAF amp
BRAF D287H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF D380H no effect - predicted
BRAF D587A unknown
BRAF D587E unknown
BRAF D587G unknown
BRAF D594A loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF D594E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF D594G unknown
BRAF D594G NRAS G12D
BRAF D594H loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF D594N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF D594V loss of function
BRAF D594X unknown
BRAF D594Y unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF D594_T599dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF dec exp no effect
BRAF E228V no effect - predicted
BRAF E275K unknown
BRAF E451K gain of function - predicted
BRAF E501G loss of function
BRAF E501K unknown
BRAF E586K gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF E586X unknown
BRAF E611D unknown
BRAF E648Q loss of function - predicted
BRAF E695K unknown
BRAF F247L gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF F259L no effect - predicted
BRAF F294L no effect - predicted
BRAF F468C gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF F595L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF F595S unknown
BRAF F595X unknown
BRAF fusion unknown
BRAF G104E no effect - predicted
BRAF G203_G393del gain of function - predicted
BRAF G258V unknown
BRAF G421V no effect - predicted
BRAF G464E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G464R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G464V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G464X unknown
BRAF G466A unknown
BRAF G466E unknown
BRAF G466E HRAS Q61K
BRAF G466R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G466V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G466V NRAS Q61K
BRAF G466X unknown
BRAF G469A gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469del loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469E unknown
BRAF G469L unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469R gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469R NRAS Q61K
BRAF G469S gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469V NRAS Q61K
BRAF G469X unknown
BRAF G478C loss of function - predicted
BRAF G563D loss of function - predicted
BRAF G593D no effect - predicted
BRAF G596C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G596D unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G596fs loss of function - predicted
BRAF G596R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G596R PIK3CA E545K
BRAF G596R NRAS Q61K
BRAF G596R PTPN11 E76K
BRAF G596S unknown
BRAF G596V loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G596V NRAS G13R
BRAF G596X unknown
BRAF G606A unknown
BRAF G606E unknown
BRAF G606V unknown
BRAF G606W loss of function - predicted
BRAF G615R loss of function - predicted
BRAF G69S unknown
BRAF H269Y unknown
BRAF H568D loss of function - predicted
BRAF H574N no effect - predicted
BRAF H574Q gain of function
BRAF H585Y loss of function - predicted
BRAF H608R unknown
BRAF H725Y unknown
BRAF I463S gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF I463T unknown
BRAF I463X unknown
BRAF I582M unknown
BRAF I592M unknown
BRAF I592V unknown
BRAF inact mut loss of function
BRAF K205Q no effect - predicted
BRAF K483E unknown
BRAF K483M unknown
BRAF K499E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K499N unknown
BRAF K601del unknown
BRAF K601E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF S363F BRAF K601E
BRAF K601E MAP2K1 V211D
BRAF K601I unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K601N gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K601Q gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K601T gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K601X unknown
BRAF K601_S602delinsNT unknown
BRAF K698R no effect - predicted
BRAF L245F unknown
BRAF L485F gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L485S gain of function - predicted
BRAF L485W unknown
BRAF L485X unknown
BRAF L485Y unknown
BRAF L485_P490del gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L485_P490delinsF gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L485_P490delinsY gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L485_Q494del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L505H gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L505H BRAF V600E
BRAF L514V gain of function - predicted
BRAF L514V BRAF V600E
BRAF L584F unknown
BRAF L597P unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L597Q gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L597R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L597S gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF R239Q BRAF L597S
BRAF L597V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L597V NRAS Q61K
BRAF L597X unknown
BRAF L613F unknown
BRAF L618F loss of function - predicted
BRAF L64I no effect - predicted
BRAF L678I loss of function - predicted
BRAF L711F no effect - predicted
BRAF M517I loss of function - predicted
BRAF M53I unknown
BRAF mutant unknown
BRAF mut PIK3CA mut
BRAF mut NRAS mut
BRAF mut NRAS wild-type
BRAF mut STAG2 dec exp
BRAF mut RB1 loss
BRAF mut PTPN11 dec exp
BRAF mut PIK3CA wild-type
BRAF mut IDH1 wild-type
BRAF N20T unknown
BRAF N486D unknown
BRAF N486_A489delinsK unknown
BRAF N486_P490del gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF N486_T491delinsK gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF N49I no effect - predicted
BRAF N581D no effect - predicted
BRAF N581I unknown
BRAF N581K loss of function - predicted
BRAF N581S unknown
APC Q1429fs BRAF N581S ERBB2 L755S
BRAF N581T no effect - predicted
BRAF N581X unknown
BRAF N581Y unknown
BRAF P141L no effect - predicted
BRAF P162S no effect - predicted
BRAF P341S no effect - predicted
BRAF P348T no effect - predicted
BRAF P367L unknown
BRAF P367R gain of function
BRAF P367S unknown
BRAF P367X unknown
BRAF P403fs loss of function - predicted
BRAF P407L no effect - predicted
BRAF P453T unknown
BRAF P490_Q494del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF P676S no effect - predicted
BRAF P731S unknown
BRAF P731T unknown
BRAF Q257H unknown
BRAF Q257R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF Q257X unknown
BRAF Q262R unknown
BRAF Q609E unknown
BRAF Q609H no effect - predicted
BRAF Q609L unknown
BRAF R188T no effect - predicted
BRAF R239Q unknown
BRAF R271H no effect - predicted
BRAF R347* loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF R389C no effect - predicted
BRAF R444W unknown
BRAF R462I unknown
BRAF R462K no effect - predicted
BRAF R462X unknown
BRAF R509G no effect - predicted
BRAF R509H loss of function
BRAF R603* loss of function - predicted
BRAF R671Q no effect - predicted
BRAF R719S no effect - predicted
BRAF rearrange unknown
BRAF S363F unknown
BRAF S364L no effect - predicted
BRAF S36A unknown
BRAF S419Y no effect - predicted
BRAF S465A no effect - predicted
BRAF S465D no effect - predicted
BRAF S465E loss of function - predicted
BRAF S467A gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF S467L unknown
BRAF S467X unknown
BRAF S602F no effect - predicted
BRAF S602T unknown
BRAF S605A loss of function - predicted
BRAF S605E loss of function - predicted
BRAF S605F unknown
BRAF S605G loss of function - predicted
BRAF S605N unknown
BRAF S607F unknown
BRAF S607P no effect - predicted
BRAF S637* loss of function - predicted
BRAF T241P unknown
BRAF T241X unknown
BRAF T310I gain of function - predicted
BRAF T401I no effect - predicted
BRAF T470K no effect - predicted
BRAF T488_P492del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T488_Q493delinsK gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T529I unknown
BRAF T529I BRAF V600E
BRAF T529M unknown
BRAF T529M BRAF V600E
BRAF T529N unknown
BRAF T529N BRAF V600E
BRAF T599A loss of function
BRAF T599dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599I gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599K gain of function - predicted
BRAF T599R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599X unknown
BRAF T599_V600insEAT gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599_V600insETT gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599_V600insS unknown
BRAF T599_V600insTT gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V169_D380del gain of function - predicted
BRAF V169_G327del gain of function - predicted
BRAF V226L unknown
BRAF V459L unknown
BRAF V471F loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V471I unknown
BRAF V47_D380del gain of function - predicted
BRAF V47_D380del BRAF V600E
BCORL1 Q1076H BRAF V47_D380del BRAF V600E
BRAF V47_G327del gain of function - predicted
BRAF V47_G393del gain of function - predicted
BRAF V47_M438del gain of function - predicted
BRAF V487_P492delinsA gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V504I no effect - predicted
BRAF V504_R506dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V590G unknown
BRAF V590I unknown
BRAF V600A no effect - predicted
BRAF V600D gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600D NRAS dec exp
BRAF V600delinsYM gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V600dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V600E gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600E NRAS Q61K
BRAF V600E MAP2K1 C121S
BRAF V600E PIK3CA P449T
BRAF V600E NRAS G12V
BRAF V600E MAP2K1 L115P
BRAF V600E MAP2K1 I103N
BRAF V600E MAP2K1 V211D
BRAF V600E MAP2K1 P387S NRAS A146T
BRAF V600E NRAS A146T
BRAF V600E MAP2K1 P387S NRAS Q61K
BRAF V600E MAP2K1 K59del
BRAF V600E MAP2K1 P387S NRAS Q61K NRAS A146T
BRAF V600E MAP2K1 Q56P
BRAF V600E NRAS Q61K NRAS A146T
BRAF V600E CSF1R pos
BRAF V600E CDKN2A mut
BRAF V600E MAP2K1 H119P
BRAF V600E MAP2K1 V60E
BRAF V600E MAP2K1 P124S
BRAF V600E MAP2K1 G128V
BRAF V600E MAP2K1 P162S
BRAF V600E MAP2K1 K57E
BRAF V600E MAP2K1 P124Q
BRAF V600E PIK3CA H1047R
BRAF V600E PIK3CA H1047K
BRAF V600E PIK3CA mut
BRAF V600E MAP2K1 I111N
BRAF V600E MAP2K1 E203K
BRAF V600E MAP2K1 P124L
BRAF V600E MAP2K1 K57T
BRAF V600E NRAS G13R
BRAF V600E NRAS amp
BRAF V600E NRAS over exp
BCORL1 Q1076H BRAF V600E
BRAF V600E MAP2K1 I99T
BRAF V600E MAP2K1 I99G
BRAF V600E MAP2K1 I99M
BRAF V600E STAG2 K1083*
BRAF V600E STAG2 D193N
BRAF V600E/K gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600E/K PIK3CA wild-type
BRAF V600fs loss of function - predicted
BRAF V600G gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600K gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600K NRAS Q61K
BRAF V600K MAP2K1 P124Q
BRAF V600K MAP2K1 P124L
BRAF V600L unknown BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600M gain of function - predicted BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600Q unknown BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600R gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600X unknown BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V600X PIK3CA H1047X
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
BRAF V600_K601delinsE gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V639I no effect - predicted
BRAF V681I no effect - predicted
BRAF W450* loss of function - predicted
BRAF W531C unknown
BRAF W604del unknown
BRAF W604G unknown
BRAF W604R unknown
BRAF W619R unknown
BRAF wild-type no effect
BRAF wild-type NRAS mut
BRAF wild-type KIT pos
BRAF wild-type NRAS wild-type
BRAF wild-type NRAS Q61K
BRAF wild-type ERBB2 amp NRAS wild-type
BRAF Y472C unknown
BRAF Y538H unknown
BRAF Y656D loss of function - predicted