Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene FLT3
Variant exon 14 ins
Impact List indel
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 exon 14 ins refers to a series of internal tandem duplications (ITD) typically occurring in exon 14 and within the juxtamembrane domain of the Flt3 protein (PMID: 12970773). Exon 14 ins mutations often result in constitutive activation of Flt3 (PMID: 12970773) and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FLT3 exon 14 ins gain of function - predicted FLT3 Inhibitor
FLT3 exon 14 ins FLT3 F691L
FLT3 exon 14 ins FLT3 D835Y
FLT3 exon 14 ins FLT3 D835V
FLT3 exon 14 ins FLT3 D835F
FLT3 exon 14 ins FLT3 Y842H
FLT3 exon 14 ins FLT3 Y842C
FLT3 exon 14 ins FLT3 R834Q
FLT3 exon 14 ins FLT3 F691L FLT3 R834Q
FLT3 exon 14 ins FLT3 D835E
FLT3 exon 14 ins FLT3 F691L FLT3 D835E
FLT3 exon 14 ins FLT3 D835H
FLT3 exon 14 ins FLT3 F691L FLT3 D835H
FLT3 exon 14 ins FLT3 D835N
FLT3 exon 14 ins FLT3 F691L FLT3 D835N
FLT3 exon 14 ins FLT3 F691L FLT3 D839G
FLT3 exon 14 ins FLT3 D839G
FLT3 exon 14 ins FLT3 D839H
FLT3 exon 14 ins FLT3 F691L FLT3 Y842C
FLT3 exon 14 ins FLT3 F691L FLT3 Y842H
FLT3 exon 14 ins FLT3 M837G FLT3 S838R FLT3 D839H
FLT3 exon 14 ins FLT3 D835G
FLT3 exon 14 ins FLT3 F691L FLT3 D835G
FLT3 exon 14 ins FLT3 D698N
FLT3 exon 14 ins FLT3 F691L FLT3 D698N
FLT3 exon 14 ins FLT3 D839A
FLT3 exon 14 ins FLT3 F691L FLT3 D839A
FLT3 exon 14 ins FLT3 D839N
FLT3 exon 14 ins FLT3 F691L FLT3 D839N
FLT3 exon 14 ins FLT3 G846R
FLT3 exon 14 ins FLT3 F691L FLT3 G846R
FLT3 exon 14 ins FLT3 M664I
FLT3 exon 14 ins FLT3 M664I FLT3 F691L
FLT3 exon 14 ins FLT3 N676S
FLT3 exon 14 ins FLT3 N676S FLT3 F691L
FLT3 exon 14 ins FLT3 N841K
FLT3 exon 14 ins FLT3 F691L FLT3 N841K
FLT3 exon 14 ins FLT3 R845G
FLT3 exon 14 ins FLT3 F691L FLT3 R845G
FLT3 exon 14 ins FLT3 T820A
FLT3 exon 14 ins FLT3 Y842S
FLT3 exon 14 ins FLT3 F691L FLT3 Y842S
FLT3 exon 14 ins FLT3 F691L FLT3 D835Y
FLT3 exon 14 ins FLT3 S652G
FLT3 exon 14 ins FLT3 N676D FLT3 Y842C
FLT3 exon 14 ins FLT3 D835X
FLT3 exon 14 ins FLT3 F691I
FLT3 exon 14 ins FLT3 N676D
FLT3 exon 14 ins FLT3 A848P
FLT3 exon 14 ins FLT3 F621L
FLT3 exon 14 ins FLT3 LOH
FLT3 exon 14 ins FLT3 E654D
FLT3 exon 14 ins FLT3 G697R
FLT3 exon 14 ins FLT3 Y842R
FLT3 exon 14 ins FLT3 D835A
FLT3 exon 14 ins FLT3 D835I
FLT3 exon 14 ins FLT3 A627P
FLT3 exon 14 ins FLT3 N676T
FLT3 exon 14 ins FLT3 F691L FLT3 D835I
FLT3 exon 14 ins NRAS G12D
FLT3 exon 14 ins IDH2 R140Q
FLT3 exon 14 ins JAK2 V617F
FLT3 exon 14 ins JAK3 V722I
FLT3 exon 14 ins JAK3 R953*
FLT3 exon 14 ins FLT3 A627T
FLT3 exon 14 ins FLT3 N701K
FLT3 exon 14 ins FLT3 N676K
FLT3 exon 14 ins FLT3 C695S
FLT3 exon 14 ins NRAS Q61K
FLT3 exon 14 ins NRAS G12C
FLT3 exon 14 ins FLT3 Y693F
FLT3 exon 14 ins FLT3 Y693C
FLT3 exon 14 ins FLT3 Y693N
FLT3 exon 14 ins FLT3 G697S
FLT3 exon 14 ins FLT3 C681S
FLT3 exon 14 ins FLT3 C790S
FLT3 exon 14 ins FLT3 C807S
FLT3 exon 14 ins FLT3 C828S
FLT3 exon 14 ins FLT3 C694S
FLT3 exon 14 ins FLT3 K429E
FLT3 exon 14 ins FLT3 F691L FLT3 D835V
FLT3 exon 14 ins FLT3 D698N FLT3 D835V
FLT3 exon 14 ins FLT3 Y693C FLT3 D835V
FLT3 exon 14 ins FLT3 D835del
FLT3 exon 14 ins IDH1 R132H
FLT3 exon 14 ins FLT3 N841Y
FLT3 exon 14 ins FLT3 I836del
FLT3 exon 14 ins FLT3 M855T
FLT3 exon 14 ins FLT3 N841H
FLT3 exon 14 ins FLT3 E778K
FLT3 exon 14 ins FLT3 E786K
FLT3 exon 14 ins FLT3 G631R
FLT3 exon 14 ins FLT3 G669R
FLT3 exon 14 ins FLT3 G757E
FLT3 exon 14 ins FLT3 G846D
FLT3 exon 14 ins FLT3 G846S
FLT3 exon 14 ins FLT3 H721Y
FLT3 exon 14 ins FLT3 M837I
FLT3 exon 14 ins FLT3 M837K
FLT3 exon 14 ins FLT3 N609T
FLT3 exon 14 ins FLT3 N841T
FLT3 exon 14 ins FLT3 S705N
FLT3 exon 14 ins FLT3 G822E
FLT3 exon 14 ins FLT3 N841I
FLT3 exon 14 ins FLT3 G697S FLT3 D835V
FLT3 exon 14 ins FLT3 Y693N FLT3 D835V
KMT2A rearrange FLT3 exon 14 ins
FLT3 exon 14 ins FLT3 V843A
FLT3 exon 14 ins FLT3 D835X NRAS G13D
FLT3 exon 14 ins FLT3 D835X NRAS G12D NRAS G12S
FLT3 exon 14 ins FLT3 F691L FLT3 D835X
FLT3 exon 14 ins FLT3 D835X NRAS G13R
CBL Q367_E373delinsRLK FLT3 exon 14 ins FLT3 D835X NRAS G12D
FLT3 exon 14 ins FLT3 D835X NRAS Q61K
BRAF G469A CBL C404Y FLT3 exon 14 ins FLT3 D835X
FLT3 exon 14 ins FLT3 D835X NRAS Q61R
FLT3 exon 14 ins FLT3 D835X NRAS G13C NRAS G13R
FLT3 exon 14 ins FLT3 D835X NRAS Q61H
FLT3 exon 14 ins FLT3 C35S
FLT3 exon 14 ins FLT3 V843I
FLT3 exon 14 ins FLT3 G846C
FLT3 exon 14 ins FLT3 Y842D
FLT3 exon 14 ins FLT3 M837_D839delinsGRH
FLT3 exon 14 ins TET2 mut
DNMT3A mut FLT3 exon 14 ins TET2 mut
FLT3 exon 14 ins TET2 loss
DNMT3A loss FLT3 exon 14 ins TET2 loss
DNMT3A loss FLT3 exon 14 ins