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Gene Symbol ALK
Synonyms ALK1 | CD246 | NBLST3
Gene Description ALK, anaplastic lymphoma kinase, is a receptor in the insulin receptor superfamily and is a key regulator of neuronal development (PMID: 21502284) and also promotes cell proliferation through activation of MAPK and PI3K signaling pathways (PMID: 27573755). Alk activating mutations, rearrangements, and fusions have been identified in various cancers (PMID: 22649787), including EML4-ALK in non-small cell lung cancer (PMID: 30108712, PMID: 30194140), and a number of mutations confer resistance in the context of Alk fusions (PMID: 25749034, PMID: 21948233).

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Molecular Profile Protein Effect Treatment Approaches
ALK A1015T unknown
ALK A1047T unknown
ALK A1200V no effect - predicted
EML4 - ALK ALK A1200V
ALK A1200_G1201delinsW unknown
EML4 - ALK ALK A1200_G1201delinsW
ALK A1251T loss of function - predicted
ALK A1252V no effect - predicted
ALK A1266D unknown
ALK A1266V no effect - predicted
ALK A195V no effect - predicted
ALK A348D gain of function ALK Inhibitor
ALK A528T unknown
ALK A585T no effect - predicted
ALK act mut gain of function ALK Inhibitor
ALK act mut TP53 wild-type
ALK amp no effect
ALK amp TP53 wild-type
ALK rearrange ALK amp
ALK F1174V ALK amp
ALK F1174L ALK amp
ALK amp ALK pos
ALK F1174V ALK amp TP53 wild-type
ALK F1174L ALK G1202R ALK D1203N ALK amp
ALK del exon2 ALK del exon3 ALK amp
ALK C1021V no effect - predicted
ALK C1097A no effect - predicted
ALK C1156F unknown
ALK C1156Y unknown
EML4 - ALK ALK C1156Y Alectinib Brigatinib Ensartinib Lorlatinib
ALK fusion ALK C1156Y
ALK rearrange ALK C1156Y
ALK rearrange ALK C1156Y ALK L1198F
EML4 - ALK ALK C1156Y ALK L1198F Crizotinib
EML4 - ALK ALK C1156Y ALK L1196M
EML4 - ALK ALK C1156Y ALK I1171T
EML4 - ALK ALK C1156Y ALK F1174C
EML4 - ALK ALK C1156Y ALK F1174I
EML4 - ALK ALK C1156Y ALK F1174V
EML4 - ALK ALK C1156Y ALK D1203N
EML4 - ALK ALK C1156Y ALK L1256F
EML4 - ALK ALK C1156Y ALK G1269A
ALK C1156Y ALK pos
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK C1156Y ALK G1202R
EML4 - ALK ALK C1156Y ALK L1196M ALK G1202R
ALK C1156Y ALK L1198F
ALK fusion ALK C1156Y ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171N
EML4 - ALK ALK C1156Y ALK I1171N ALK L1198F
EML4 - ALK ALK C1156Y ALK I1171T ALK L1198F
ALK C1235R unknown
EML4 - ALK ALK C1235R ALK C1237Y
ALK C1237Y gain of function - predicted
EML4 - ALK ALK C1237Y
ALK C928Lfs*20 loss of function - predicted
ALK C990R unknown
ALK D1091N unknown
ALK D1163N gain of function - predicted ALK Inhibitor
ALK D1203fs loss of function - predicted
ALK D1203N unknown
EML4 - ALK ALK D1203N Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK F1174C ALK D1203N
EML4 - ALK ALK D1203N ALK E1210K Lorlatinib
ALK rearrange ALK I1171N ALK D1203N
ALK rearrange ALK D1203N ALK E1210K ALK G1269A
ALK rearrange ALK D1203N
EML4 - ALK ALK F1174L ALK D1203N ALK G1269A
ALK rearrange ALK L1196M ALK D1203N
EML4 - ALK ALK L1196M ALK D1203N
EML4 - ALK ALK D1203N ALK F1245V
ALK D1203N ALK E1210K
EML4 - ALK ALK I1171N ALK D1203N
ALK fusion ALK D1203N ALK E1210K ALK G1269A
EML4 - ALK ALK L1196M ALK G1202R ALK D1203N
EML4 - ALK ALK I1171T ALK F1174L ALK L1196M ALK D1203N ALK E1210K ALK G1269A
ALK D1225N unknown
ALK D1249fs loss of function - predicted
ALK D1270G loss of function - predicted
ALK D1276_R1279delinsE gain of function
ALK G1202R ALK D1276_R1279delinsE
ALK D1311N no effect - predicted
ALK D1349H unknown
ALK D1529E no effect - predicted
ALK D1529G unknown
ALK D94N unknown
ALK del exon2 unknown
ALK del exon2-19 unknown
ALK del exon3 unknown
ALK del exon4-11 gain of function
ALK E1129V unknown
EML4 - ALK ALK E1129V ALK I1171T ALK F1174C ALK F1174L ALK F1174V ALK G1269A
ALK rearrange ALK E1129V
EML4 - ALK ALK E1129V
EML4 - ALK ALK E1129V ALK G1202R
EML4 - ALK ALK E1129V ALK I1171N
ALK E1154K unknown
EML4 - ALK ALK E1154K ALK G1202R ALK I1268V
ALK E1161A unknown
ALK E1210K unknown
EML4 - ALK ALK E1210K Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK S1206C ALK E1210K
ALK rearrange ALK E1210K
ALK S1206C ALK E1210K
EML4 - ALK ALK F1174C ALK E1210K
EML4 - ALK ALK F1174L ALK E1210K ALK G1269A
EML4 - ALK ALK F1174L ALK E1210K
ALK E1242K unknown
ALK E1303K unknown
EML4 - ALK ALK E1303K
ALK E1400D unknown
ALK E1407K unknown
ALK E310D unknown
ALK E717K unknown
ALK E862D unknown
ALK E994K no effect - predicted
ALK F1098V unknown
ALK F1174C gain of function ALK Inhibitor
EML4 - ALK ALK F1174C Brigatinib Lorlatinib
EML4 - ALK ALK F1174C ALK L1198F Crizotinib
EML4 - ALK ALK F1174C ALK L1196M
EML4 - ALK ALK F1174C ALK G1269A
ALK rearrange ALK F1174C
ALK rearrange ALK F1174C ALK G1202R
EML4 - ALK ALK F1174C ALK G1202R
ALK F1174C TP53 wild-type
ALK F1174I gain of function ALK Inhibitor
EML4 - ALK ALK I1171N ALK F1174I
EML4 - ALK ALK F1174I
EML4 - ALK ALK F1174I ALK G1202R
ALK F1174L gain of function ALK Inhibitor
ALK F1174L TP53 wild-type
EML4 - ALK ALK F1174L Alectinib AZD3463 Lorlatinib
ALK F1174L ALK L1198P
ALK G1123S ALK F1174L
ALK G1123D ALK F1174L
EML4 - ALK ALK F1174L ALK L1196M
EML4 - ALK ALK F1174L ALK L1198V
ALK rearrange ALK F1174L
EML4 - ALK ALK F1174L ALK G1269A
ALK rearrange ALK F1174L ALK G1202R
ALK F1174L ALK pos
EML4 - ALK ALK F1174L ALK G1202R
EML4 - ALK ALK I1171N ALK F1174L
ALK F1174L ALK R1275Q
ALK F1174L RET over exp
EML4 - ALK ALK F1174L ALK S1189C
ALK F1174L NRAS Q61K
ALK F1174L FGFR1 N546K
ALK F1174L PIK3CA H1047R
ALK F1174L ALK L1196M
ALK F1174L ALK G1202R
ALK F1174S gain of function ALK Inhibitor
ALK rearrange ALK F1174S
ALK F1174V gain of function - predicted ALK Inhibitor
EML4 - ALK ALK F1174V Alectinib Brigatinib
EML4 - ALK ALK I1171S ALK F1174V
EML4 - ALK ALK F1174V ALK G1202R
EML4 - ALK ALK F1174V ALK L1196M
ALK F1174V ALK pos
ALK rearrange ALK F1174V
EML4 - ALK ALK I1171T ALK F1174V
ALK F1174X unknown
ALK rearrange ALK F1174X
ALK F1245C gain of function ALK Inhibitor
ALK F1245C TP53 wild-type
EML4 - ALK ALK F1245C Ceritinib
ALK F1245I unknown
ALK F1245L unknown
ALK F1245Q unknown
ALK F1245V gain of function ALK Inhibitor
EML4 - ALK ALK F1245V
ALK I1171T ALK R1192P ALK L1196M ALK F1245V
ALK F1245X unknown
ALK F1245Y unknown
ALK F1245Y HRAS G13R
ALK F1271L unknown
ALK F457L no effect - predicted
ALK F856S gain of function ALK Inhibitor
ALK fusion unknown ALK Inhibitor
ALK fusion ALK T1151dup
ALK fusion ALK L1196M
ALK fusion ALK L1152R
ALK fusion ALK G1269A
ALK fusion ALK S1206Y
ALK fusion ALK G1202R
ALK fusion ALK G1202R KIT amp
ALK fusion ALK L1196M ALK G1202R
ALK fusion ALK G1202R ALK L1204V ALK G1269A
ALK fusion ALK G1202R ALK S1206F ALK G1269A
ALK G1123D unknown
ALK G1123S unknown
ALK rearrange ALK G1123S
EML4 - ALK ALK G1123S
ALK G1128A gain of function ALK Inhibitor
ALK G1128S unknown
ALK G1137R no effect - predicted
ALK G1201E gain of function ALK Inhibitor
ALK G1201R unknown
ALK G1202del unknown
EML4 - ALK ALK G1202del Lorlatinib
ALK rearrange ALK G1202del
ALK G1202K unknown
EML4 - ALK ALK G1202K
ALK G1202L unknown
EML4 - ALK ALK G1202L
ALK G1202R unknown
EML4 - ALK ALK G1202R Brigatinib Lorlatinib
EML4 - ALK ALK L1198F ALK G1202R Crizotinib
ALK rearrange ALK G1202R
EML4 - ALK ALK L1196M ALK G1202R
ALK rearrange ALK G1202R ALK G1269A
ALK rearrange ALK L1196M ALK G1202R
ALK rearrange ALK G1202R ALK L1204V ALK G1269A
ALK rearrange ALK V1180L ALK L1196M ALK G1202R
ALK rearrange ALK T1151M ALK G1202R
ALK G1202R ALK pos
EML4 - ALK ALK G1202R ALK G1269A
EML4 - ALK ALK G1202R ALK L1204V ALK G1269A
EML4 - ALK ALK L1198F ALK G1202R ALK G1269A
EML4 - ALK ALK V1180L ALK G1202R
ALK L1198F ALK G1202R
EML4 - ALK ALK I1171N ALK L1196M ALK G1202R
EML4 - ALK ALK G1202R ALK S1206F
EML4 - ALK ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK T1151K ALK G1202R ALK S1206F
EML4 - ALK ALK T1151M ALK G1202R
EML4 - ALK ALK I1171N ALK G1202R
ALK G1202R ALK R1275Q
ALK G1202R ALK R1275Q BRAF V600E
ALK G1202X unknown
ALK rearrange ALK G1202X
ALK G1269A unknown
EML4 - ALK ALK G1269A Alectinib AZD3463 Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK L1198F ALK G1269A Brigatinib Crizotinib
EML4 - ALK ALK L1196M ALK G1269A
ALK rearrange ALK T1151dup ALK G1269A
EML4 - ALK ALK I1171T ALK G1269A
EML4 - ALK ALK I1171N ALK G1269A
ALK rearrange ALK G1269A
EML4 - ALK ALK I1171S ALK G1269A
ALK L1152V ALK G1269A
ALK G1269E unknown
ALK G1269S gain of function - predicted ALK Inhibitor
EML4 - ALK ALK G1269S
ALK G1286R unknown
ALK G1552R no effect - predicted
ALK G689V unknown
ALK G746C unknown
ALK G875R no effect - predicted
ALK G922R unknown
ALK H1030P unknown
ALK H354Q no effect - predicted
ALK I1170N gain of function ALK Inhibitor
ALK I1170S gain of function ALK Inhibitor
ALK I1170V gain of function - predicted ALK Inhibitor
ALK I1171N gain of function ALK Inhibitor
EML4 - ALK ALK I1171N Brigatinib Ceritinib Lorlatinib
ALK rearrange ALK I1171N
ALK rearrange ALK I1171N ALK L1198F
EML4 - ALK ALK I1171N ALK L1256F
EML4 - ALK ALK I1171N ALK L1198H
EML4 - ALK ALK I1171N ALK L1198F
EML4 - ALK ALK I1171N ALK L1196M
EML4 - ALK ALK I1171N ALK V1180L
ALK I1171N ALK pos
ALK I1171N ALK Y1278S
ALK I1171S unknown
EML4 - ALK ALK I1171S Lorlatinib
EML4 - ALK ALK I1171S ALK L1196M
ALK I1171S ALK pos
ALK rearrange ALK I1171S
ALK I1171T gain of function
EML4 - ALK ALK I1171T Ceritinib Lorlatinib TAE684
ALK rearrange ALK I1171T
ALK I1171T ALK pos
ALK I1171X unknown
ALK rearrange ALK I1171X
ALK I1179V unknown
EML4 - ALK ALK I1179V ALK L1196M
ALK I1183T unknown
ALK I1250T loss of function
ALK I1268V unknown
ALK I1461V unknown
ALK inact mut loss of function
ALK K1062M gain of function ALK Inhibitor
ALK K1491R no effect - predicted
ALK K1518N no effect - predicted
ALK K1525E no effect - predicted
ALK K894T unknown
ALK L1122V unknown
ALK L1152M unknown
ALK L1152P unknown
EML4 - ALK ALK L1152P Brigatinib
ALK L1152R unknown
EML4 - ALK ALK L1152R Brigatinib Lorlatinib
ALK rearrange ALK L1152R
ALK L1152R ALK pos
ALK L1152V unknown
ALK L1152V ALK pos
ALK L1196M gain of function ALK Inhibitor
EML4 - ALK ALK L1196M Brigatinib Ceritinib Ensartinib Entrectinib Lorlatinib Repotrectinib
ALK L1196M ALK S1206C
EML4 - ALK ALK L1196M ALK L1198F
ALK rearrange ALK L1196M
EML4 - ALK ALK L1196M ALK L1198H
EML4 - ALK ALK L1196M ALK L1256F
ALK L1196M ALK pos
ALK L1196M ALK L1198F
ALK L1196M ALK R1275Q
ALK L1196P gain of function - predicted
EML4 - ALK ALK L1196P
ALK L1196Q unknown ALK Inhibitor
EML4 - ALK ALK L1196Q
ALK rearrange ALK L1196Q
ALK L1196X unknown
ALK rearrange ALK L1196X
ALK rearrange ALK L1198F ALK mut
ALK L1198F gain of function ALK Inhibitor
EML4 - ALK ALK L1198F Brigatinib Crizotinib
ALK rearrange ALK L1198F
ALK L1198H unknown
ALK L1198P gain of function - predicted ALK Inhibitor
EML4 - ALK ALK L1198P
ALK L1198R unknown
EML4 - ALK ALK L1198R
ALK L1198V unknown
ALK L1198X unknown
ALK L1204F unknown
ALK L1204V unknown
ALK L1256F unknown
EML4 - ALK ALK L1256F
ALK L1319V unknown
EML4 - ALK ALK L1319V
ALK L560F no effect - predicted
ALK L868Q unknown
ALK M1166R gain of function ALK Inhibitor
ALK M1166V unknown
ALK M1478T unknown
ALK M301I no effect - predicted
ALK M552I no effect - predicted
ALK mutant unknown
ALK mut TP53 wild-type
ALK rearrange ALK mut
ALK N1178H unknown
ALK neg ROS1 pos
ALK negative loss of function
ROS1 rearrange ALK neg
ALK over exp no effect
ALK P1112Q unknown
ALK P1139S unknown
ALK P1213C unknown
ALK P1298S unknown
ALK P1543S unknown
ALK P157S unknown
ALK P1599S unknown
ALK P279L unknown
ALK P336S no effect - predicted
ALK P36S unknown
ALK P40L unknown
ALK P858S no effect - predicted
ALK positive unknown
ALK Q1146K unknown
ALK Q1146P unknown
ALK Q1188_L1190del unknown
EML4 - ALK ALK Q1188_L1190del
ALK R1113Q unknown
ALK R1181H unknown
ALK R1192P gain of function ALK Inhibitor
EML4 - ALK ALK R1192P Alectinib AZD3463 Brigatinib Crizotinib
ALK R1192Q no effect - predicted
ALK R1209Q unknown
ALK R1212C unknown
ALK R1212H unknown
ALK R1231Q unknown
ALK R1275L unknown
ALK R1275Q gain of function ALK Inhibitor
ALK R1275Q TP53 wild-type
ALK R1275Q RET over exp
EML4 - ALK ALK R1275Q
ALK R1275X unknown
ALK R1279Q unknown
ALK R133H no effect - predicted
ALK R284K unknown
ALK R291C unknown
ALK R311H unknown
ALK R395H unknown
ALK R401* loss of function - predicted
ALK R401L gain of function - predicted
ALK R401Q no effect - predicted
ALK R412C no effect - predicted
ALK R753Q gain of function - predicted
ALK rearrange unknown ALK Inhibitor
ALK rearrange MAP2K1 K57N
ALK rearrange RB1 C706F TP53 loss
ALK rearrange ALK S1206Y
ALK rearrange ALK V1180L
ALK rearrange TP53 mut
ALK rearrange ALK V1180X
ALK rearrange ROS1 rearrange
ALK rearrange ALK T1151R
ALK rearrange ALK T1151M
ALK S1053F unknown
ALK S1189C unknown
ALK S1206C unknown
ALK S1206F unknown
EML4 - ALK ALK S1206F Brigatinib
ALK S1206R unknown
EML4 - ALK ALK S1206R
ALK S1206Y unknown
EML4 - ALK ALK S1206Y Brigatinib Ceritinib Lorlatinib
ALK S529Y no effect - predicted
ALK S711R no effect - predicted
ALK S865P no effect - predicted
ALK T1151dup unknown
EML4 - ALK ALK T1151dup Brigatinib
ALK T1151K unknown
EML4 - ALK ALK T1151K
ALK T1151M gain of function - predicted ALK Inhibitor
EML4 - ALK ALK T1151M Alectinib AZD3463 Brigatinib Crizotinib
ALK T1151R unknown
ALK T1343I unknown
ALK T429I unknown
ALK T535N unknown
ALK T680I no effect - predicted
ALK V1180L unknown
EML4 - ALK ALK V1180L ASP3026 Brigatinib Ceritinib Lorlatinib TAE684
ALK V1180X unknown
ALK V1180Y unknown
EML4 - ALK ALK V1180Y
ALK V1413G unknown
ALK V1545I no effect - predicted
ALK V163L unknown
ALK V198M unknown
ALK V476A no effect - predicted
ALK V66A unknown
ALK V66G unknown
ALK V757M unknown
ALK W501* loss of function - predicted
ALK wild-type no effect
ALK wild-type TP53 C176F
ALK wild-type TP53 H168R
ALK wild-type TP53 P177T
ALK wild-type TP53 mut
ALK wild-type TP53 wild-type
ALK Y1096A unknown
ALK Y1278A unknown
ALK Y1278E unknown
ALK Y1278S gain of function ALK Inhibitor
ALK Y1282E unknown