Gene Detail

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Gene Symbol ALK
Synonyms CD246 | NBLST3
Gene Description ALK, anaplastic lymphoma kinase, is a receptor in the insulin receptor superfamily and is a key regulator of neuronal development (PMID: 21502284) and also promotes cell proliferation through activation of MAPK and PI3K signaling pathways (PMID: 27573755). Alk activating mutations, rearrangements, and fusions have been identified in various cancers (PMID: 22649787), including EML4-ALK in non-small cell lung cancer (PMID: 30108712, PMID: 30194140), and a number of mutations confer resistance in the context of Alk fusions (PMID: 25749034, PMID: 21948233).

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Molecular Profile Protein Effect Treatment Approaches
ALK A1047T unknown
ALK A1200V no effect - predicted
ALK A1266D unknown
ALK A1266V no effect - predicted
ALK A195V no effect - predicted
ALK A348D gain of function ALK Inhibitor
ALK A585T no effect - predicted
ALK act mut gain of function ALK Inhibitor
ALK amp no effect
NPM1 - ALK ALK amp NPM1 amp
ALK amp ALK rearrange
ALK F1174V ALK amp
ALK F1174L ALK amp
ALK amp ALK pos
ALK C1156F unknown
NPM1 - ALK ALK C1156F Crizotinib
NPM1 - ALK ALK C1156F ALK D1203N
ALK C1156Y unknown
EML4 - ALK ALK C1156Y Alectinib Brigatinib Ensartinib Lorlatinib
ALK fusion ALK C1156Y
NPM1 - ALK ALK C1156Y
ALK C1156Y ALK rearrange
ALK C1156Y ALK L1198F ALK rearrange
EML4 - ALK ALK C1156Y ALK L1198F Crizotinib
EML4 - ALK ALK C1156Y ALK L1196M
EML4 - ALK ALK C1156Y ALK I1171T
EML4 - ALK ALK C1156Y ALK F1174C
EML4 - ALK ALK C1156Y ALK F1174I
EML4 - ALK ALK C1156Y ALK F1174V
EML4 - ALK ALK C1156Y ALK D1203N
EML4 - ALK ALK C1156Y ALK L1256F
EML4 - ALK ALK C1156Y ALK G1269A
ALK C1156Y ALK pos
EML4 - ALK ALK T1151M ALK C1156Y ALK F1174L ALK G1202R ALK S1206F ALK G1269A
EML4 - ALK ALK C1156Y ALK G1202R
ALK C990R unknown
ALK D1091N unknown
ALK D1203fs loss of function - predicted
ALK D1203N unknown
NPM1 - ALK ALK L1196M ALK D1203N ASP3026
EML4 - ALK ALK D1203N Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK F1174C ALK D1203N
EML4 - ALK ALK D1203N ALK E1210K Lorlatinib
ALK I1171N ALK D1203N ALK rearrange
ALK D1203N ALK E1210K ALK G1269A ALK rearrange
ALK D1203N ALK rearrange
EML4 - ALK ALK F1174L ALK D1203N ALK G1269A
ALK L1196M ALK D1203N ALK rearrange
EML4 - ALK ALK L1196M ALK D1203N
ALK D1249fs loss of function - predicted
ALK D1529E no effect - predicted
ALK D1529G unknown
ALK D94N unknown
ALK E1154K unknown
EML4 - ALK ALK E1154K ALK G1202R ALK I1268V
ALK E1210K unknown
NPM1 - ALK ALK E1210K Crizotinib
EML4 - ALK ALK E1210K Alectinib Brigatinib Ceritinib Lorlatinib
EML4 - ALK ALK S1206C ALK E1210K
ALK E1210K ALK rearrange
ALK E1303K unknown
EML4 - ALK ALK E1303K
ALK E717K unknown
ALK E862D unknown
ALK E994K no effect - predicted
ALK F1174C gain of function ALK Inhibitor
EML4 - ALK ALK F1174C Brigatinib Lorlatinib
EML4 - ALK ALK F1174C ALK L1198F Crizotinib
EML4 - ALK ALK F1174C ALK L1196M
EML4 - ALK ALK F1174C ALK G1269A
ALK F1174C ALK rearrange
ALK F1174C ALK G1202R ALK rearrange
ALK F1174I gain of function ALK Inhibitor
NPM1 - ALK ALK F1174I Alectinib Brigatinib Ceritinib Crizotinib Lorlatinib
ALK F1174L gain of function ALK Inhibitor
EML4 - ALK ALK F1174L Alectinib AZD3463 Lorlatinib
NPM1 - ALK ALK F1174L Brigatinib
ALK F1174L ALK L1198P
ALK G1123S ALK F1174L
ALK G1123D ALK F1174L
EML4 - ALK ALK F1174L ALK L1196M
EML4 - ALK ALK F1174L ALK L1198V
ALK F1174L ALK rearrange
EML4 - ALK ALK F1174L ALK G1269A
ALK F1174L ALK G1202R ALK rearrange
ALK F1174L ALK pos
EML4 - ALK ALK F1174L ALK G1202R
ALK F1174S gain of function ALK Inhibitor
ALK F1174V gain of function - predicted ALK Inhibitor
NPM1 - ALK ALK F1174V Brigatinib Ceritinib Crizotinib
NPM1 - ALK ALK F1174V ALK L1198F Crizotinib
EML4 - ALK ALK F1174V Alectinib Brigatinib
EML4 - ALK ALK I1171S ALK F1174V
EML4 - ALK ALK F1174V ALK G1202R
EML4 - ALK ALK F1174V ALK L1196M
ALK F1174V ALK pos
ALK F1174X unknown
ALK F1174X ALK rearrange
ALK F1245C gain of function ALK Inhibitor
EML4 - ALK ALK F1245C Ceritinib
ALK F1245I unknown
ALK F1245L unknown
ALK F1245Q unknown
ALK F1245V gain of function ALK Inhibitor
ALK F457L no effect - predicted
ALK F856S gain of function ALK Inhibitor
ALK fusion unknown ALK Inhibitor
ALK fusion SRC over exp
ALK fusion ALK T1151dup
ALK fusion ALK L1196M
ALK fusion ALK L1152R
ALK fusion ALK G1269A
ALK fusion ALK S1206Y
ALK fusion ALK G1202R
ALK fusion ALK G1202R KIT amp
ALK G1123D unknown
ALK G1123S unknown
ALK G1123S ALK rearrange
ALK G1128A gain of function ALK Inhibitor
ALK G1128S unknown
NPM1 - ALK ALK G1128S Brigatinib
ALK G1137R no effect - predicted
ALK G1201E gain of function ALK Inhibitor
ALK G1202del unknown
EML4 - ALK ALK G1202del Lorlatinib
ALK G1202del ALK rearrange
ALK G1202R unknown
EML4 - ALK ALK G1202R Brigatinib Lorlatinib
EML4 - ALK ALK L1198F ALK G1202R Crizotinib
ALK G1202R ALK rearrange
EML4 - ALK ALK L1196M ALK G1202R
ALK G1202R ALK G1269A ALK rearrange
ALK L1196M ALK G1202R ALK rearrange
ALK G1202R ALK L1204V ALK G1269A ALK rearrange
ALK V1180L ALK L1196M ALK G1202R ALK rearrange
NPM1 - ALK ALK G1202R
ALK T1151M ALK G1202R ALK rearrange
ALK G1202R ALK pos
EML4 - ALK ALK G1202R ALK G1269A
EML4 - ALK ALK G1202R ALK L1204V ALK G1269A
EML4 - ALK ALK L1198F ALK G1202R ALK G1269A
ALK G1202X unknown
ALK G1202X ALK rearrange
ALK G1269A unknown
EML4 - ALK ALK G1269A Alectinib AZD3463 Brigatinib Ceritinib Lorlatinib
NPM1 - ALK ALK G1269A ASP3026 AZD3463 Brigatinib
EML4 - ALK ALK L1198F ALK G1269A Brigatinib Crizotinib
EML4 - ALK ALK L1196M ALK G1269A
ALK T1151dup ALK G1269A ALK rearrange
EML4 - ALK ALK I1171T ALK G1269A
EML4 - ALK ALK I1171N ALK G1269A
ALK G1269A ALK rearrange
EML4 - ALK ALK I1171S ALK G1269A
ALK G1269E unknown
ALK G1269S gain of function - predicted ALK Inhibitor
EML4 - ALK ALK G1269S
ALK G1552R no effect - predicted
ALK G689V unknown
ALK G746C unknown
ALK G875R no effect - predicted
ALK G922R unknown
ALK H1030P unknown
ALK H354Q no effect - predicted
ALK I1171N gain of function ALK Inhibitor
NPM1 - ALK ALK I1171N
EML4 - ALK ALK I1171N Brigatinib Ceritinib Lorlatinib
ALK I1171N ALK rearrange
ALK I1171N ALK L1198F ALK rearrange
ALK I1171S unknown
EML4 - ALK ALK I1171S Lorlatinib
NPM1 - ALK ALK I1171S AZD3463 Brigatinib
EML4 - ALK ALK I1171S ALK L1196M
ALK I1171S ALK pos
ALK I1171T gain of function
NPM1 - ALK ALK I1171T
EML4 - ALK ALK I1171T Ceritinib Lorlatinib TAE684
ALK I1171T ALK rearrange
ALK I1171T ALK pos
ALK I1171X unknown
ALK I1171X ALK rearrange
ALK I1179V unknown
EML4 - ALK ALK I1179V ALK L1196M
ALK I1250T loss of function
ALK I1268V unknown
ALK I1461V unknown
ALK inact mut loss of function
ALK K1062M gain of function ALK Inhibitor
ALK K1491R no effect - predicted
ALK K894T unknown
NPM1 - ALK ALK L1122V
ALK L1122V unknown
NPM1 - ALK ALK L1122V ALK L1196M
ALK L1152P unknown
EML4 - ALK ALK L1152P Brigatinib
ALK L1152R unknown
EML4 - ALK ALK L1152R Brigatinib Lorlatinib
ALK L1152R ALK rearrange
NPM1 - ALK ALK L1152R
ALK L1152R ALK pos
ALK L1152V unknown
ALK L1152V ALK pos
ALK L1196M gain of function - predicted ALK Inhibitor
EML4 - ALK ALK L1196M Brigatinib Ceritinib Ensartinib Entrectinib Lorlatinib Repotrectinib
NPM1 - ALK ALK L1196M Brigatinib Ceritinib
ALK L1196M ALK S1206C
EML4 - ALK ALK L1196M ALK L1198F
ALK L1196M ALK rearrange
EML4 - ALK ALK L1196M ALK L1198H
EML4 - ALK ALK L1196M ALK L1256F
ALK L1196M ALK pos
ALK L1196Q gain of function - predicted ALK Inhibitor
NPM1 - ALK ALK L1196Q ASP3026
ALK L1196X unknown
ALK L1196X ALK rearrange
ALK L1198F ALK mut ALK rearrange
ALK L1198F gain of function ALK Inhibitor
NPM1 - ALK ALK L1198F Crizotinib
EML4 - ALK ALK L1198F Brigatinib Crizotinib
ALK L1198F ALK rearrange
ALK L1198H unknown
ALK L1198P gain of function - predicted ALK Inhibitor
EML4 - ALK ALK L1198P
ALK L1198V unknown
ALK L1198X unknown
ALK L1204V unknown
ALK L1256F unknown
EML4 - ALK ALK L1256F
ALK L560F no effect - predicted
ALK L868Q unknown
ALK M1166R gain of function ALK Inhibitor
ALK M1166V unknown
ALK M1478T unknown
ALK M301I no effect - predicted
ALK M552I no effect - predicted
ALK mutant unknown
ALK mut ALK rearrange
ALK N1178H unknown
NPM1 - ALK ALK N1178H Alectinib Crizotinib
ALK neg ROS1 pos
ALK negative loss of function
ALK neg ROS1 rearrange
ALK over exp no effect
ALK P1112Q unknown
NPM1 - ALK ALK P1139S Alectinib ASP3026 Brigatinib Crizotinib
ALK P1139S unknown
ALK P1298S unknown
ALK P1543S unknown
ALK P1599S unknown
ALK P336S no effect - predicted
ALK P36S unknown
ALK P40L unknown
ALK P858S no effect - predicted
ALK positive unknown
ALK R1113Q unknown
ALK R1192P gain of function ALK Inhibitor
EML4 - ALK ALK R1192P Alectinib AZD3463 Brigatinib Crizotinib
NPM1 - ALK ALK R1192P Brigatinib
ALK R1209Q loss of function - predicted
ALK R1212H unknown
ALK R1275L unknown
ALK R1275Q gain of function ALK Inhibitor
ALK R133H no effect - predicted
ALK R284K unknown
ALK R291C unknown
ALK R311H unknown
ALK R395H unknown
ALK R401* loss of function - predicted
ALK R401Q no effect - predicted
ALK R753Q unknown
ALK rearrange unknown ALK Inhibitor
ALK rearrange MAP2K1 K57N
ALK rearrange SRC pos
ALK S1206Y ALK rearrange
ALK V1180L ALK rearrange
ALK V1180X ALK rearrange
ALK S1053F unknown
ALK S1206C unknown
NPM1 - ALK ALK S1206C
ALK S1206F unknown
EML4 - ALK ALK S1206F Brigatinib
ALK S1206Y unknown
EML4 - ALK ALK S1206Y Brigatinib Ceritinib Lorlatinib
NPM1 - ALK ALK S1206Y
ALK S529Y no effect - predicted
ALK S711R no effect - predicted
ALK S865P no effect - predicted
ALK T1151dup unknown
EML4 - ALK ALK T1151dup Brigatinib
ALK T1151M unknown
EML4 - ALK ALK T1151M Alectinib AZD3463 Brigatinib Crizotinib
NPM1 - ALK ALK T1151M
ALK T429I unknown
ALK T680I no effect - predicted
ALK V1180L unknown
EML4 - ALK ALK V1180L ASP3026 Brigatinib Ceritinib Lorlatinib TAE684
ALK V1180X unknown
ALK V1413G unknown
ALK V1545I no effect - predicted
ALK V163L unknown
ALK V198M unknown
ALK V476A no effect - predicted
ALK V66A unknown
ALK V66G unknown
ALK W501* loss of function - predicted
ALK wild-type no effect
ALK Y1278S gain of function ALK Inhibitor