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Gene Symbol FLT3
Synonyms CD135 | FLK-2 | FLK2 | STK1
Gene Description FLT3, fms related receptor tyrosine kinase 3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385, PMID: 32241850).

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Molecular Profile Protein Effect Treatment Approaches
FLT3 A450E unknown
FLT3 A627P unknown
FLT3 exon 14 ins FLT3 A627P
FLT3 A627T unknown
FLT3 A680fs loss of function - predicted
FLT3 A680V gain of function - predicted FLT3 Inhibitor
FLT3 A814S unknown
FLT3 A848P gain of function - predicted
FLT3 exon 14 ins FLT3 A848P
FLT3 A914D unknown
FLT3 act mut gain of function FLT3 Inhibitor
FLT3 amp no effect FLT3 Inhibitor
FLT3 C184* loss of function - predicted
FLT3 C695S unknown
FLT3 D200N no effect - predicted
FLT3 D200N FLT3 D835Y
FLT3 D324N no effect - predicted
FLT3 D358V unknown
FLT3 D593_D600dup gain of function - predicted FLT3 Inhibitor
FLT3 D698N unknown
FLT3 exon 14 ins FLT3 D698N
FLT3 exon 14 ins FLT3 F691L FLT3 D698N
FLT3 D750Y unknown
FLT3 D7G unknown
FLT3 D835A gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835A
FLT3 D835del gain of function FLT3 Inhibitor
FLT3 D835E gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835E
FLT3 exon 14 ins FLT3 F691L FLT3 D835E
FLT3 D835F unknown
FLT3 exon 14 ins FLT3 D835F
FLT3 D835G gain of function - predicted FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835G
FLT3 exon 14 ins FLT3 F691L FLT3 D835G
FLT3 D835H gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835H
FLT3 exon 14 ins FLT3 F691L FLT3 D835H
FLT3 D835I unknown
FLT3 exon 14 ins FLT3 D835I
FLT3 D835N gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835N
FLT3 exon 14 ins FLT3 F691L FLT3 D835N
FLT3 D835V gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835V
FLT3 D835X unknown FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835X
FLT3 D835Y gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 D835Y
FLT3 exon 14 ins FLT3 F691L FLT3 D835Y
FLT3 N676D FLT3 D835Y
FLT3 F691L FLT3 D835Y
FLT3 L601F FLT3 D835Y
FLT3 D835Y PTPN11 A72D
FLT3 D835Y IDH1 wild-type
FLT3 D835Y IDH1 R132H
FLT3 D839A unknown
FLT3 exon 14 ins FLT3 D839A
FLT3 exon 14 ins FLT3 F691L FLT3 D839A
FLT3 D839G gain of function FLT3 Inhibitor
FLT3 exon 14 ins FLT3 F691L FLT3 D839G
FLT3 exon 14 ins FLT3 D839G
FLT3 D839H unknown
FLT3 exon 14 ins FLT3 D839H
FLT3 exon 14 ins FLT3 M837G FLT3 S838R FLT3 D839H
FLT3 D839N unknown
FLT3 exon 14 ins FLT3 D839N
FLT3 exon 14 ins FLT3 F691L FLT3 D839N
FLT3 D870E unknown
FLT3 D895Y unknown
FLT3 E140* loss of function - predicted
FLT3 E236* loss of function - predicted
FLT3 E366* loss of function - predicted
FLT3 E366D unknown
FLT3 E415K unknown
FLT3 E598_Y599insDVDFREYE gain of function - predicted FLT3 Inhibitor
FLT3 E598_Y599insFDFREYE gain of function - predicted
FLT3 E598_Y599insFDFREYE FLT3 R845G
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE gain of function FLT3 Inhibitor
FLT3 E608fs loss of function - predicted
FLT3 E611fs loss of function - predicted
FLT3 E654D unknown
FLT3 exon 14 ins FLT3 E654D
FLT3 E708G unknown
FLT3 E77K unknown
FLT3 E880K unknown
FLT3 E964A unknown
FLT3 exon 14 ins gain of function - predicted FLT3 Inhibitor
FLT3 exon 14 ins FLT3 F691L
FLT3 exon 14 ins FLT3 Y842H
FLT3 exon 14 ins FLT3 Y842C
FLT3 exon 14 ins FLT3 R834Q
FLT3 exon 14 ins FLT3 F691L FLT3 R834Q
FLT3 exon 14 ins FLT3 F691L FLT3 Y842C
FLT3 exon 14 ins FLT3 F691L FLT3 Y842H
FLT3 exon 14 ins FLT3 G846R
FLT3 exon 14 ins FLT3 F691L FLT3 G846R
FLT3 exon 14 ins FLT3 M664I
FLT3 exon 14 ins FLT3 M664I FLT3 F691L
FLT3 exon 14 ins FLT3 N676S
FLT3 exon 14 ins FLT3 N676S FLT3 F691L
FLT3 exon 14 ins FLT3 N841K
FLT3 exon 14 ins FLT3 F691L FLT3 N841K
FLT3 exon 14 ins FLT3 R845G
FLT3 exon 14 ins FLT3 F691L FLT3 R845G
FLT3 exon 14 ins FLT3 T820A
FLT3 exon 14 ins FLT3 Y842S
FLT3 exon 14 ins FLT3 F691L FLT3 Y842S
FLT3 exon 14 ins FLT3 S652G
FLT3 exon 14 ins FLT3 N676D FLT3 Y842C
FLT3 exon 14 ins NPM1 mut
FLT3 exon 14 ins FLT3 F691I
FLT3 exon 14 ins FLT3 N676D
FLT3 exon 14 ins FLT3 F621L
DNMT3A mut FLT3 exon 14 ins NPM1 mut
FLT3 exon 14 ins NPM1 wild-type
FLT3 exon 14 ins FLT3 LOH
FLT3 exon 14 ins FLT3 G697R
FLT3 exon 14 ins FLT3 Y842R
FLT3 exon 14 ins FLT3 N676T
FLT3 exon14 unknown
FLT3 exon15 unknown
FLT3 exon16 unknown
FLT3 exon17 unknown
FLT3 exon18 unknown
FLT3 exon19 unknown
FLT3 exon20 unknown
FLT3 exon21 unknown
FLT3 exon22 unknown
FLT3 exon23 unknown
FLT3 F406C unknown
FLT3 F590G unknown
FLT3 F590_F605dup gain of function FLT3 Inhibitor
FLT3 F590_Y591delinsGD gain of function FLT3 Inhibitor
FLT3 F594C gain of function - predicted FLT3 Inhibitor
FLT3 F594L gain of function FLT3 Inhibitor
FLT3 F594Y gain of function - predicted FLT3 Inhibitor
FLT3 F594_D600dup gain of function - predicted FLT3 Inhibitor
FLT3 F612fs loss of function - predicted
FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLEF gain of function - predicted FLT3 Inhibitor
FLT3 F621L unknown
FLT3 F691I unknown
FLT3 F691L no effect - predicted
FLT3 F804C unknown
FLT3 fusion unknown
FLT3 G282R unknown
FLT3 G617E unknown
FLT3 G619V unknown
FLT3 G697R unknown
FLT3 G822R unknown
FLT3 G831E unknown
FLT3 G846R unknown
FLT3 G905V unknown
FLT3 H821fs unknown
FLT3 I38V unknown
FLT3 I417L unknown
FLT3 I836del gain of function FLT3 Inhibitor
FLT3 I836F unknown
FLT3 I836H unknown
FLT3 I836M unknown
FLT3 I836V unknown
FLT3 I836X unknown
FLT3 I836_M837del unknown
FLT3 I836_M837insIRC unknown
FLT3 I867S gain of function FLT3 Inhibitor
FLT3 inact mut loss of function
FLT3 K290T unknown
FLT3 K429E gain of function - predicted
FLT3 K438fs loss of function - predicted
FLT3 K826fs unknown
FLT3 K868N loss of function
FLT3 L37S unknown
FLT3 L576R gain of function FLT3 Inhibitor
FLT3 L601F no effect - predicted
FLT3 L610fs loss of function - predicted
FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL gain of function FLT3 Inhibitor
FLT3 L678M unknown
FLT3 L699F unknown
FLT3 L832F unknown
FLT3 L850fs unknown
FLT3 LOH unknown
FLT3 M664I unknown
FLT3 M737I no effect - predicted
FLT3 M837G unknown
FLT3 M837P unknown
FLT3 mutant unknown
DNMT3A mut FLT3 mut NPM1 mut
DNMT3A wild-type FLT3 mut NPM1 mut
FLT3 N587fs loss of function - predicted
FLT3 N609fs loss of function - predicted
FLT3 N609K unknown
FLT3 N676D unknown
FLT3 N676K gain of function FLT3 Inhibitor
FLT3 N676S unknown
FLT3 N676T unknown
FLT3 N841I gain of function FLT3 Inhibitor
FLT3 N841K unknown
FLT3 N841Y unknown
FLT3 N847fs unknown
FLT3 over exp no effect FLT3 Inhibitor
FLT3 P532S unknown
FLT3 P54L unknown
FLT3 P606L unknown
FLT3 P733Q unknown
FLT3 P738R unknown
FLT3 P888S unknown
FLT3 P893L unknown
FLT3 P986L unknown
FLT3 positive unknown
CBL Y371del FLT3 pos
CBL Y371H FLT3 pos
CBL Q365_E366insSK FLT3 pos
FLT3 R174K unknown
FLT3 R387Q unknown
FLT3 R595_L601dup gain of function FLT3 Inhibitor
FLT3 R607fs loss of function - predicted
FLT3 R834Q gain of function FLT3 Inhibitor
FLT3 R845G unknown
FLT3 R849fs unknown
FLT3 R933L unknown
FLT3 rearrange unknown
FLT3 S127F unknown
FLT3 S451E unknown
FLT3 S451F gain of function FLT3 Inhibitor
FLT3 S454L unknown
FLT3 S585_F594dup gain of function - predicted FLT3 Inhibitor
FLT3 S618L unknown
FLT3 S652G unknown
FLT3 S71I unknown
FLT3 S838R unknown
FLT3 S840_N841insGS gain of function FLT3 Inhibitor
FLT3 S985fs unknown
FLT3 T136N unknown
FLT3 T167A no effect - predicted
FLT3 T227M unknown
FLT3 T628I unknown
FLT3 T820A unknown
FLT3 V194M no effect - predicted
FLT3 V197A unknown
FLT3 V220G unknown
FLT3 V557A unknown
FLT3 V557I unknown
FLT3 V579A gain of function FLT3 Inhibitor
FLT3 V579fs loss of function - predicted
FLT3 V581* loss of function - predicted
FLT3 V581fs loss of function - predicted
FLT3 V592A gain of function FLT3 Inhibitor
FLT3 V592G gain of function FLT3 Inhibitor
FLT3 V637I unknown
FLT3 V819I unknown
FLT3 V824fs unknown
FLT3 V825* unknown
FLT3 V843A unknown
FLT3 W603_E604insDREYEYDLKW gain of function - predicted FLT3 Inhibitor
FLT3 wild-type no effect
FLT3 wild-type NPM1 mut
CBL Q365_E366insSK FLT3 wild-type
CBL Y371H FLT3 wild-type
FLT3 wild-type NPM1 wild-type
FLT3 Y364H no effect - predicted
FLT3 Y457C unknown
FLT3 Y572C gain of function FLT3 Inhibitor
FLT3 Y591D unknown
FLT3 Y597_K602dup gain of function - predicted FLT3 Inhibitor
FLT3 Y599F loss of function
FLT3 Y599_D600insEYEYEYEY gain of function - predicted FLT3 Inhibitor
FLT3 Y599_D600insGLYVDFREYEY gain of function - predicted FLT3 Inhibitor
FLT3 Y599_D600insPAPQIMSTSTLISENMNIA gain of function - predicted FLT3 Inhibitor
FLT3 Y599_D600insSTDNEYFYVDFREYEY gain of function - predicted FLT3 Inhibitor
DNMT3A R882H FLT3 Y599_D600insSTDNEYFYVDFREYEY NPM1 W288fs
FLT3 Y599_D600insSTDNEYFYVDFREYEY IDH2 R140W
FLT3 Y842C gain of function FLT3 Inhibitor
FLT3 Y842H gain of function FLT3 Inhibitor
FLT3 Y842R unknown
FLT3 Y842S unknown