Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Ramucirumab ovary epithelial cancer not applicable detail...
Unknown unknown Bevacizumab + Niraparib ovary epithelial cancer not applicable detail...
Unknown unknown Bevacizumab + Carboplatin + Paclitaxel ovary epithelial cancer not applicable detail...
Unknown unknown Binimetinib + Paclitaxel ovary epithelial cancer not applicable detail...
KRAS G12D Binimetinib + Paclitaxel ovary epithelial cancer predicted - sensitive detail...
KRAS G12V Binimetinib + Paclitaxel ovary epithelial cancer predicted - sensitive detail...
Unknown unknown Afuresertib + Carboplatin + Paclitaxel ovary epithelial cancer not applicable detail...
Unknown unknown Alpelisib + Olaparib ovary epithelial cancer not applicable detail...
BRCA1 wild-type BRCA2 wild-type Alpelisib + Olaparib ovary epithelial cancer predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00703105 Phase II Denileukin diftitox Ovarian Dendritic Cell Vaccine Trial Recruiting
NCT01012817 Phase Ib/II Topotecan + Veliparib Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer Active, not recruiting
NCT01116648 Phase Ib/II Olaparib Cediranib + Olaparib Cediranib Maleate and Olaparib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer Active, not recruiting
NCT01145430 Phase I Pegylated liposomal-doxorubicin + Veliparib Veliparib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer or Metastatic Breast Cancer Completed
NCT01146795 Phase II Bevacizumab + Carboplatin + Paclitaxel Neoadjuvant Therapy for Ovarian Cancer Terminated
NCT01239732 Phase III Bevacizumab + Carboplatin + Paclitaxel A Study of the Addition of Avastin (Bevacizumab) to Carboplatin and Paclitaxel Therapy in Patients With Ovarian Cancer Completed
NCT01519869 Phase I Trial of Chemotherapy in Ovarian, Fallopian Tube and Peritoneal Carcinoma Active, not recruiting
NCT01535157 Phase Ib/II Ketoconazole Fenretinide Fenretinide/LXS Oral Powder Plus Ketoconazole in Recurrent Ovarian Cancer Active, not recruiting
NCT01536743 Phase II Palbociclib A Open Label Study of the Efficacy and Safety of PD0332991 a Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-proficiency and Low p16 Expression Active, not recruiting
NCT01649336 Phase I Binimetinib + Paclitaxel A Study of MEK162 and Paclitaxel in Patients With Epithelial Ovarian, Fallopian Tube or Peritoneal Cancer Completed
NCT01690468 Phase Ib/II Carboplatin + Triciribine PTX-200 and Carboplatin in Ovarian Cancer Recruiting
NCT01749397 Phase I Floxuridine + Veliparib Veliparib and Floxuridine in Treating Patients With Metastatic Epithelial Ovarian, Primary Peritoneal Cavity, or Fallopian Tube Cancer Active, not recruiting
NCT01846611 Phase III Pegylated liposomal-doxorubicin Dexamethasone A Study Comparing the Combination of Trabectedin (YONDELIS) and DOXIL/CAELYX With DOXIL/CAELYX for the Treatment of Advanced-Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Completed
NCT01853644 Phase II Tivozanib Tivozanib in Recurrent, Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer Active, not recruiting
NCT01891344 Phase II Rucaparib A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2) Active, not recruiting
NCT01968213 Phase III Rucaparib A Study of Rucaparib as Switch Maintenance Following Platinum-Based Chemotherapy in Patients With Platinum-Sensitive, High-Grade Serous or Endometrioid Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer Active, not recruiting
NCT01991210 Phase II DNIB0600A Pegylated liposomal-doxorubicin A Randomized Study of DNIB0600A in Comparison With Pegylated Liposomal Doxorubicin in Patients With Platinum-Resistant Ovarian Cancer Terminated
NCT02033616 Phase II Ovapuldencel-T Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Advanced Epithelial Ovarian Carcinomas Recruiting
NCT02091999 Phase I Enfortumab vedotin A Study of Escalating Doses of ASG-22CE Given as Monotherapy in Subjects With Metastatic Urothelial Cancer and Other Malignant Solid Tumors That Express Nectin-4 Recruiting
NCT02187848 Phase Ib/II SAR408701 Evaluation of SAR408701 in Patients With Advanced Solid Tumors Recruiting
NCT02188550 Phase II Everolimus + Letrozole Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status
NCT02195973 Phase Ib/II Paclitaxel + Sonidegib Phase IB/II Trial of LDE225 and Paclitaxel in Recurrent Ovarian Cancer Completed
NCT02275039 Phase I MVAp53 Gemcitabine p53MVA Vaccine and Gemcitabine Hydrochloride in Treating Patients With Recurrent Ovarian Epithelial Cancer Completed
NCT02278783 Phase II Regorafenib Phase 2 Trial of Regorafenib in Patients With Recurrent Ovarian, Primary Peritoneal and Fallopian Tube Cancer Terminated
NCT02289950 Phase II Farletuzumab A Study to Assess the Efficacy and Safety of Farletuzumab (MORAb 003) in Combination With Carboplatin Plus Paclitaxel or Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Subjects With Low CA125 Platinum-Sensitive Ovarian Cancer Active, not recruiting
NCT02354131 Phase Ib/II Niraparib Bevacizumab + Niraparib Niraparib Versus Niraparib-bevacizumab Combination in Women With Platinum-sensitive Epithelial Ovarian Cancer (AVANOVA) Active, not recruiting
NCT02392676 Phase III Olaparib Olaparib Maintenance Treatment Versus Placebo in Patients With PSR Ovarian Cancer Who Are in CR or PR to Platinum-based Chemotherapy and Whose Tumours Carry sBRCAm or HRR-associated Genes Mutations Withdrawn
NCT02534922 Phase I Prolanta Study of Prolanta in Recurrent or Persistent Epithelial Ovarian Cancer (ProlantaOC) Recruiting
NCT02537444 Phase II Acalabrutinib Pembrolizumab ACP-196 Alone and in Combination With Pembrolizumab in Subjects With Recurrent Ovarian Cancer (KEYNOTE191) Unknown status
NCT02539719 Phase I ABBV-181 + SC-003 SC-003 Study of SC-003 Alone and in Combination With ABBV-181 in Subjects With Platinum-Resistant/Refractory Ovarian Cancer Terminated
NCT02540356 Phase Ib/II Imalumab Phase 1/2a Two-Arm Dose-Escalation Study of BAX69 in Subjects With Malignant Ascites of Ovarian Cancer Terminated
NCT02644369 Phase II Pembrolizumab Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors (INSPIRE) Active, not recruiting
NCT02660034 Phase I BGB-A317 + Pamiparib The Safety, Pharmacokinetics and Antitumor Activity of BGB-A317 in Combination With BGB-290 in Subjects With Advanced Solid Tumors Recruiting
NCT02674061 Phase II Pembrolizumab Efficacy and Safety Study of Pembrolizumab (MK-3475) in Women With Advanced Recurrent Ovarian Cancer (MK-3475-100/KEYNOTE-100) Active, not recruiting
NCT02713386 Phase Ib/II Ruxolitinib Carboplatin + Paclitaxel Ruxolitinib Phosphate, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting
NCT02718417 Phase III Avelumab Carboplatin + Paclitaxel Avelumab in Previously Untreated Patients With Epithelial Ovarian Cancer (JAVELIN OVARIAN 100) Terminated
NCT02726997 Phase Ib/II Carboplatin + Durvalumab + Paclitaxel Matched Paired Pharmacodynamics and Feasibility Study of Durvalumab in Combination With Chemotherapy in Frontline Ovarian Cancer Recruiting
NCT02728830 Phase I Pembrolizumab A Study of Pembrolizumab on the Tumoral Immunoprofile of Gynecologic Cancers Active, not recruiting
NCT02766582 Phase II Carboplatin + Paclitaxel + Pembrolizumab Phase II: Pembrolizumab/Carboplatin/Taxol in Epithelial Ovary Cancer Recruiting
NCT02785250 Phase I Cyclophosphamide + DPX-Survivac + Epacadostat Study of DPX-Survivac Vaccine Therapy and Epacadostat in Patients With Recurrent Ovarian Cancer Recruiting
NCT02788708 Phase I Lenvatinib + Paclitaxel Lenvatinib and Weekly Paclitaxel for Patients With Recurrent Endometrial or Ovarian Cancer Active, not recruiting
NCT02811497 Phase II Azacitidine + Durvalumab Study of Azacitidine and Durvalumab in Advanced Solid Tumors (METADUR) Recruiting
NCT02824042 Phase I Anetumab ravtansine + Itraconazole Anetumab ravtansine Thorough ECG (Electrocardiogram) and Drug Interaction Study With Anetumab Ravtansine and Itraconazole Active, not recruiting
NCT02833506 Phase I NY-ESO-1 peptide vaccine + Sirolimus NY-ESO-1 peptide vaccine Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Withdrawn
NCT02834975 Phase II Carboplatin + Paclitaxel + Pembrolizumab Pembrolizumab, Paclitaxel, and Carboplatin in Patients With Advanced Stage Epithelial Ovarian Cancer (EOC). Recruiting
NCT02853318 Phase II Bevacizumab + Cyclophosphamide + Pembrolizumab Pembrolizumab, Bevacizumab, and Cyclophosphamide in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Active, not recruiting
NCT02855944 Phase III Cisplatin Rucaparib Carboplatin Gemcitabine Paclitaxel ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients Recruiting
NCT02865811 Phase II Pegylated liposomal-doxorubicin + Pembrolizumab Pembrolizumab Combined With PLD For Recurrent Platinum Resistant Ovarian, Fallopian Tube Or Peritoneal Cancer Active, not recruiting
NCT02873962 Phase II Bevacizumab + Nivolumab A Phase II Study Of Nivolumab/ Bevacizumab Recruiting
NCT02884648 Phase II Bevacizumab Bevacizumab in Ovarian Cancer Patients With Disease at Second-look Surgery Recruiting
NCT02900560 Phase II Azacitidine + Pembrolizumab Study of Pembrolizumab With or Without CC-486 in Patients With Platinum-resistant Ovarian Cancer Recruiting
NCT02901899 Phase II Guadecitabine + Pembrolizumab Guadecitabine and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Recruiting
NCT02915523 Phase Ib/II Avelumab Avelumab + Entinostat Phase 1b/2 Study of Avelumab With or Without Entinostat in Patients With Advanced Epithelial Ovarian Cancer Active, not recruiting
NCT02922764 Phase I RGX-104 Nivolumab + RGX-104 A Study of RGX-104 With or Without Nivolumab in Patients With Advanced Solid Malignancies and Lymphoma Recruiting
NCT02923739 Phase II Bevacizumab + Emactuzumab + Paclitaxel Bevacizumab + Paclitaxel Induction Discontinuation Trial of Emactuzumab Following Paclitaxel and Bevacizumab in Patients With Platinum-Resistant, Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer - REDIRECT Active, not recruiting
NCT02943317 Phase I Defactinib Avelumab Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Activity of Defactinib in Combination With Avelumab in Epithelial Ovarian Cancer Terminated
NCT02948101 Phase II Cyclophosphamide + PD 0360324 Pre-Conditioning Effects of Anti-Macrophage Therapy Using PD 0360324 in Recurrent Platinum-Resistant Epithelial Ovarian Cancer Withdrawn
NCT02948426 Phase I interferon gamma + peginterferon alfa-2b Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer Recruiting
NCT02953457 Phase Ib/II Durvalumab + Olaparib + Tremelimumab Olaparib, Durvalumab, and Tremelimumab in Treating Patients With Recurrent or Refractory Ovarian, Fallopian Tube or Primary Peritoneal Cancer With BRCA1 or BRAC2 Mutation Recruiting
NCT02963831 Phase Ib/II Durvalumab + ONCOS-102 A Phase 1/2 Study to Investigate the Safety, Biologic and Anti-tumor Activity of ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies Recruiting
NCT03018405 Phase I NKR-2 cells A Dose Escalation Phase I Study to Assess the Safety and Clinical Activity of Multiple Cancer Indications (THINK) Recruiting
NCT03038100 Phase III Atezolizumab + Bevacizumab + Carboplatin + Paclitaxel Bevacizumab + Carboplatin + Paclitaxel A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (IMagyn050) Active, not recruiting
NCT03054909 Phase I ALT-803 QUILT-2.021: Phase I of IP Followed by SQ ALT-803 for Ovarian Cancer Recruiting
NCT03078400 Phase I SPL-108 Safety and Efficacy Study of Daily SPL-108 Injections In Conjunction With Paclitaxel in Women With Ovarian Cancer Recruiting
NCT03079687 Expanded access Olaparib Expanded Access Program for Olaparib Tablets as Maintenance Therapy in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Cancer. Approved for marketing
NCT03081702 Phase Ib/II Hydroxychloroquine + Itraconazole A Study of the Safety, Tolerability and Effectiveness of Hydroxychloroquine and Itraconazole in Platinum-resistant Epithelial Ovarian Cancer Recruiting
NCT03093155 Phase II Bevacizumab + Ixabepilone Ixabepilone Evaluation of Weekly Ixabepilone With or Without Biweekly Bevacizumab Recruiting
NCT03106987 Phase III Olaparib A Study to Examine Olaparib Maintenance Retreatment in Patients With Epithelial Ovarian Cancer. (OReO) Recruiting
NCT03113487 Phase II MVAp53 + Pembrolizumab P53MVA and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Recruiting
NCT03138408 Phase I SC-004 ABBV-181 + SC-004 SC-004 Alone or With ABBV-181 in Subjects With Epithelial Ovarian, Fallopian Tube, Primary Peritoneal and Endometrial Cancers Terminated
NCT03162562 Phase I Oregovomab + Poly ICLC The Safety and Antitumor Activity of the Combination of Oregovomab and Hiltonol in Recurrent Advanced Ovarian Cancer Active, not recruiting
NCT03206047 Phase Ib/II Atezolizumab + Guadecitabine Atezolizumab Atezolizumab + DEC-205-NY-ESO-1 fusion protein vaccine + Guadecitabine Atezolizumab, Guadecitabine, and CDX-1401 Vaccine in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Suspended
NCT03206645 Phase I Carboplatin + Paclitaxel + PTC596 PTC-596 in Women With Ovarian Cancer Receiving Neoadjuvant Chemotherapy Recruiting
NCT03213964 Phase I Aldesleukin + FATE-NK100 Intraperitoneal Delivery of Adaptive Natural Killer (NK) Cells (FATE-NK100) With Intraperitoneal Int Recruiting
NCT03245892 Phase I Carboplatin + Nivolumab + Paclitaxel A Study of Carboplatin and Paclitaxel Chemotherapy With Nivolumab in Patients With Ovarian Cancer Active, not recruiting
NCT03246074 Phase I Fostamatinib + Paclitaxel Clinical Trial of Combined Fostamatinib and Paclitaxel in Ovarian Cancer Recruiting
NCT03287271 Phase Ib/II Defactinib ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK Recruiting
NCT03312114 Phase II Avelumab Anti—PD-L1 and SAbR for Ovarian Cancer Active, not recruiting
NCT03318900 Phase I Aldesleukin + Cyclophosphamide + Utomilumab T Cell Immunotherapy for Advanced Ovarian Cancer Recruiting
NCT03319628 Phase I XMT-1536 First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b Recruiting
NCT03326193 Phase II Bevacizumab + Niraparib Phase 2, A Study of Niraparib Combined With Bevacizumab Maintenance Treatment in Patients With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy Active, not recruiting
NCT03394885 Phase Ib/II Atezolizumab + Carboplatin + Paclitaxel Atezolizumab With Neoadjuvant Chemotherapy for Patients With Newly-Diagnosed Advanced-Stage Ovarian Cancer (AdORN) Recruiting
NCT03430518 Phase I Durvalumab + Eribulin Durvalumab and Eribulin in Her2-negative Metastatic Breast Cancer and Recurrent Ovarian Cancer Active, not recruiting
NCT03519178 Phase II PF-06873600 A Safety, Pharmacokinetic, Pharmacodynamic and Anti-Tumor Study of PF-06873600 as a Single Agent and in Combination With Endocrine Therapy Recruiting
NCT03522246 Phase III Rucaparib Nivolumab Nivolumab + Rucaparib A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy (ATHENA) Recruiting
NCT03558139 Phase I Avelumab + Hu5F9-G4 A Trial of Hu5F9-G4 With Avelumab in Ovarian Cancer Recruiting
NCT03564340 Phase Ib/II Cemiplimab + REGN4018 REGN4018 Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Patients With Platinum-Resistant Ovarian Cancer Recruiting
NCT03574779 Phase II Bevacizumab + Niraparib + TSR-042 Phase 2 Multicohort Study to Evaluate the Safety and Efficacy of Novel Treatment Combinations in Patients With Recurrent Ovarian Cancer (OPAL) Recruiting
NCT03579316 Phase II Olaparib Adavosertib + Olaparib Adavosertib With or Without Olaparib in Treating Participants With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Recruiting
NCT03637764 Phase Ib/II Atezolizumab + Isatuximab Isatuximab Safety, Preliminary Efficacy and PK of Isatuximab (SAR650984) Alone or in Combination With Atezolizumab in Patients With Advanced Malignancies Recruiting
NCT03642132 Phase III Bevacizumab + Carboplatin + Paclitaxel Carboplatin + Paclitaxel + Talazoparib Avelumab + Carboplatin + Paclitaxel + Talazoparib Avelumab and Talazoparib in Untreated Advanced Ovarian Cancer (JAVELIN OVARIAN PARP 100) Active, not recruiting
NCT03657043 Phase II Tisotumab Vedotin A Study of Tisotumab Vedotin for Patients With Platinum-Resistant Ovarian Cancer With a Safety Run-in of a Dose-Dense Regimen (innovaTV 208) Recruiting
NCT03704467 Phase II Bevacizumab + Carboplatin + Gemcitabine + Paclitaxel + Pegylated liposomal-doxorubicin Avelumab + Carboplatin + VX-970 Study of Avelumab + M6620 + Carboplatin in Poly (Adenosine Diphosphate Ribose [ADP]-Ribose) Polymerase Inhibitor (PARPi)-Resistant Recurrent Ovarian Cancer Recruiting
NCT03732950 Phase II Pembrolizumab Pembrolizumab in Treating Participants With Recurrent Ovarian Cancer Not yet recruiting
NCT03734692 Phase Ib/II Cisplatin + Pembrolizumab + Rintatolimod Systemic Immune Checkpoint Blockade and Intraperitoneal Chemo-Immunotherapy in Recurrent Ovarian Cancer Recruiting
NCT03740165 Phase III Bevacizumab + Carboplatin + Paclitaxel Carboplatin + Paclitaxel Carboplatin + Paclitaxel + Pembrolizumab Bevacizumab + Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Carboplatin + Olaparib + Paclitaxel + Pembrolizumab Bevacizumab + Carboplatin + Paclitaxel + Pembrolizumab Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/ENGOT-ov43/KEYLYNK-001) Recruiting
NCT03748186 Phase I STRO-002 Study of STRO-002, an Anti-Folate Receptor Alpha (FolR?) Antibody Drug Conjugate in Ovarian & Endometrial Cancers Recruiting
NCT03756818 Phase I Paclitaxel + TAK-659 TAK-659 and Paclitaxel in Treating Patients With Advanced Solid Tumors Recruiting
NCT03784677 Phase I SOR-C13 SOR-C13 in Treating Patients With Advanced Refractory Solid Tumors Not yet recruiting
NCT03824704 Phase II Nivolumab + Rucaparib A Study to Evaluate Rucaparib in Combination With Nivolumab in Patients With Selected Solid Tumors (ARIES) Recruiting
NCT03836352 Phase II DPX-Survivac + Pembrolizumab Cyclophosphamide + DPX-Survivac + Pembrolizumab Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors Recruiting
NCT03861403 Phase Ib/II Avelumab + Cyclophosphamide + TRX518 A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid Tumors Recruiting
NCT03934814 Phase I TJ011133 Pembrolizumab + TJ011133 Rituximab + TJ011133 Study of TJ011133 Subjects With Relapsed/Refractory Advanced Solid Tumors and Lymphoma Recruiting
NCT03943173 Phase I Olaparib Olaparib in Treating Patients With Newly Diagnosed BRCA-Mutant Ovarian, Primary Peritoneal, or Fallopian Cancer Before Surgery Recruiting